Autophagy and female genital tract infections: new insights and research directions

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art_JAYARAM_Autophagy_and_female_genital_tract_infections_new_insights_2014.PDF (130.96 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
JAYARAM, A.
ORFANELLI, T.
DOULAVERIS, G.
LEDGER, W. J.
WITKIN, S. S.
Citação
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v.121, n.7, p.801-808, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Autophagy is a highly conserved process by which defective organelles, non-functional proteins, and intracellular microorganisms become sequestered within structures called autophagosomes, which fuse with lysosomes and the engulfed components are degraded by lysosomal enzymes. In microbial autophagy degraded peptides are used to induce antigen-specific acquired immunity. Viruses, bacteria, fungi, and protozoa have developed strategies to subvert autophagy and/or to use this process to promote their replication and persistence. This review details the mechanisms by which microorganisms that infect the female genital tract and/or are detrimental to pregnancy interact with this host defence mechanism. Based on an understanding of autophagy-related pathological mechanisms, we propose new avenues for research to more effectively prevent and/or treat these infectious diseases.
Palavras-chave
Autophagy, genital tract infections, pregnancy
URI
https://observatorio.fm.usp.br/handle/OPI/7965
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - HC/ICHC