Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis
Carregando...
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2014
Editora
NATURE PUBLISHING GROUP
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
CORREA-COSTA, Matheus
ANDRADE-OLIVEIRA, Vinicius
BRAGA, Tarcio T.
CASTOLDI, Angela
AGUIAR, Cristhiane F.
ORIGASSA, Clarice S. T.
RODAS, Andrea C. D.
HIYANE, Meire I.
RIOS, Francisco J. O.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
LABORATORY INVESTIGATION, v.94, n.4, p.455-466, 2014
Resumo
Platelet-activating factor (PAF) is a lipid mediator with important pro-inflammatory effects, being synthesized by several cell types including kidney cells. Although there is evidence of its involvement in acute renal dysfunction, its role in progressive kidney injury is not completely known. In the present study, we investigated the role of PAF receptor (PAFR) in an experimental model of chronic renal disease. Wild-type (WT) and PAFR knockout (KO) mice underwent unilateral ureter obstruction (UUO), and at kill time, urine and kidney tissue was collected. PAFR KO animals compared with WT mice present: (a) less renal dysfunction, evaluated by urine protein/creatinine ratio; (b) less fibrosis evaluated by collagen deposition, type I collagen, Lysyl Oxidase-1 (LOX-1) and transforming growth factor beta (TGF-beta) gene expression, and higher expression of bone morphogenetic protein 7 (BMP-7) (3.3-fold lower TGF-beta/BMP-7 ratio); (c) downregulation of extracellular matrix (ECM) and adhesion molecule-related machinery genes; and (d) lower levels of pro-inflammatory cytokines. These indicate that PAFR engagement by PAF or PAF-like molecules generated during UUO potentiates renal dysfunction and fibrosis and might promote epithelial-to-mesenchymal transition (EMT). Also, early blockade of PAFR after UUO leads to a protective effect, with less fibrosis deposition. In conclusion, PAFR signaling contributes to a pro-inflammatory environment in the model of obstructive nephropathy, favoring the fibrotic process, which lately will generate renal dysfunction and progressive organ failure.
Palavras-chave
chronic kidney disease, platelet activating factor receptor, renal fibrosis, renal inflammation
Referências
- Bascands JL, 2005, KIDNEY INT, V68, P925, DOI 10.1111/j.1523-1755.2005.00486.x
- Bataller R, 2005, J CLIN INVEST, V115, P209, DOI 10.1172/JCI200524282
- Bedi Surmeet, 2008, Transplant Rev (Orlando), V22, P1, DOI 10.1016/j.trre.2007.09.004
- Bennett SAL, 1998, CELL DEATH DIFFER, V5, P867, DOI 10.1038/sj.cdd.4400434
- Braga TT, 2012, MOL MED, V18, P1231, DOI 10.2119/molmed.2012.00131
- CAMUSSI G, 1984, KIDNEY INT, V25, P73, DOI 10.1038/ki.1984.10
- Castor MGM, 2012, J LEUKOCYTE BIOL, V91, P629, DOI 10.1189/jlb.1111561
- Chandrasekaran K, 2012, KIDNEY INT, V81, P617, DOI 10.1038/ki.2011.448
- Chen CH, 2003, CIRCULATION, V107, P2102, DOI 10.1161/01.CIR.0000065220.70220.F7
- Chen J, 1997, J PHARMACOL EXP THER, V280, P1219
- Chen ZG, 2003, CELL SIGNAL, V15, P843, DOI 10.1016/S0898-6568(03)00056-1
- Chung ACK, 2009, NEPHROL DIAL TRANSPL, V24, P1443, DOI 10.1093/ndt/gfn699
- Coresh J, 2007, JAMA-J AM MED ASSOC, V298, P2038, DOI 10.1001/jama.298.17.2038
- Correa-Costa M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014298
- Correa-Costa M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029004
- Cravedi P, 2012, NAT REV NEPHROL, V8, P301, DOI 10.1038/nrneph.2012.42
