Association between psoriasis and coronary calcium score

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author STANIAK, Henrique L. FMUSP-HC
BITTENCOURT, Marcio Sommer FMUSP-HC
SANTOS, Itamar de Souza FMUSP-HC
SHAROVSKY, Rodolfo
SABBAG, Cid FMUSP-HC
GOULART, Alessandra C. FMUSP-HC
LOTUFO, Paulo A. FMUSP-HC
BENSENOR, Isabela M. FMUSP-HC
dc.date.issued 2014
dc.identifier.citation ATHEROSCLEROSIS, v.237, n.2, p.847-852, 2014
dc.identifier.issn 0021-9150
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/8916
dc.description.abstract Background: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). Objective: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). Methods: We investigated 221 participants with psoriasis and 718 age-and sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam. Logistic regression models adjusted for Framingham risk score (FRS) and C-reactive protein (hs-CRP) were built. CAC was included in the models as a binary variable with different cut off values. Results: Body-mass index, race, hypertension, HDL, LDL and hs-CRP were significantly associated with psoriasis presence and severity. Psoriasis severity was significantly associated with CAC (p = 0.04), particularly for very high CAC (>400) (p <0.01). The OR for severe psoriasis and CAC >400 was 2.45 (95%CI: 1.26-4.75) in unadjusted models. In a model adjusted for the FRS, this association was no longer significant, but a trend was noted (p = 0.09). No significant changes in the association were noted after the inclusion of hs-CRP in the model. Conclusion: Psoriasis is associated with higher CAC values, mainly in individuals with severe psoriasis. The current findings also suggest the potential involvement of other mechanisms beyond classical cardiovascular risk factors and inflammation in this association.
dc.description.sponsorship · CNPq
· Fundacao para Amparo a Pesquisa do Estado de Sao Paulo, Sao Paulo, Brazil [2011/7601-4, 2011/12256-4]
· Brazilian Ministry of Health (Science and Technology Department), Brasilia, Brazil [FINEP: 06 0115.00 SP]
dc.language.iso eng
dc.publisher ELSEVIER IRELAND LTD
dc.relation.ispartof Atherosclerosis
dc.rights restrictedAccess
dc.subject Coronary artery calcium; Cardiovascular disease; Cardiovascular risk factors; Psoriasis; Subclinical atherosclerosis
dc.subject.other subclinical atherosclerosis; artery-disease; risk-factors; arthritis; prevalence; health
dc.title Association between psoriasis and coronary calcium score
dc.type article
dc.rights.holder Copyright ELSEVIER IRELAND LTD
dc.description.group LIM/51
dc.identifier.doi 10.1016/j.atherosclerosis.2014.11.004
dc.identifier.pmid 25463132
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author STANIAK, Henrique L.:HU:DVCLME-62
hcfmusp.author BITTENCOURT, Marcio Sommer:FM:
hcfmusp.author SANTOS, Itamar de Souza:FM:MCM
hcfmusp.author SABBAG, Cid:FM:
hcfmusp.author GOULART, Alessandra C.:HC:LIM/51
hcfmusp.author LOTUFO, Paulo A.:FM:MCM
hcfmusp.author BENSENOR, Isabela M.:FM:MCM
hcfmusp.author.external · SHAROVSKY, Rodolfo:Univ Sao Paulo, Univ Hosp, Div Internal Med, BR-05508 Sao Paulo, Brazil; Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, BR-05508 Sao Paulo, Brazil
hcfmusp.origem.id WOS:000346066600101
hcfmusp.origem.id 2-s2.0-84911123142
hcfmusp.publisher.city CLARE
hcfmusp.publisher.country IRELAND
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dc.description.index MEDLINE
dc.identifier.eissn 1879-1484
hcfmusp.citation.scopus 13
hcfmusp.citation.wos 13
hcfmusp.affiliation.country Brasil


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