Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: A cross-sectional study
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Citações na Scopus
25
Tipo de produção
article
Data de publicação
2014
Editora
ELSEVIER SCI LTD
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Autores
PEDROSO, Jose Luiz
FELICIO, Andre C.
BRAGA-NETO, Pedro
BATISTA, Ilza Rosa
BARSOTTINI, Orlando Graziani Povoas
BORGES, Vanderci
FERRAZ, Henrique Ballalai
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Citação
PARKINSONISM & RELATED DISORDERS, v.20, n.5, p.477-481, 2014
Resumo
Approximately 10% of patients with a presumed diagnosis of Parkinson's disease (PD) remain misdiagnosed despite recent advances in neuroimaging. The current study addresses the use of transcranial sonography and single-photon emission computed tomography (SPECT) using Tc-99m-TRODAT-1 to evaluate the echogenicity of the substantia nigra (SN) and the density of striatal presynaptic dopamine transporters, respectively, in a sample of 20 PD patients (13 males and 7 females) and 9 healthy subjects. The median age of the PD patients was 62 years. The median age at disease onset was 56 years, and the median disease duration was 5 years. The SN echogenic area was larger in PD patients than healthy subjects. The cut-off value of 0.22 cm(2) for the SN echogenic area was associated with 100% sensitivity and 78% specificity for the diagnosis of PD. Striatal and putaminal Tc-99m-TRODAT-1 binding was lower in PD patients than healthy subjects. The cut-off value of 0.90 for the striatal Tc-99m-TRODAT-1 binding was associated with 100% sensitivity and an 89% specificity for the diagnosis of PD, and the cut-off value of 0.76 for putaminal Tc-99m-TRODAT-1 binding was associated with an 85% sensitivity and an 89% specificity. The size of the SN echogenic area did not correlate with the degree of striatal Tc-99m-TRODAT-1 binding in PD patients. In conclusion, both SN hyperechogenicity and decreased striatal or putaminal Tc-99m-TRODAT-1 binding constitute surrogate markers for differentiating PD patients from healthy individuals with a slightly higher diagnostic specificity of Tc-99m-TRODAT-1 SPECT.
Palavras-chave
Parkinson's disease, Substantia nigra echogenicity, Transcranial sonography, SPELT, Dopamine transporter
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