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https://observatorio.fm.usp.br/handle/OPI/7792
Title: | CD226 rs763361 Is Associated with the Susceptibility to Type 1 Diabetes and Greater Frequency of GAD65 Autoantibody in a Brazilian Cohort |
Authors: | MATTANA, Teresa Cristina Colvara; SANTOS, Aritania Sousa; FUKUI, Rosa Tsuneshiro; MAINARDI-NOVO, Debora Teixeira Oliveira; COSTA, Vinicius Silva; SANTOS, Rosa Ferreira; MATIOLI, Sergio Russo; SILVA, Maria Elizabeth Rossi da |
Citation: | MEDIATORS OF INFLAMMATION, article ID 694948, 7p, 2014 |
Abstract: | CD226 rs763361 variant increases susceptibility to type 1 diabetes (T1D) in Caucasians. There is no data about CD226 variants in the very heterogeneous Brazilian population bearing a wide degree of admixture. We investigated its association with T1D susceptibility, clinical phenotypes, and autoimmune manifestations (islet and extrapancreatic autoantibodies). Casuistry. 532 T1D patients and 594 controls in a case-control study. Initially, CD226 coding regions and boundaries were sequenced in a subset of 106 T1D patients and 102 controls. In a second step, two CD226 variants, rs763361 (exon 7) and rs727088 (3' UTR region), involved with CD226 regulation, were genotyped in the entire cohort. C-peptide and autoantibody levels were determined. No new polymorphic variant was found. The variants rs763361 and rs727088 were in strong linkage disequilibrium. The TT genotype of rs763361 was associated with TID risk (OR = 1.503; 95% CI = 1.135-1.991; P = 0.0044), mainly in females ( P = 0.0012), greater frequency of anti-GAD autoantibody (31.9% x 24.5%; OR = 1.57; CI = 1.136-2.194; P = 0.0081), and lower C-peptide levels when compared to those with TC + CC genotypes (0.41 +/- 0.30 ng/dL versus 0.70 +/- 0.53 ng/dL P = 0.0218). Conclusions. The rs763361 variant of CD226 gene (TT genotype) was associated with susceptibility to T1D and with the degree of aggressiveness of the disease in T1D patients from Brazil. Ancestry had no effect. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/18 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_MATTANA_CD226_rs763361_Is_Associated_with_the_Susceptibility_to_2014.PDF | publishedVersion (English) | 1.26 MB | Adobe PDF | View/Open |
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