Experimental model of Achilles tendon injury in rats

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author AKAMATSU, Flavia Emi FMUSP-HC
SALEH, Samir Omar FMUSP-HC
TEODORO, Walcy Rosolia FMUSP-HC
SILVA, Alexandre Queiroz da FMUSP-HC
MARTINEZ, Carlos Augusto Real
DUARTE, Ricardo Jordao FMUSP-HC
ANDRADE, Mauro Figueiredo Carvalho de FMUSP-HC
JACOMO, Alfredo Luiz FMUSP-HC
dc.date.issued 2014
dc.identifier.citation ACTA CIRURGICA BRASILEIRA, v.29, n.7, p.417-422, 2014
dc.identifier.issn 0102-8650
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/8257
dc.description.abstract PURPOSE: To describe an effective experimental model to study the Achilles tendon healing. METHODS: Forty male Rattus norvegicus albinus, Wistar lineage adult male weighing 250 to 300g were used for this experiment and thirty were surgically submitted to bilateral partial transverse section of the Achilles tendon. The right tendon was treated with radio waves (RF) whereas the left tendon served as control. On the third postoperative day, the rats were divided into four experimental groups consisting of ten rats each which were treated with monopolar RF adjusted to 650 kHz and 2w, for two minutes twice a week and a group of normal animals without any intervention, until they were sacrificed on the 7th, 14th and 28th days, respectively. Tendons were weighed and collagen quantification was evaluated by hydroxyprolin content. RESULTS: Significant reduction in collagen content on day 7, 14 and 28 was related to control experiment to normal tendon ( 7 days, p<0.01; 14 e 28 days, p<0.05). CONCLUSION: The experimental model has been effective and available to be used to study Achilles tendon healing.
dc.language.iso eng
dc.publisher ACTA CIRURGICA BRASILEIRA
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights openAccess
dc.subject Models, Animal; Achilles Tendon; Collagen Type I; Hydroxyproline; Radio Waves; Rats
dc.subject.other calcaneal tendon; collagen-fibers; repair; rabbit; ultrasound; rupture; tissue
dc.title Experimental model of Achilles tendon injury in rats
dc.type article
dc.rights.holder Copyright ACTA CIRURGICA BRASILEIRA
dc.description.group LIM/55
dc.description.group LIM/02
dc.description.group LIM/17
dc.identifier.doi 10.1590/S0102-86502014000700002
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author AKAMATSU, Flavia Emi:FM:MCG
hcfmusp.author SALEH, Samir Omar:FM:
hcfmusp.author TEODORO, Walcy Rosolia:FM:MCM
hcfmusp.author SILVA, Alexandre Queiroz da:HC:ICHC
hcfmusp.author DUARTE, Ricardo Jordao:HC:LIM/55
hcfmusp.author ANDRADE, Mauro Figueiredo Carvalho de:FM:MCG
hcfmusp.author JACOMO, Alfredo Luiz:FM:MCG
hcfmusp.author.external · MARTINEZ, Carlos Augusto Real:Univ Sao Francisco, Sch Med, Postgrad Program Hlth Sci, BR-12916350 Braganca Paulista, SP, Brazil
hcfmusp.origem.id WOS:000340835400002
hcfmusp.origem.id 2-s2.0-84904561030
hcfmusp.origem.id SCIELO:S0102-86502014000700417
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
dc.identifier.eissn 1678-2674
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 2
hcfmusp.affiliation.country Brasil


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