Distribution of HBV genotypes in Latin America

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ALVARADO-MORA, Monica V.
PINHO, Joao R. Rebello FMUSP-HC
dc.date.issued 2013
dc.identifier.citation ANTIVIRAL THERAPY, v.18, n.3, p.459-465, 2013
dc.identifier.issn 1359-6535
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/7861
dc.description.abstract Approximately 2 billion people worldwide are infected with HBV, and 350 million people are chronic carriers. HBV is classified into nine genotypes (A to I). Genotype F is the most prevalent in the Spanish-speaking countries and in the Amerindian population in South America. HBV genotype F was primarily found in indigenous populations from South America and is divided into four subgenotypes (F1 to F4). Subgenotype F1 is further divided into F1a (found in Costa Rica and El Salvador) and F1b (found in in Alaska, Argentina and Chile). Subgenotypes F2 and F3 cocirculate in the north of South America: F2a is found in Brazil and Venezuela, F2b is described only in Venezuela, F3 is frequent in Colombia, Venezuela and Panama, and F4 is reported from the central and south areas of South America, including Bolivia, Argentina and southern Brazil. HBV genotypes and subgenotypes have distinct geographical distributions. It is currently under discussion whether they are associated with different prognoses, considering the patterns of severity of liver diseases in various populations. Furthermore, global human migrations affect the pattern of genotype distribution, introducing genotypes differing from those found in the original inhabitants.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/50562-0, 2011/51597-1]
· CNPq
· Alves de Queiroz Family Fund
· Fundacao Faculdade de Medicina (FFM)
dc.language.iso eng
dc.relation.ispartof Antiviral Therapy
dc.rights restrictedAccess
dc.subject.other hepatitis-b-virus; molecular epidemiology; genetic diversity; phylogenetic analysis; evolutionary history; infected patients; subgenotype a1; core promoter; blood-donors; f prevails
dc.title Distribution of HBV genotypes in Latin America
dc.type article
dc.rights.holder Copyright INT MEDICAL PRESS LTD
dc.description.group LIM/07
dc.identifier.doi 10.3851/IMP2599
dc.identifier.pmid 23792558
dc.type.category review
dc.type.version publishedVersion
hcfmusp.author PINHO, Joao R. Rebello:HC:LIM/07
hcfmusp.author.external · ALVARADO-MORA, Monica V.:Univ Sao Paulo, Sch Med, Lab Trop Gastroenterol & Hepatol Joao Alves de Qu, Inst Trop Med,Dept Gastroenterol, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84879669138
hcfmusp.origem.id WOS:000335231500006
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 31
hcfmusp.citation.wos 31
hcfmusp.affiliation.country Brasil

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