Association between psoriasis and coronary calcium score

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP STANIAK, Henrique L. FMUSP-HC
SANTOS, Itamar de Souza FMUSP-HC
BENSENOR, Isabela M. FMUSP-HC 2014
dc.identifier.citation ATHEROSCLEROSIS, v.237, n.2, p.847-852, 2014
dc.identifier.issn 0021-9150
dc.description.abstract Background: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). Objective: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). Methods: We investigated 221 participants with psoriasis and 718 age-and sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam. Logistic regression models adjusted for Framingham risk score (FRS) and C-reactive protein (hs-CRP) were built. CAC was included in the models as a binary variable with different cut off values. Results: Body-mass index, race, hypertension, HDL, LDL and hs-CRP were significantly associated with psoriasis presence and severity. Psoriasis severity was significantly associated with CAC (p = 0.04), particularly for very high CAC (>400) (p <0.01). The OR for severe psoriasis and CAC >400 was 2.45 (95%CI: 1.26-4.75) in unadjusted models. In a model adjusted for the FRS, this association was no longer significant, but a trend was noted (p = 0.09). No significant changes in the association were noted after the inclusion of hs-CRP in the model. Conclusion: Psoriasis is associated with higher CAC values, mainly in individuals with severe psoriasis. The current findings also suggest the potential involvement of other mechanisms beyond classical cardiovascular risk factors and inflammation in this association.
dc.description.sponsorship · CNPq
· Fundacao para Amparo a Pesquisa do Estado de Sao Paulo, Sao Paulo, Brazil [2011/7601-4, 2011/12256-4]
· Brazilian Ministry of Health (Science and Technology Department), Brasilia, Brazil [FINEP: 06 0115.00 SP]
dc.language.iso eng
dc.relation.ispartof Atherosclerosis
dc.rights restrictedAccess
dc.subject Coronary artery calcium; Cardiovascular disease; Cardiovascular risk factors; Psoriasis; Subclinical atherosclerosis
dc.subject.other subclinical atherosclerosis; artery-disease; risk-factors; arthritis; prevalence; health
dc.title Association between psoriasis and coronary calcium score
dc.type article
dc.rights.holder Copyright ELSEVIER IRELAND LTD LIM/51
dc.identifier.doi 10.1016/j.atherosclerosis.2014.11.004
dc.identifier.pmid 25463132
dc.type.category original article
dc.type.version publishedVersion STANIAK, Henrique L.:HU:DVCLME-62 BITTENCOURT, Marcio Sommer:FM: SANTOS, Itamar de Souza:FM:MCM SABBAG, Cid:FM: GOULART, Alessandra C.:HC:LIM/51 LOTUFO, Paulo A.:FM:MCM BENSENOR, Isabela M.:FM:MCM · SHAROVSKY, Rodolfo:Univ Sao Paulo, Univ Hosp, Div Internal Med, BR-05508 Sao Paulo, Brazil; Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, BR-05508 Sao Paulo, Brazil 2-s2.0-84911123142 WOS:000346066600101 CLARE IRELAND
hcfmusp.relation.reference · AGATSTON AS, 1990, J AM COLL CARDIOL, V15, P827
· Antonucci V.A., 2012, J EUR ACAD DERMATOL, V28, P512
· Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
· Armstrong AW, 2012, AM J CARDIOL, V109, P976, DOI 10.1016/j.amjcard.2011.11.025
· Armstrong AW, 2013, J HYPERTENS, V31, P433, DOI 10.1097/HJH.0b013e32835bcce1
· Atzeni F, 2011, J RHEUMATOL, V38, P1661, DOI 10.3899/jrheum.100893
· Balci D.D., 2009, EUR ACAD DERMATOL VE, V23, P1
· Coto-Segura P., 2013, BR J DERMATOL, V91
· Dowlatshahi EA, 2013, J INVEST DERMATOL, V133, P2347, DOI 10.1038/jid.2013.131
· Dowlatshahi E.A., 2013, BR J DERMATOL, V168
· Eder L., 2013, ANN RHEUM DIS, V73, P1990
· Eder L, 2008, J RHEUMATOL, V35, P877
· Enany B., 2012, HERZ, V5, P527
· Finlay AY, 2005, BRIT J DERMATOL, V152, P861, DOI 10.1111/j.1365-2133.2005.06502.x
· Gaeta M., 2013, INT J CARDIOL
· Gelfand JM, 2005, ARCH DERMATOL, V141, P1537, DOI 10.1001/archderm.141.12.1537
· Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
· Gonzalez-Juanatey C, 2007, ARTHRIT RHEUM-ARTHR, V57, P1074, DOI 10.1002/art.22884
· Kaul M.S., 2012, ARTHRIT CARE RES, V65, P266
· Kimhi O., 2007, ARTHRITIS RHEUM, V36, P203
· Kurd SK, 2009, J AM ACAD DERMATOL, V60, P218, DOI 10.1016/j.jaad.2008.09.022
· Ludwig RJ, 2007, BRIT J DERMATOL, V156, P271, DOI 10.1111/j.1365-2133.2006.07562.x
· Mehta NN, 2010, EUR HEART J, V31, P1000, DOI 10.1093/eurheartj/ehp567
· Patel RV, 2011, J GEN INTERN MED, V26, P1036, DOI 10.1007/s11606-011-1698-5
· Pitzalis C, 1998, BRIT J RHEUMATOL, V37, P480
· Tam LS, 2008, ARTHRIT RHEUM-ARTHR, V59, P1322, DOI 10.1002/art.24014
· The Centers for Disease Control and Prevention, 2004, NAT HLTH NUTR EX SUR
· Troitzsch P, 2012, ATHEROSCLEROSIS, V225, P486, DOI 10.1016/j.atherosclerosis.2012.09.026
· Warrington KJ, 2005, ARTHRITIS RES THER, V7, pR984, DOI 10.1186/ar1775
· Wilson PWF, 1998, CIRCULATION, V97, P1837
· Yiu KH, 2013, J INTERN MED, V273, P273, DOI 10.1111/joim.12002
dc.description.index MEDLINE
dc.identifier.eissn 1879-1484
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hcfmusp.citation.wos 17 Brasil

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