Reversal of metabolic adaptations induced by physical training after two weeks of physical detraining

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art_MAZZUCATTO_Reversal_of_metabolic_adaptations_induced_by_physical_training_2014.PDF (483.05 KB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2014
Editora
E-CENTURY PUBLISHING CORP
Indexadores
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Autores
MAZZUCATTO, Flavio
HIGA, Talita S.
EVANGELISTA, Fabiana S.
Autor de Grupo de pesquisa
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Organizadores
Citação
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, v.7, n.8, p.2000-2008, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The present study aimed to evaluate the effect of two weeks of physical detraining (PD) on energy balance components, white adipose tissue (WAT) metabolism, body weight (BW) and adiposity. Male C57BL/6J mice were assigned into groups sedentary (S, n = 20) and trained (T, n = 18). Physical training (PT) consisted of two 1.5 h daily sessions of swimming, 5 times/week for 4 weeks. After the PT, some of the S (S4, n = 10) and T (T4, n = 8) animals were sacrificed, and the others were kept sedentary (S6, n = 10) or detrained for two weeks (D, n = 10). After PT, the T group showed lower BW compared with S group, but PD reversed this response. The BW gains were 4%, 3% and 6.3% in S, S6 and D groups, respectively, however the T group decreased by 1.7%. T4 and D groups showed lower visceral fat depots and larger heart and left ventricle weights compared with S4 and S6 groups. Food intake, oxygen consumption at rest and fasting-induced weight loss were higher in T4 group compared with S4, and this was reversed by PD. Serum concentration of insulin, the activity of enzyme FAS and mean blood pressure did not differ among groups, but the concentration of leptin and resting heart rate were lower in T4 and D groups compared with S4 and S6 groups. T4 group increased lipolytic activity stimulated by isoproterenol and citrate synthase activity, which were reversed by PD. In conclusion, PD reversed the components of energy balance by reducing food intake and resting metabolism, and impaired WAT lipolytic activity, but not lipogenic activity. These changes resulted in remodeling of BW, but not adiposity.
Palavras-chave
Physical training suspension, energy balance, body weight, lipolysis
URI
https://observatorio.fm.usp.br/handle/OPI/8779
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/13