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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MORAES, Claudia Trigo Pedroso | - |
dc.contributor.author | OLIVEIRA, Danielle Bruna Leal | - |
dc.contributor.author | CAMPOS, Angelica Cristine Almeida | - |
dc.contributor.author | BOSSO, Patricia Alves | - |
dc.contributor.author | LIMA, Hildener Nogueira | - |
dc.contributor.author | STEWIEN, Klaus Eberhard | - |
dc.contributor.author | GILIO, Alfredo Elias | - |
dc.contributor.author | VIEIRA, Sandra Elisabete | - |
dc.contributor.author | BOTOSSO, Viviane Fongaro | - |
dc.contributor.author | DURIGON, Edison Luiz | - |
dc.date.accessioned | 2015-07-01T20:32:33Z | - |
dc.date.available | 2015-07-01T20:32:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | MEMORIAS DO INSTITUTO OSWALDO CRUZ, v.110, n.1, p.138-141, 2015 | - |
dc.identifier.issn | 0074-0276 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/9428 | - |
dc.description.abstract | Human respiratory syncytial virus (HRSV) is an important respiratory pathogens among children between zero-five years old. Host immunity and viral genetic variability are important factors that can make vaccine production difficult. In this work, differences between biological clones of HRSV were detected in clinical samples in the absence and presence of serum collected from children in the convalescent phase of the illness and from their biological mothers. Viral clones were selected by plaque assay in the absence and presence of serum and nucleotide sequences of the G2 and F2 genes of HRSV biological clones were compared. One non-synonymous mutation was found in the F gene (Ile5Asn) in one clone of an HRSV-B sample and one non-synonymous mutation was found in the G gene (Ser291Pro) in four clones of the same HRSV-B sample. Only one of these clones was obtained after treatment with the child's serum. In addition, some synonymous mutations were determined in two clones of the HRSV-A samples. In conclusion, it is possible that minor sequences could be selected by host antibodies contributing to the HRSV evolutionary process, hampering the development of an effective vaccine, since we verify the same codon alteration in absence and presence of human sera in individual clones of BR-85 sample. | - |
dc.description.sponsorship | FAPESP | - |
dc.language.iso | eng | - |
dc.publisher | FUNDACO OSWALDO CRUZ | - |
dc.relation.ispartof | Memorias do Instituto Oswaldo Cruz | - |
dc.rights | openAccess | - |
dc.subject | HRSV | - |
dc.subject | genetic variability | - |
dc.subject | immune selection pressure | - |
dc.subject.other | neutralization | - |
dc.subject.other | pathogenesis | - |
dc.subject.other | antibodies | - |
dc.subject.other | infection | - |
dc.title | Genetic variability in G2 and F2 region between biological clones of human respiratory syncytial virus with or without host immune selection pressure | - |
dc.type | article | - |
dc.rights.holder | Copyright FUNDACO OSWALDO CRUZ | - |
dc.identifier.doi | 10.1590/0074-02760140299 | - |
dc.identifier.pmid | 25742274 | - |
dc.subject.wos | Parasitology | - |
dc.subject.wos | Tropical Medicine | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | MORAES, Claudia Trigo Pedroso:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil; Inst Butantan, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | OLIVEIRA, Danielle Bruna Leal:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | CAMPOS, Angelica Cristine Almeida:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | BOSSO, Patricia Alves:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | LIMA, Hildener Nogueira:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | STEWIEN, Klaus Eberhard:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | BOTOSSO, Viviane Fongaro:Inst Butantan, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | DURIGON, Edison Luiz:Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, SP, Brazil | - |
hcfmusp.description.beginpage | 138 | - |
hcfmusp.description.endpage | 141 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 110 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84923174252 | - |
hcfmusp.origem.id | WOS:000350699000014 | - |
hcfmusp.origem.id | SCIELO:S0074-02762015000100138 | - |
hcfmusp.publisher.city | RIO DE JANEIRO, RJ | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1678-8060 | - |
hcfmusp.citation.scopus | 0 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPE |
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art_MORAES_Genetic_variability_in_G2_and_F2_region_between_2015.PDF | publishedVersion (English) | 221.71 kB | Adobe PDF | View/Open |
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