- de Lima AO, 2012, NEPHROL DIAL TRANSPL, V27, P135, DOI 10.1093/ndt/gfs063
- Doi K, 2006, AM J PATHOL, V168, P1413, DOI 10.2353/ajpath.2006.050634
- Dooley S, 2012, CELL TISSUE RES, V347, P245, DOI 10.1007/s00441-011-1246-y
- Duitman J, 2012, P NATL ACAD SCI USA, V109, P9113, DOI 10.1073/pnas.1202641109
- Fadok VA, 2001, J CLIN INVEST, V108, P957, DOI 10.1172/JCI14122
- Gonzalez-Ramos M, 2013, INT J BIOCHEM CELL B, V45, P232, DOI 10.1016/j.biocel.2012.10.001
- Gordon S, 2005, NAT REV IMMUNOL, V5, P953, DOI 10.1038/nri1733
- Hackett TL, 2012, CURR OPIN ALLERGY CL, V12, P53, DOI 10.1097/ACI.0b013e32834ec6eb
- Hasegawa S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010467
- Hwang M, 2006, EXP MOL PATHOL, V81, P48, DOI 10.1016/j.yexmp.2005.11.005
- Ishii S, 1998, J EXP MED, V187, P1779, DOI 10.1084/jem.187.11.1779
- Ishii S, 2000, PROG LIPID RES, V39, P41, DOI 10.1016/S0163-7827(99)00016-8
- Ishii S, 2002, PROSTAG OTH LIPID M, V68-9, P599, DOI 10.1016/S0090-6980(02)00058-8
- Karantonis HC, 2010, DIGEST DIS SCI, V55, P276, DOI 10.1007/s10620-009-0745-0
- Kovacic JC, 2012, CIRCULATION, V125, P1795, DOI 10.1161/CIRCULATIONAHA.111.040352
- Lacerda-Queiroz N, 2012, AM J PATHOL, V180, P246, DOI 10.1016/j.ajpath.2011.09.038
- Lee SB, 2010, KIDNEY INT, V78, pS22, DOI 10.1038/ki.2010.418
- Liu YH, 2011, NAT REV NEPHROL, V7, P684, DOI 10.1038/nrneph.2011.149
- Lopez-Novoa JM, 2009, EMBO MOL MED, V1, P303, DOI 10.1002/emmm.200900043
- Lopez-Novoa JM, 1999, KIDNEY INT, V55, P1672, DOI 10.1046/j.1523-1755.1999.00450.x
- Lu J, 2007, PEDIATR RES, V61, P427, DOI 10.1203/pdr.0b013e3180332ca5
- Mariano F, 1999, NEPHROL DIAL TRANSPL, V14, P1150, DOI 10.1093/ndt/14.5.1150
- Perico N, 1997, J AM SOC NEPHROL, V8, P1391
- Prunotto M, 2012, NEPHROL DIAL TRANSPL, V27, P43, DOI 10.1093/ndt/gfs283
- Prunotto M, 2012, J PATHOL
- Ribeiro S, 2012, HEMODIAL INT, V16, P481, DOI 10.1111/j.1542-4758.2012.00687.x
- Rios FJO, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036632
- Rios FJO, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076893
- Rios FJ, 2013, MEDIAT INFLAMM, V2013
- Rodrigues DH, 2012, BRAIN RES, V1385, P298
- Rodriguez C, 2008, DRUG NEWS PERSPECT, V21, P218, DOI 10.1358/dnp.2008.21.4.1213351
- Ruiz-Ortega M, 1998, NEPHROL DIAL TRANSPL, V13, P886, DOI 10.1093/ndt/13.4.886
- Ryan SD, 2007, J NEUROCHEM, V103, P88, DOI 10.1111/j.1471-4159.2007.04740.x
- SCHLONDORFF D, 1986, AM J PHYSIOL, V251, pF1
- Sharif NA, 2010, J OCUL PHARMACOL TH, V26, P21, DOI 10.1089/jop.2009.0102
- Sharma J, 2012, AM J PHYSIOL-LUNG C, V302, pL47, DOI 10.1152/ajplung.00179.2011
- Sharma SK, 2010, AM J KIDNEY DIS, V56, P915, DOI 10.1053/j.ajkd.2010.06.022
- Sipos F, 2012, WORLD J GASTROENTERO, V18, P601, DOI 10.3748/wjg.v18.i7.601
- STRUTZ F, 1995, J CELL BIOL, V130, P393, DOI 10.1083/jcb.130.2.393
- THAISS F, 1994, J LAB CLIN MED, V124, P775
- Torras J, 1999, KIDNEY INT, V56, P1798, DOI 10.1046/j.1523-1755.1999.00724.x
- Venkatesha RT, 2004, J BIOL CHEM, V279, P44606, DOI 10.1074/jbc.M408035200
- Wang S, 2003, KIDNEY INT, V63, P2037, DOI 10.1046/j.1523-1755.2003.00035.x
- Zeisberg M, 2004, J MOL MED-JMM, V82, P175, DOI 10.1007/s00109-003-0517-9
- Zeisberg M, 2003, NAT MED, V9, P964, DOI 10.1038/nm888
- Zeisberg M, 2003, AM J PHYSIOL-RENAL, V285, pF1060, DOI 10.1152/ajprenal.00191.2002
- Zeisberg M, 2005, J BIOL CHEM, V280, P8094, DOI 10.1074/jbc.M413102200
- Zimmerman GA, 2002, CRIT CARE MED, V30, pS294, DOI 10.1097/00003246-200205001-00020