Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/8354
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | HEGELE, Robert A. | - |
dc.contributor.author | GINSBERG, Henry N. | - |
dc.contributor.author | CHAPMAN, M. John | - |
dc.contributor.author | NORDESTGAARD, Borge G. | - |
dc.contributor.author | KUIVENHOVEN, Jan Albert | - |
dc.contributor.author | AVERNA, Maurizio | - |
dc.contributor.author | BOREN, Jan | - |
dc.contributor.author | BRUCKERT, Eric | - |
dc.contributor.author | CATAPANO, Alberico L. | - |
dc.contributor.author | DESCAMPS, Olivier S. | - |
dc.contributor.author | HOVINGH, G. Kees | - |
dc.contributor.author | HUMPHRIES, Steve E. | - |
dc.contributor.author | KOVANEN, Petri T. | - |
dc.contributor.author | MASANA, Luis | - |
dc.contributor.author | PAJUKANTA, Paivi | - |
dc.contributor.author | PARHOFER, Klaus G. | - |
dc.contributor.author | RAAL, Frederick J. | - |
dc.contributor.author | RAY, Kausik K. | - |
dc.contributor.author | SANTOS, Raul D. | - |
dc.contributor.author | STALENHOEF, Anton F. H. | - |
dc.contributor.author | STROES, Erik | - |
dc.contributor.author | TASKINEN, Marja-Riitta | - |
dc.contributor.author | TYBJRG-HANSEN, Anne | - |
dc.contributor.author | WATTS, Gerald F. | - |
dc.contributor.author | WIKLUND, Olov | - |
dc.date.accessioned | 2015-02-06T19:10:50Z | - |
dc.date.available | 2015-02-06T19:10:50Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | LANCET DIABETES & ENDOCRINOLOGY, v.2, n.8, p.655-666, 2014 | - |
dc.identifier.issn | 2213-8587 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/8354 | - |
dc.description.abstract | Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of common and rare variants in more than 30 genes, as quantified by genetic risk scores. Rare autosomal recessive monogenic hypertriglyceridaemia can result from large-effect mutations in six different genes. Hypertriglyceridaemia is exacerbated by non-genetic factors. On the basis of recent genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/L), which is more likely to have a monogenic cause; and mild-to-moderate (triglyceride concentration 2-10 mmol/L). Because of clustering of susceptibility alleles and secondary factors in families, biochemical screening and counselling for family members is essential, but routine genetic testing is not warranted. Treatment includes management of lifestyle and secondary factors, and pharmacotherapy. In severe hypertriglyceridaemia, intervention is indicated because of pancreatitis risk; in mild-to-moderate hypertriglyceridaemia, intervention can be indicated to prevent cardiovascular disease, dependent on triglyceride concentration, concomitant lipoprotein disturbances, and overall cardiovascular risk. | - |
dc.description.sponsorship | Amgen | - |
dc.description.sponsorship | Aegerion | - |
dc.description.sponsorship | AstraZeneca | - |
dc.description.sponsorship | Genzyme | - |
dc.description.sponsorship | Hoff man-La Roche | - |
dc.description.sponsorship | Kowa Europe | - |
dc.description.sponsorship | Novartis | - |
dc.description.sponsorship | Sanofi-Aventis/Regeneron | - |
dc.description.sponsorship | Jacob J Wolfe Distinguished Medical Research Chair at the Western University | - |
dc.description.sponsorship | Edith Schulich Vinet Canada Research Chair in Human Genetics (Tier I) | - |
dc.description.sponsorship | Martha G Blackburn Chair in Cardiovascular Research | - |
dc.description.sponsorship | CIHR [MOP-13430, MOP79523, CTP-79853] | - |
dc.description.sponsorship | Heart and Stroke Foundation of Ontario [NA-6059, T-6018, PRG-4854] | - |
dc.description.sponsorship | European Atherosclerosis Society Consensus Panel Administration Office, London, UK | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.ispartof | Lancet Diabetes & Endocrinology | - |
