Perfil epidemiológico da espondiloartrite de início juvenil comparada com a espondiloartrite de início na vida adulta em uma grande coorte brasileira
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Citações na Scopus
10
Tipo de produção
article
Data de publicação
2014
Editora
ELSEVIER SCIENCE INC
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Título do Volume
Autores
DUARTE, Angela P.
MARQUES, Claudia D. L.
BORTOLUZZO, Adriana B.
SILVA, Jose Antonio Braga da
XIMENES, Antonio Carlos
BERTOLO, Manoel B.
RIBEIRO, Sandra Lucia E.
KEISERMAN, Mauro
SKARE, Thelma L.
Autor de Grupo de pesquisa
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Citação
REVISTA BRASILEIRA DE REUMATOLOGIA, v.54, n.6, p.424-430, 2014
Resumo
Objective: To analyze the clinical and epidemiologic characteristics ofjuvenile-onset spondyloarthritis (SpA) (<16 years) and compare them with a group of adult-onset (> 16 years) SpA patients. Patients and methods: Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset < 16 years (JOSpA group) and age at onset 16 years (A0SpA group). Results: Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p <0.001), lower limb arthritis (p = 0.001), enthesitis (p = 0.008), anterior uveitis (p = 0.041) and positive HLA-B27 (p = 0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI; p = 0.007) and functionality (Bath Ankylosing Spondylitis Functional Index - BASFI; p = 0.036). Cutaneous psoriasis (p <0.001), inflammatory bowel disease (p = 0.023), dactylitis (p = 0.024) and nail involvement (p = 0.004) were more frequent in patients with adult-onset SpA. Conclusions: Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.
Palavras-chave
Juvenile-onset spondyloarthritis, Brazilian population, Epidemiology, Chronic arthritis in childhood, Enthesitis-related arthritis
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