Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate
Carregando...
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2014
Editora
HINDAWI PUBLISHING CORPORATION
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
BIOMED RESEARCH INTERNATIONAL, article ID 134236, 8p, 2014
Resumo
The purpose of this study was to characterize the immunopathological response in the skin of S. apella infected with Leishmania (L.) amazonensis and L. (V.) braziliensis parasites, the main causative agents of localized cutaneous leishmaniasis in South America. In infected animals, amastigote forms of L. (L.) amazonensis could be detected till 120 days postinfection (PI), while, in L. (V.) braziliensis infection, parasites could be detected until 180 days PI in the skin sections. CD20(+) cells were detected throughout the experimental time in both groups as well as in CD3(+) cells, which appeared to be activated because high densities of inducible nitric oxide synthase (iNOS(+)) cells were detected at 60 and 90 days PI in both studied groups. After 60 and 120 days PI, decrease in iNOS(+) cells was observed in L. (L.) amazonensis and L. (V.) braziliensis, respectively, which was associated with parasite clearance. Increase in lysozyme(+) cells was observed during the experimental infections, which also can be associated with parasite killing.
Palavras-chave
Referências
- Carvalho AK, 2012, PARASITE IMMUNOL, V34, P395, DOI 10.1111/j.1365-3024.2012.01370.x
- CARVALHO EM, 1995, AM J TROP MED HYG, V53, P273
- Colmenares Maria, 2002, Trans R Soc Trop Med Hyg, V96 Suppl 1, pS3, DOI 10.1016/S0035-9203(02)90044-1
- Garcez LM, 1997, ACTA TROP, V68, P65, DOI 10.1016/S0001-706X(97)00078-8
- Gomes-Silva A, 2013, PARASITOLOGY, V140, P771, DOI 10.1017/S0031182012002156
- GUTIERREZ Y, 1991, AM J TROP MED HYG, V45, P281
- KING FA, 1988, SCIENCE, V240, P1475, DOI 10.1126/science.3287624
- McMahon-Pratt D, 2004, IMMUNOL REV, V201, P206, DOI 10.1111/j.0105-2896.2004.00190.x
- Moore JWJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034143
- Passero LFD, 2009, PARASITOL RES, V105, P1741, DOI 10.1007/s00436-009-1614-7
- PIRMEZ C, 1993, J CLIN INVEST, V91, P1390, DOI 10.1172/JCI116341
- Rodriguez-Pinto D, 2005, CELL IMMUNOL, V238, P67, DOI 10.1016/j.cellimm.2006.02.005
- Shweash M, 2011, MOL IMMUNOL, V48, P1800, DOI 10.1016/j.molimm.2011.05.013
- Silveira F.T., 1989, Revista da Sociedade Brasileira de Medicina Tropical, V22, P125
- Silveira F.T., 1990, Revista da Sociedade Brasileira de Medicina Tropical, V23, P5
- Silveira FT, 2009, PARASITE IMMUNOL, V31, P423, DOI 10.1111/j.1365-3024.2009.01116.x
- SILVEIRA FT, 1990, REV I MED TROP, V32, P387, DOI 10.1590/S0036-46651990000600001
- Silveira FT, 2004, MEM I OSWALDO CRUZ, V99, P239, DOI 10.1590/S0074-02762004000300001
- Souza-Lemos C, 2011, VET IMMUNOL IMMUNOP, V142, P147, DOI 10.1016/j.vetimm.2011.05.002
- Strazzulla A, 2013, BIOMED RES INT, DOI 10.1155/2013/805108
- Swaminathan R, 2011, ADV PROTEIN CHEM STR, V84, P63, DOI 10.1016/B978-0-12-386483-3.00003-3
- Van Assche T, 2011, FREE RADICAL BIO MED, V51, P337, DOI 10.1016/j.freeradbiomed.2011.05.011
- Viana AG, 2013, AN BRAS DERMATOL, V88, P32, DOI 10.1590/S0365-05962013000100003
- Wanasen N, 2008, INT J PARASITOL, V38, P417, DOI 10.1016/j.ijpara.2007.08.010
- Wiesner J, 2010, VIRULENCE, V1, P440, DOI 10.4161/viru.1.5.12983