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https://observatorio.fm.usp.br/handle/OPI/8523
Title: | Foxp3 expression in deep rectosigmoid endometriosis lesions and its association with chronic pelvic pain |
Authors: | PODGAEC, Sergio; BARBEIRO, Denise Frediani; GUEUVOGHLANIAN-SILVA, Barbara Yasmin; BELLELIS, Patrick; ABRAO, Mauricio Simoes; BARACAT, Edmund Chada |
Citation: | JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.104, Special Issue, p.96-99, 2014 |
Abstract: | Endometriosis is a benign gynecological disease that is related to immune response alterations. T regulatory cells modulate immune response, and Foxp3 seems to be the best marker of these cells. This study evaluated Foxp3 mRNA expression in eutopic endometrium from women with endometriosis and healthy controls, and its expression in deep rectosigmoid endometriosis lesions, one of the more aggressive types of the disease. Foxp3 expression was higher in lesions than in eutopic endometrium in the two groups. Moreover, eutopic endometrium Foxp3 expression of women with endometriosis was associated with chronic pelvic pain and cyclic urinary pain. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - LIM/58 |
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