Therapeutic approaches for spinal cord injury

Imagem de Miniatura
Arquivos
art_CRISTANTE_Therapeutic_approaches_for_spinal_cord_injury_2012.PDF (89.19 KB)
Citações na Scopus
63
Tipo de produção
article
Data de publicação
2012
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
DOI
Indexadores
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CLINICS, v.67, n.10, p.1219-1224, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a ""disease that should not be treated."" Over the last two decades, several studies have been performed to obtain more effective treatments for spinal cord injury. Most of these studies approach a patient with acute spinal cord injury in one of four manners: corrective surgery or a physical, biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life.
Palavras-chave
Spinal Cord Injuries, Rehabilitation, Central Nervous System/Injuries
URI
https://observatorio.fm.usp.br/handle/OPI/849
Referências
  1. ALBIN MS, 1987, CRIT CARE CLIN, V3, P441
  2. Allen AR, 1911, JAMA-J AM MED ASSOC, V57, P878
  3. Barros Filho TEP, 2006, ACTA ORTOP BRAS, V14, P75
  4. Barros Filho TEP, 2002, REV HOSP CLIN FAC ME, V57, P257
  5. Bjorklund A, 2000, NAT NEUROSCI, V3, P537, DOI 10.1038/75705
  6. BLIGHT AR, 1983, NEUROSCIENCE, V10, P521, DOI 10.1016/0306-4522(83)90150-1
  7. Blight A R, 2001, Curr Opin Investig Drugs, V2, P801
  8. Botelho RV, 2009, REV ASSOC MED BRAS, V55, P729
  9. Bouhy D, 2011, J NEUROSCI, V31, P16298, DOI 10.1523/JNEUROSCI.0047-11.2011
  10. Bracken MB, 1997, JAMA-J AM MED ASSOC, V277, P1597, DOI 10.1001/jama.277.20.1597
  11. Bracken MB, 1998, J NEUROSURG, V89, P699, DOI 10.3171/jns.1998.89.5.0699
  12. BRACKEN MB, 1993, J NEUROSURG, V79, P500, DOI 10.3171/jns.1993.79.4.0500
  13. BRACKEN MB, 1985, J NEUROSURG, V63, P704, DOI 10.3171/jns.1985.63.5.0704
  14. BRACKEN MB, 1992, J NEUROSURG, V76, P23, DOI 10.3171/jns.1992.76.1.0023
  15. Brackett NL, 2007, J SPINAL CORD MED, V30, P272
  16. Brazelton TR, 2000, SCIENCE, V290, P1775, DOI 10.1126/science.290.5497.1775
  17. Breasted JH, 1930, E SMITH SURG PAPYRUS
  18. Bregman BS, 1994, NEURAL TRANSPLANTATI, P81
  19. BUNGE RP, 1993, ADV NEUROL, V59, P75
  20. Cizkova D, 2006, CELL MOL NEUROBIOL, V26, P1167, DOI 10.1007/s10571-006-9093-1
  21. Cristante AF, 2012, SPINAL CORD, V50, P502, DOI 10.1038/sc.2012.16
  22. Cristante AF, 2009, SPINAL CORD, V47, P458, DOI 10.1038/sc.2008.155
  23. Cristante AF, 2010, ACTA ORTOP BRAS, V18, P284
  24. Cristante AF, 2012, NEUROSURGERY, V70, P835, DOI 10.1227/NEU.0b013e3182367417
  25. Cristante AF, 2009, SPINAL CORD, V47, P733, DOI 10.1038/sc.2009.24
  26. Cristante AF, 2011, REV BRAS ORTOP, V46, P359
  27. Cristante AF, 2012, NEUROSURGERY, V70, P838
  28. Damasceno ML, 2010, COLUNA, V9, P376, DOI 10.1590/S1808-18512010000400006