dc.rights | restrictedAccess | - |
dc.subject.other | density-lipoprotein cholesterol | - |
dc.subject.other | ischemic-heart-disease | - |
dc.subject.other | homozygous familial hypercholesterolemia | - |
dc.subject.other | genome-wide association | - |
dc.subject.other | nonfasting triglycerides | - |
dc.subject.other | cardiovascular-disease | - |
dc.subject.other | plasma triglycerides | - |
dc.subject.other | remnant cholesterol | - |
dc.subject.other | general-population | - |
dc.subject.other | lipase deficiency | - |
dc.title | The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management | - |
dc.type | article | - |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | - |
dc.contributor.groupauthor | European Atherosclerosis Soc Conse | - |
dc.identifier.doi | 10.1016/S2213-8587(13)70191-8 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | HEGELE, Robert A.:Univ Western Ontario, Dept Med, London, ON, Canada | - |
hcfmusp.author.external | GINSBERG, Henry N.:Columbia Univ, Irving Inst Clin & Translat Res, New York, NY USA | - |
hcfmusp.author.external | CHAPMAN, M. John:Pitie Salpetriere Univ Hosp, Dyslipidaemia & Atherosclerosis Res Unit, INSERM U939, Paris, France | - |
hcfmusp.author.external | NORDESTGAARD, Borge G.:Univ Copenhagen, Dept Diagnost Sci, DK-1168 Copenhagen, Denmark | - |
hcfmusp.author.external | KUIVENHOVEN, Jan Albert:Univ Groningen, Univ Med Ctr Groningen, Dept Mol Genet, NL-9700 AB Groningen, Netherlands | - |
hcfmusp.author.external | AVERNA, Maurizio:Univ Palermo, Dept Internal Med, Palermo, Italy | - |
hcfmusp.author.external | BOREN, Jan:Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Strateg Res Ctr, Gothenburg, Sweden | - |
hcfmusp.author.external | BRUCKERT, Eric:Hop La Pitie Salpetriere, Dept Endocrinol & Metab Endocrinol & Cardiovasc, Paris, France | - |
hcfmusp.author.external | CATAPANO, Alberico L.:Univ Milan & Multimed IRCSS, Dept Pharmacol Sci, Milan, Italy | - |
hcfmusp.author.external | DESCAMPS, Olivier S.:Hop Jolimont, Lipid Clin, Ctr Rech Med, Haine Saint Paul, Belgium | - |
hcfmusp.author.external | HOVINGH, G. Kees:Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands | - |
hcfmusp.author.external | HUMPHRIES, Steve E.:UCL, Ctr Cardiovasc Genet, Inst Cardiovasc Sci, London, England | - |
hcfmusp.author.external | KOVANEN, Petri T.:Wihuri Res Inst, SF-00140 Helsinki, Finland | - |
hcfmusp.author.external | MASANA, Luis:Univ Rovira & Virgili, Sant Joan Univ Hosp, Vasc Med & Metab Unit, IISPV,CIBERDEM, E-43201 Reus, Spain | - |
hcfmusp.author.external | PAJUKANTA, Paivi:Univ Calif Los Angeles, David Geff Sch Med, Dept Human Genet, Los Angeles, CA USA | - |
hcfmusp.author.external | PARHOFER, Klaus G.:Univ Munich, Dept Endocrinol & Metab, Munich, Germany; Univ Witwatersrand, Div Endocrinol & Metab, Johannesburg, South Africa; Univ Witwatersrand, Lipid Metab Res Unit, Johannesburg, South Africa | - |
hcfmusp.author.external | RAY, Kausik K.:St Georges Hosp NHS Trust, Cardiovasc Sci Res Ctr, London, England | - |
hcfmusp.author.external | STALENHOEF, Anton F. H.:Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands | - |
hcfmusp.author.external | STROES, Erik:Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands | - |
hcfmusp.author.external | TASKINEN, Marja-Riitta:Univ Helsinki, Cent Hosp, Heart & Lung Ctr, Cardiovasc Res Grp, Helsinki, Finland; Univ Helsinki, Res Programs Unit, Helsinki, Finland | - |
hcfmusp.author.external | TYBJRG-HANSEN, Anne:Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark | - |
hcfmusp.author.external | WATTS, Gerald F.:Univ Western Australia, Royal Perth Hosp Unit, Sch Med & Pharmacol, Perth, WA 6009, Australia | - |
hcfmusp.author.external | WIKLUND, Olov:Sahlgrens Univ Hosp, Wallenberg Lab, Dept Cardiol, Gothenburg, Sweden | - |
