Therapeutic approaches for spinal cord injury

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CRISTANTE, Alexandre Fogaca FMUSP-HC
BARROS FILHO, Tarcisio Eloy Pessao de FMUSP-HC
MARCON, Raphael Martus FMUSP-HC
LETAIF, Olavo Biraghi FMUSP-HC
ROCHA, Ivan Dias da FMUSP-HC
dc.date.issued 2012
dc.identifier.citation CLINICS, v.67, n.10, p.1219-1224, 2012
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/849
dc.description.abstract This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a ""disease that should not be treated."" Over the last two decades, several studies have been performed to obtain more effective treatments for spinal cord injury. Most of these studies approach a patient with acute spinal cord injury in one of four manners: corrective surgery or a physical, biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life.
dc.language.iso eng
dc.publisher HOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject Spinal Cord Injuries; Rehabilitation; Central Nervous System/Injuries
dc.subject.other randomized controlled-trial; hyperbaric-oxygen therapy; mesenchymal stem-cells; wistar rats; neurological function; tirilazad mesylate; progenitor cells; methylprednisolone; recovery; exercise
dc.title Therapeutic approaches for spinal cord injury
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/41
dc.identifier.doi 10.6061/clinics/2012(10)16
dc.identifier.pmid 23070351
dc.type.category review
dc.type.version publishedVersion
hcfmusp.author CRISTANTE, Alexandre Fogaca:FM:MOT
hcfmusp.author BARROS FILHO, Tarcisio Eloy Pessao de:FM:MOT
hcfmusp.author MARCON, Raphael Martus:HC:IOT
hcfmusp.author LETAIF, Olavo Biraghi:HC:IOT
hcfmusp.author ROCHA, Ivan Dias da:FM:
hcfmusp.origem.id WOS:000309938100016
hcfmusp.origem.id 2-s2.0-84868299081
hcfmusp.origem.id SCIELO:S1807-59322012001000016
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 25
hcfmusp.citation.wos 25


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