Brain regions supporting verbal memory improvement in healthy older subjects

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art_MIOTTO_Brain_regions_supporting_verbal_memory_improvement_in_healthy_2014.PDF (534.06 KB)
Citações na Scopus
13
Tipo de produção
article
Data de publicação
2014
Editora
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI
Indexadores
SciELO
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Autores
SAVAGE, Cary R.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
ARQUIVOS DE NEURO-PSIQUIATRIA, v.72, n.9, p.663-670, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Despite growing interest in developing cognitive training interventions to minimize the aging cognitive decline process, no studies have attempted to explore which brain regions support the application of semantic strategies during verbal memory encoding. Our aim was to investigate the behavioral performance and brain correlates of these strategies in elderly individuals using fMRI in healthy older subjects. Method: Subjects were scanned twice on the same day, before and after, directed instructions to apply semantic strategies during the encoding of word lists. Results: Improved memory performance associated to increased semantic strategy application and brain activity in the left inferior and middle and right medial superior prefrontal cortex were found after the directed instructions. There was also reduced activation in areas related to strategy mobilization. Conclusion: Improved memory performance in older subjects after the application of semantic strategies was associated with functional brain reorganization involving regions inside and outside the typical memory network.
Palavras-chave
older subjects, semantic strategies, fMRI, episodic memory
URI
https://observatorio.fm.usp.br/handle/OPI/8407
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/21
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