hcfmusp.description.beginpage | 655 | - |
hcfmusp.description.endpage | 666 | - |
hcfmusp.description.issue | 8 | - |
hcfmusp.description.volume | 2 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84906937463 | - |
hcfmusp.origem.id | WOS:000341799900025 | - |
hcfmusp.publisher.city | NEW YORK | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Anderson TJ, 2013, CAN J CARDIOL, V29, P151, DOI 10.1016/j.cjca.2012.11.032 | - |
hcfmusp.relation.reference | Asselbergs FW, 2012, AM J HUM GENET, V91, P823, DOI 10.1016/j.ajhg.2012.08.032 | - |
hcfmusp.relation.reference | BABIRAK SP, 1989, ARTERIOSCLEROSIS, V9, P326 | - |
hcfmusp.relation.reference | Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309 | - |
hcfmusp.relation.reference | BEIL U, 1982, ARTERIOSCLEROSIS, V2, P44 | - |
hcfmusp.relation.reference | Berglund L, 2012, J CLIN ENDOCR METAB, V97, P2969, DOI 10.1210/jc.2011-3213 | - |
hcfmusp.relation.reference | Boekholdt SM, 2012, JAMA-J AM MED ASSOC, V307, P1302, DOI 10.1001/jama.2012.366 | - |
hcfmusp.relation.reference | Boullart ACI, 2012, BBA-MOL CELL BIOL L, V1821, P867, DOI 10.1016/j.bbalip.2011.10.002 | - |
hcfmusp.relation.reference | Catapano AL, 2011, ATHEROSCLEROSIS SUPP, V217, pS1 | - |
hcfmusp.relation.reference | Chapman MJ, 2011, EUR HEART J, V32, P1345, DOI 10.1093/eurheartj/ehr112 | - |
hcfmusp.relation.reference | Chen R, 2012, CELL, V148, P1293, DOI 10.1016/j.cell.2012.02.009 | - |
hcfmusp.relation.reference | Baigent C, 2005, LANCET, V366, P1267, DOI 10.1016/S0140-6736(05)67394-1 | - |
hcfmusp.relation.reference | Cuchel M, 2013, LANCET, V381, P40, DOI 10.1016/S0140-6736(12)61731-0 | - |
hcfmusp.relation.reference | Do R, 2013, NAT GENET, V45, P1345, DOI 10.1038/ng.2795 | - |
hcfmusp.relation.reference | Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486 | - |
hcfmusp.relation.reference | FREDRICK.DS, 1965, CIRCULATION, V31, P321 | - |
hcfmusp.relation.reference | Freiberg JJ, 2008, JAMA-J AM MED ASSOC, V300, P2142, DOI 10.1001/jama.2008.621 | - |
hcfmusp.relation.reference | Gaudet D, 2010, ATHEROSCLEROSIS SUPP, V11, P55, DOI 10.1016/j.atherosclerosissup.2010.03.004 | - |
hcfmusp.relation.reference | GOUSSAULT Y, 1982, CLIN CHIM ACTA, V123, P269, DOI 10.1016/0009-8981(82)90171-1 | - |
hcfmusp.relation.reference | Guerin M, 2002, J LIPID RES, V43, P1652, DOI 10.1194/jlr.M200135-JLR200 | - |
hcfmusp.relation.reference | Hawrylycz MJ, 2012, NATURE, V489, P391, DOI 10.1038/nature11405 | - |
hcfmusp.relation.reference | Hegele RA, 2009, HUM MOL GENET, V18, P4189, DOI 10.1093/hmg/ddp361 | - |
hcfmusp.relation.reference | HEGELE RA, 1991, ARTERIOSCLER THROMB, V11, P1303 | - |
hcfmusp.relation.reference | Hegele RA, 2009, NAT REV GENET, V10, P109, DOI 10.1038/nrg2481 | - |
hcfmusp.relation.reference | Huijgen R, 2010, CLIN THER, V32, P615, DOI 10.1016/j.clinthera.2010.04.014 | - |
hcfmusp.relation.reference | Johansen CT, 2012, BBA-MOL CELL BIOL L, V1821, P833, DOI 10.1016/j.bbalip.2011.10.007 | - |
hcfmusp.relation.reference | Johansen CT, 2011, CURR OPIN LIPIDOL, V22, P247, DOI 10.1097/MOL.0b013e3283471972 | - |
hcfmusp.relation.reference | Johansen CT, 2011, ARTERIOSCL THROM VAS, V31, P1916, DOI 10.1161/ATVBAHA.111.226365 | - |
hcfmusp.relation.reference | Johansen CT, 2012, CIRC-CARDIOVASC GENE, V5, P66, DOI 10.1161/CIRCGENETICS.111.960864 | - |
hcfmusp.relation.reference | Johansen CT, 2010, NAT GENET, V42, P684, DOI 10.1038/ng.628 | - |
hcfmusp.relation.reference | Johansen CT, 2011, J LIPID RES, V52, P189, DOI 10.1194/jlr.R009720 | - |
hcfmusp.relation.reference | Jorgensen AB, 2013, EUR HEART J, V34, P1826, DOI 10.1093/eurheartj/ehs431 | - |
hcfmusp.relation.reference | Jun M, 2010, LANCET, V375, P1875, DOI 10.1016/S0140-6736(10)60656-3 | - |
