Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks

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art_SATO_Cerebrospinal_Fluid_Aquaporin4_Antibody_Levels_in_Neuromyelitis_Optica_2014.PDF (143.78 KB)
Citações na Scopus
47
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
SATO, Douglas Kazutoshi
NAKASHIMA, Ichiro
NISHIYAMA, Shuhei
TAKAHASHI, Toshiyuki
MISU, Tatsuro
STEINMAN, Lawrence
Citação
ANNALS OF NEUROLOGY, v.76, n.2, p.305-309, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.
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URI
https://observatorio.fm.usp.br/handle/OPI/8841
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Coleções
Artigos e Materiais de Revistas Científicas - HC/Outros
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/45