Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author WOJITANI, Maria Dulce Kaoro Horie FMUSP-HC
AGUIAR, Lana Maria de FMUSP-HC
BARACAT, Edmond Chada FMUSP-HC
LINHARES, Iara Moreno FMUSP-HC
dc.date.issued 2012
dc.identifier.citation ARCHIVES OF GYNECOLOGY AND OBSTETRICS, v.285, n.1, p.149-153, 2012
dc.identifier.issn 0932-0067
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/831
dc.description.abstract Objective The influence of functional polymorphisms in the genes coding for mannose-binding lectin (MBL) and interleukin-1 receptor antagonist (IL-1ra) on recurrent vulvovaginal candidiasis (RVVC) were examined in an urban Brazilian population. Methods DNA was isolated from buccal swabs of 100 women with RVVC and 100 control women and tested by gene amplification for a single nucleotide polymorphism in codon 54 of the MBL2 gene and for a length polymorphism in intron 2 of the IL1RN gene. Genotype and allele frequencies were compared between groups. Results The frequency of the variant MBL2 B allele, associated with reduced circulating and vaginal MBL concentrations, was 27.0% in RVVC and 8.5% in control women (p < .0001). The MBL2 B, B genotype was present in 12% of RVVC patients and 1% of controls (p = .0025). The IL1RN 2 allele frequency, associated with the highest level of unopposed IL-1 beta activity, was 24.0% in RVVC and 23.4% in controls. The IL1RN genotype distribution was also similar in both groups. Conclusion Carriage of the MBL2 codon 54 polymorphism, but not the IL1RN length polymorphism, predisposes to RVVC in Brazilian women.
dc.language.iso eng
dc.publisher SPRINGER HEIDELBERG
dc.relation.ispartof Archives of Gynecology and Obstetrics
dc.rights restrictedAccess
dc.subject Recurrent vulvovaginal candidiasis; Mannose-binding lectin; Interleukin-1 receptor antagonist; Genetic polymorphism
dc.subject.other host-defense; women; susceptibility; albicans; history
dc.title Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis
dc.type article
dc.rights.holder Copyright SPRINGER HEIDELBERG
dc.description.group LIM/58
dc.identifier.doi 10.1007/s00404-011-1920-z
dc.identifier.pmid 21655939
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author WOJITANI, Maria Dulce Kaoro Horie:HC:ICHC
hcfmusp.author AGUIAR, Lana Maria de:HC:ICHC
hcfmusp.author BARACAT, Edmond Chada:FM:MOG
hcfmusp.author LINHARES, Iara Moreno:HC:ICHC
hcfmusp.origem.id 2-s2.0-84860821438
hcfmusp.origem.id WOS:000299121900025
hcfmusp.publisher.city HEIDELBERG
hcfmusp.publisher.country GERMANY
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dc.description.index MEDLINE
hcfmusp.citation.scopus 17
hcfmusp.citation.wos 11


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