Serum lipids in Brazilian children and adolescents: determining their reference intervals

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SLHESSARENKO, Natasha
JACOB, Cristina M. A. FMUSP-HC
AZEVEDO, Raymundo S. FMUSP-HC
FONTES, Cor J. F.
NOVAK, Glaucia V. FMUSP-HC
ANDRIOLO, Adagmar
dc.date.issued 2015
dc.identifier.citation BMC PUBLIC HEALTH, v.15, article ID 18, 8p, 2015
dc.identifier.issn 1471-2458
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/9441
dc.description.abstract Background: Demographic, geographic, environmental and genetic factors influence lipids. In many countries, the normal lipid ranges for laboratory tests are based on references from American children and adolescents. In this work, we determined the reference intervals (RIs) for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein cholesterol (nHDL-c), low-density lipoprotein cholesterol (LDL-c) and triglycerides (TG) in Brazilian healthy children and adolescents. Methods: A cross-sectional study was conducted of 1,866 randomly sampled healthy children and adolescents from kindergartens and schools. Blood samples were collected after a variable period of fasting based on the age of the participant. The upper cut-off points were the 75th and 95th percentiles for TC, nHDL-c, LDL-c and TG. The 10th percentile (low) was used as the bottom level for HDL-c. Non-parametric tests were used for statistical analyses. Results: The following RI and 75th and 95th percentiles were observed for each age interval. The 95th percentile values obtained for TC were: 1 to 2 years, 189 mg/dL, 3 to 8 years, 199 mg/dL; 9 to 12 years, 205 mg/dL. For the nHDL c, the only age group 1 to 12 years, this percentile value was 150 mg/dL. For the LDL-cholesterol, the values corresponding to the percentiles above, aged 1 to 8 years and 9 to 12 years, were 132 mg/dL 139 mg/dL, respectively. For the triglycerides, the values corresponding to 95th percentile were: 1 year, 189 mg/dL; 2 to 5 years, 139 mg/dL; 6 to 12 years, 139 mg/dL. The 10th percentiles for HDL-c were 24 mg/dL, 28 mg/dL, 32 mg/dL and 36 mg/dL for children 1, 2, 3 and 4-12 years old, respectively. Conclusions: The lipid reference intervals defined in the studied Brazilian children and adolescents differ from those recommended by the international literature and should be used for clinical decisions contributing to improve the diagnosis in this particular group in our country.
dc.description.sponsorship · Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [-PQ2-308105/2012-5]
· Nucleo de Apoio a Pesquisa-USP (NAP-CriAd USP)
dc.language.iso eng
dc.publisher BIOMED CENTRAL LTD
dc.relation.ispartof BMC Public Health
dc.rights openAccess
dc.subject Serum lipids; Reference intervals; Child; Adolescent
dc.subject.other pediatric reference intervals; childhood; schoolchildren; cholesterol; prevention; guidelines; profile
dc.title Serum lipids in Brazilian children and adolescents: determining their reference intervals
dc.type article
dc.rights.holder Copyright BIOMED CENTRAL LTD
dc.description.group LIM/01
dc.description.group LIM/36
dc.identifier.doi 10.1186/s12889-015-1359-4
dc.identifier.pmid 25587248
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author JACOB, Cristina M. A.:FM:MPE
hcfmusp.author AZEVEDO, Raymundo S.:FM:MPT
hcfmusp.author NOVAK, Glaucia V.:HC:ICR
hcfmusp.author.external · SLHESSARENKO, Natasha:Univ Fed Mato Grosso, Julio Muller Sch Hosp, Cuiaba, MT, Brazil
· FONTES, Cor J. F.:Univ Fed Mato Grosso, Julio Muller Sch Hosp, Cuiaba, MT, Brazil
· ANDRIOLO, Adagmar:Univ Fed Sao Paulo, Dept Med, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84939185823
hcfmusp.origem.id WOS:000349415300002
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 1
hcfmusp.affiliation.country Brasil


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