  29. Domingo A, 2012, J NEUROTRAUM, V29, P865, DOI 10.1089/neu.2011.2052
  30. Fehlings MG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032037
  31. Ferreira AFB, 2010, BRAIN RES, V1361, P31, DOI 10.1016/j.brainres.2010.09.045
  32. Foret A, 2010, J NEUROCHEM, V112, P762, DOI 10.1111/j.1471-4159.2009.06500.x
  33. Fouad K, 2011, BRAIN RES BULL, V84, P337, DOI 10.1016/j.brainresbull.2010.04.017
  34. GAGE FH, 1995, P NATL ACAD SCI USA, V92, P11879, DOI 10.1073/pnas.92.25.11879
  35. Galvao PED, 2011, ACTA ORTOP BRAS, V19, P10
  36. Gebrin AS, 1997, ACTA ORTOP BRAS, V5, P123
  37. Gerin CG, 2010, SYNAPSE, V64, P855, DOI 10.1002/syn.20802
  38. Grijalva I, 2010, ARCH MED RES, V41, P567, DOI 10.1016/j.arcmed.2010.10.001
  39. Guimaraes PEM, 2009, SPINAL CORD, V47, P171, DOI 10.1038/sc.2008.67
  40. Hall ED, 2011, NEUROTHERAPEUTICS, V8, P152, DOI 10.1007/s13311-011-0026-4
  41. Hall Edward D, 2004, NeuroRx, V1, P80, DOI 10.1007/BF03206569
  42. Hawryluk GWJ, 2008, NEUROSURG FOCUS, V25, DOI 10.3171/FOC.2008.25.11.E14
  43. Iutaka AS, 2006, ACTA ORTOP BRAS, V14, P261
  44. JANSSEN L, 1989, SPINE, V14, P23, DOI 10.1097/00007632-198901000-00005
  45. Jia Z, 2012, SPINAL CORD, V50, P264, DOI 10.1038/sc.2011.111
  46. Kajimoto BHJ, 2007, ACTA ORTOP BRAS, V15, P84
  47. Kakulas B A, 1984, Cent Nerv Syst Trauma, V1, P117
  48. Kao T, 2006, BRAIN RES, V1112, P159, DOI 10.1016/j.brainres.2006.07.020
  49. KELLY DL, 1972, J NEUROSURG, V36, P425, DOI 10.3171/jns.1972.36.4.0425
  50. Letaif OB, 2010, COLUNA, V9, P358, DOI 10.1590/S1808-18512010000400003
  51. Marcon RM, 2010, ACTA ORTOP BRAS, V18, P26
  52. McDonald JW, 2002, PROG BRAIN RES, V137, P299
  53. Narazaki Douglas Kenji, 2006, Clinics (Sao Paulo), V61, P453
  54. Nehrt A, 2007, NEUROSCIENCE, V146, P1504, DOI 10.1016/j.neuroscience.2007.02.015
  55. Netto CD, 2010, ACTA ORTOP BRAS, V18, P315
  56. Pittenger MF, 2000, CURR TOP MICROBIOL, V251, P3
  57. POTTEN CS, 1990, DEVELOPMENT, V110, P1001
  58. Rodrigues NR, 2010, ACTA ORTOP BRAS, V18, P182
  59. Santos GB, 2011, ACTA ORTOP BRAS, V19, P87
  60. Schwab ME, 1996, PHYSIOL REV, V76, P319
  61. Shi RY, 2011, NEUROSCI BULL, V27, P36, DOI 10.1007/s12264-011-1048-y
  62. Ung RV, 2008, EUR J NEUROSCI, V28, P2231, DOI 10.1111/j.1460-9568.2008.06508.x
  63. Vaccaro AR, 1997, SPINE, V22, P2609, DOI 10.1097/00007632-199711150-00006
  64. van Middendorp JJ, 2012, SPINAL CORD, V17
  65. Winter B, 2007, NEUROBIOL LEARN MEM, V87, P597, DOI 10.1016/j.nlm.2006.11.003
  66. YEO JD, 1976, MED J AUSTRALIA, V1, P538
  67. Ying Z, 2008, NEUROSCIENCE, V155, P1070, DOI 10.1016/j.neuroscience.2008.06.057

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOT
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/41