Cerebral Microdialysis in Traumatic Brain Injury and Subarachnoid Hemorrhage: State of the Art

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Citações na Scopus
49
Tipo de produção
article
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
HUMANA PRESS INC
Citação
NEUROCRITICAL CARE, v.21, n.1, p.152-162, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cerebral microdialysis (CMD) is a laboratory tool that provides on-line analysis of brain biochemistry via a thin, fenestrated, double-lumen dialysis catheter that is inserted into the interstitium of the brain. A solute is slowly infused into the catheter at a constant velocity. The fenestrated membranes at the tip of the catheter permit free diffusion of molecules between the brain interstitium and the perfusate, which is subsequently collected for laboratory analysis. The major molecules studied using this method are glucose, lactate, pyruvate, glutamate, and glycerol. The collected substances provide insight into the neurochemical features of secondary injury following traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) and valuable information about changes in brain metabolism within a short time frame. In this review, the authors detail the CMD technique and its associated markers and then describe pertinent findings from the literature about the clinical application of CMD in TBI and SAH.
Palavras-chave
Microdialysis, Metabolism, Brain injury, Monitoring, Subarachnoid hemorrhage, Critical care
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