Pre-treatment neutrophil-to-lymphocyte ratio affects survival in patients with advanced hepatocellular carcinoma treated with sorafenib
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41
Tipo de produção
article
Data de publicação
2014
Editora
HUMANA PRESS INC
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Citação
MEDICAL ONCOLOGY, v.31, n.11, article ID 264, 6p, 2014
Resumo
Sorafenib is the first systemic therapy to demonstrate survival benefit in advanced hepatocellular carcinoma (HCC) in randomized controlled trials with rigorous patient selection. Neutrophil-to-lymphocyte ratio (NLR) has been shown to be associated with poor survival in various solid tumors. Our aim is to evaluate the prognostic role of NLR in HCC patients treated with sorafenib. A total of 105 advanced HCC patients treated with sorafenib were retrospectively reviewed, and relevant data from the clinical records were collected. Univariate and multivariate analysis were carried out to identify factors associated with survival. The median age of the cohort was 59.7 years, and 84.8 % were Child-Pugh class A, and 86.7 % had ECOG performance status 0 or 1. Median duration of sorafenib treatment was 100 days. Median overall survival (OS) of the entire cohort was 8.03 months. Median OSwas 5.23 months (95 % CI 2.96-7.50 months) and 10.05 months (95 % IC 2.52-18.47 months) for patients with NLR>3.5 and NLR <= 3.5, respectively (p = 0.002). Alpha-fetoprotein [1,030 ng/mL and serum albumin B3.8 g/dL were also associated with worse prognosis (p = 0.006 and p = 0.042, respectively). The subgroup of patients with high alpha-fetoprotein, low albumin and NLR>3.5 had median OS of 1.7 months, whereas the subgroup with none of these parameters had median OS of 16.5 months (p< 0.001). NLR affects survival in advanced HCC patients treated with sorafenib. Selecting HCC patients based on the laboratorial features may improve the therapeutic effectiveness of sorafenib.
Palavras-chave
Hepatocellular cancer, Sorafenib tosylate, Neutrophil count, Lymphocyte count, Prognosis
Referências
- An X, 2010, BIOMARKERS, V15, P516, DOI 10.3109/1354750X.2010.491557
- Baek KK, 2011, ONCOLOGY-BASEL, V80, P167, DOI 10.1159/000327591
- Bruix J, 2011, HEPATOLOGY, V53, P1020, DOI 10.1002/hep.24199
- Cheng AL, 2009, LANCET ONCOL, V10, P25, DOI 10.1016/S1470-2045(08)70285-7
- Gomez D, 2008, WORLD J SURG, V32, P1757, DOI 10.1007/s00268-008-9552-6
- Hanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013
- Johnson P J, 2001, Clin Liver Dis, V5, P145, DOI 10.1016/S1089-3261(05)70158-6
- Kishi Y, 2009, ANN SURG ONCOL, V16, P614, DOI 10.1245/s10434-008-0267-6
- Kuang DM, 2011, J HEPATOL, V54, P948, DOI 10.1016/j.jhep.2010.08.041
- Limaye AR, 2013, HEPATOL RES, V43, P757, DOI 10.1111/hepr.12019
- Llovet JM, 2012, CLIN CANCER RES, V18, P2290, DOI 10.1158/1078-0432.CCR-11-2175
- Llovet JM, 2008, NEW ENGL J MED, V359, P378, DOI 10.1056/NEJMoa0708857
- Llovet Josep M, 2004, Liver Transpl, V10, pS115, DOI 10.1002/lt.20034
- Mantovani A, 2008, NATURE, V454, P436, DOI 10.1038/nature07205
- McNally ME, 2013, ANN SURG ONCOL, V20, P923, DOI 10.1245/s10434-012-2639-1
- Motomura T, 2013, J HEPATOL, V58, P58, DOI 10.1016/j.jhep.2012.08.017
- NOMURA F, 1989, CANCER, V64, P1700, DOI 10.1002/1097-0142(19891015)64:8<1700::AID-CNCR2820640824>3.0.CO;2-Z
- Ohtani H, 2007, CANC IMMUN, V21, P4
- Parkin DM, 2005, CA-CANCER J CLIN, V55, P74
- Templeton AJ, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju124
- Yamanaka T, 2007, ONCOLOGY-BASEL, V73, P215, DOI 10.1159/000127412
- Zhang Z, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-41
Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/61
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/61
Artigos e Materiais de Revistas Científicas - ODS/03