BLOOD FLOW RESTRICTED RESISTANCE TRAINING ATTENUATES MYOSTATIN GENE EXPRESSION ON A PATIEINIT WITH ONCLUSION BODY MYOSITIS

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Arquivos
art_SANTOS_BLOOD_FLOW_RESTRICTED_RESISTANCE_TRAINING_ATTENUATES_MYOSTATIN_GENE_2014.PDF (239.98 KB)
Citações na Scopus
22
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INST SPORT
Autores
SANTOS, A. R.
NEVES JR., M. T.
LAURENTINO, G. C.
JR, A. H. Lancha
UGRINOWITSCH, C.
AOKI, M. S.
Citação
BIOLOGY OF SPORT, v.31, n.2, p.121-124, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Inclusion body myositis is a rare idiopathic inflammatory myopathy that produces extreme muscle weakness. Blood flow restricted resistance training has been shown to improve muscle strength and muscle hypertrophy in inclusion body myositis. Objective: The aim of this study was to evaluate the effects of a resistance training programme on the expression of genes related to myostatin (MSTN) signalling in one inclusion body myositis patient. Methods: A 65-year-old man with inclusion body myositis underwent blood flow restricted resistance training for 12 weeks. The gene expression of MSTN, follistatin, follistatin-like 3, activin II B receptor, SMAD-7, MyoD, FOXO-3, and MURF-2 was quantified. Results: After 12 weeks of training, a decrease (25%) in MSTN mRNA level was observed, whereas follistatin and follistatin-like 3 gene expression increased by 40% and 70%, respectively. SMAD-7 mRNA level was augmented (20%). FOXO-3 and MURF-2 gene expression increased by 40% and 20%, respectively. No change was observed in activin II B receptor or MyoD gene expression. Conclusions: Blood flow restricted resistance training attenuated MSTN gene expression and also increased expression of myostatin endogenous inhibitors. Blood flow restricted resistance training evoked changes in the expression of genes related to MSTN signalling pathway that could in part explain the muscle hypertrophy previously observed in a patient with inclusion body myositis.
Palavras-chave
GDF-8, muscle hypertrophy, mRNA, real-time PCR
URI
https://observatorio.fm.usp.br/handle/OPI/7887
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/17