hcfmusp.relation.reference | Langsted A, 2011, CLIN CHEM, V57, P482, DOI 10.1373/clinchem.2010.157164 | - |
hcfmusp.relation.reference | Lee JH, 2011, NAT MED, V17, P812, DOI 10.1038/nm.2347 | - |
hcfmusp.relation.reference | Malloy M J, 2001, Adv Intern Med, V47, P111 | - |
hcfmusp.relation.reference | Mamo JCL, 1998, ATHEROSCLEROSIS, V141, pS63, DOI 10.1016/S0021-9150(98)00220-2 | - |
hcfmusp.relation.reference | Morrone D, 2012, ATHEROSCLEROSIS, V223, P251, DOI 10.1016/j.atherosclerosis.2012.02.016 | - |
hcfmusp.relation.reference | Musunuru K, 2010, NEW ENGL J MED, V363, P2220, DOI 10.1056/NEJMoa1002926 | - |
hcfmusp.relation.reference | Ng DS, 2013, NAT REV ENDOCRINOL, V9, P308, DOI 10.1038/nrendo.2012.238 | - |
hcfmusp.relation.reference | Norata GD, 2007, ATHEROSCLEROSIS, V193, P321, DOI 10.1016/j.atherosclerosis.2006.09.015 | - |
hcfmusp.relation.reference | NORDESTGAARD BG, 1995, ARTERIOSCL THROM VAS, V15, P534 | - |
hcfmusp.relation.reference | Nordestgaard BG, 2011, CURR VASC PHARMACOL, V9, P281 | - |
hcfmusp.relation.reference | Nordestgaard BG, 2009, CLIN CHEM, V55, P845, DOI 10.1373/clinchem.2008.123083 | - |
hcfmusp.relation.reference | Nordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299 | - |
hcfmusp.relation.reference | Nordestgaard BG, 1997, CIRCULATION, V96, P1737 | - |
hcfmusp.relation.reference | Oliva CP, 2005, ARTERIOSCL THROM VAS, V25, P411, DOI 10.1161/01.ATV.0000153087.36428.dd | - |
hcfmusp.relation.reference | Pollin TI, 2008, SCIENCE, V322, P1702, DOI 10.1126/science.1161524 | - |
hcfmusp.relation.reference | Raal FJ, 2010, LANCET, V375, P998, DOI 10.1016/S0140-6736(10)60284-X | - |
hcfmusp.relation.reference | Rahalkar AR, 2009, CAN J PHYSIOL PHARM, V87, P151, DOI [10.1139/y09-005, 10.1139/Y09-005] | - |
hcfmusp.relation.reference | Reiner Z, 2011, EUR HEART J, V32, P1769, DOI 10.1093/eurheartj/ehr158 | - |
hcfmusp.relation.reference | Rizos EC, 2012, JAMA-J AM MED ASSOC, V308, P1024, DOI 10.1001/2012.jama.11374 | - |
hcfmusp.relation.reference | Sacks FM, 2010, NEW ENGL J MED, V363, P692 | - |
hcfmusp.relation.reference | Sarwar N, 2010, LANCET, V375, P1634 | - |
hcfmusp.relation.reference | Sarwar N, 2009, CURR OPIN LIPIDOL, V20, P275, DOI 10.1097/MOL.0b013e32832dd4dc | - |
hcfmusp.relation.reference | Sarwar N, 2007, CIRCULATION, V115, P450, DOI 10.1161/CIRCULATIONAHA.106.637793 | - |
hcfmusp.relation.reference | Di Angelantonio E, 2009, JAMA-J AM MED ASSOC, V302, P1993 | - |
hcfmusp.relation.reference | Sniderman AD, 2011, CIRC-CARDIOVASC QUAL, V4, P337, DOI 10.1161/CIRCOUTCOMES.110.959247 | - |
hcfmusp.relation.reference | Soutar AK, 2007, NAT CLIN PRACT CARD, V4, P214, DOI 10.1038/ncpcardio0836 | - |
hcfmusp.relation.reference | Staels B, 1998, CIRCULATION, V98, P2088 | - |
hcfmusp.relation.reference | Stroes ES, 2008, ARTERIOSCL THROM VAS, V28, P2303, DOI 10.1161/ATVBAHA.108.175620 | - |
hcfmusp.relation.reference | Talmud PJ, 2013, LANCET, V381, P1293, DOI 10.1016/S0140-6736(12)62127-8 | - |
hcfmusp.relation.reference | Teslovich TM, 2010, NATURE, V466, P707, DOI 10.1038/nature09270 | - |
hcfmusp.relation.reference | Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579 | - |
hcfmusp.relation.reference | Varbo A, 2013, J AM COLL CARDIOL, V61, P427, DOI 10.1016/j.jacc.2012.08.1026 | - |
hcfmusp.relation.reference | Yuan G, 2007, CAN MED ASSOC J, V176, P1113, DOI 10.1503/cmaj.060963 | - |
hcfmusp.relation.reference | ZILVERSMIT DB, 1979, CIRCULATION, V60, P473 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 454 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_HEGELE_The_polygenic_nature_of_hypertriglyceridaemia_implications_for_definition_2014.PDF Restricted Access | publishedVersion (English) | 263.26 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.