Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author TOPORCOV, Tatiana Natasha
ZNAOR, Ariana
ZHANG, Zuo-Feng
YU, Guo-Pei
WINN, Deborah M.
WEI, Qingyi
SMITH, Elaine
SCHWARTZ, Stephen M.
SCHANTZ, Stimson
RAMROTH, Heribert
OLSHAN, Andrew F.
MUSCAT, Joshua
MCCLEAN, Michael
MATSUO, Keitaro
LEVI, Fabio
LAGIOU, Pagona
HERRERO, Rolando
HEALY, Claire
HAYES, Richard B.
DAUDT, Alexander W.
CURIONI, Otavio Alberto
MASO, Luigino Dal
CURADO, Maria Paula
CONWAY, David I.
CANOVA, Cristina
CADONI, Gabriella
BOCCIA, Stefania
ANTUNES, Jose Leopoldo Ferreira
AHRENS, Wolfgang
AGUDO, Antonio
LEE, Yuan-Chin Amy
dc.date.issued 2015
dc.identifier.citation INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, v.44, n.1, p.169-185, 2015
dc.identifier.issn 0300-5771
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/9449
dc.description.abstract Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. Methods: We pooled data from 25 case-control studies and conducted separate analyses for adults <= 45 years old ('young adults', 2010 cases and 4042 controls) and > 45 years old ('older adults', 17 700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, =19.9% (95% CI = 9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking = 5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR = 2.27 (95% CI = 1.26, 4.10)], but not in the older adults [OR = 1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2 .41%, 5.80%) in older adults. Conclusions: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.
dc.description.sponsorship · US National Institutes of Health
· National Cancer Institute [R03CA113157]
· National Institute of Dental and Craniofacial Health [R03DE016611]
· Italian Association for Research on Cancer (AIRC)
· Italian League Against Cancer
· Italian Ministry of Research
· Swiss League against Cancer [KFS1069-09-2000]
· Fribourg League against Cancer [FOR381.88]
· Swiss Cancer Research [AKT 617]
· Gustave-Roussy Institute [88D28]
· Swiss League against Cancer
· Swiss Research against Cancer/Oncosuisse [KFS-700, OCS-1633]
· World Cancer Research Fund
· European Commission INCO-COPERNICUS Program [IC15-CT98-0332]
· National Institutes of Health (NIH) US [P01CA068384 K07CA104231, R01CA078609, R01CA100679]
· NIH [R01CA048996, R01DE012609, NIDCR R01DE11979, NIDCR R01DE13110, NIH FIRCA TW01500, R01CA61188, P01CA068384, K07CA104231, R01DE13158, P50CA90388, R01DA11386, R03CA77954, T32CA09142, U01CA96134, R21ES011667, R01ES11740, R01CA100264, R01CA51845, R01CA30022]
· Veterans Affairs Merit Review Funds
· National Institute of Environmental Health Sciences [P30ES010126]
· Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
· National Institutes of Health (NCI) US
· NIDCR intramural programmes
· Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina
· IMIM (Barcelona)
· Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) [01/01768-2]
· European Commission [IC18-CT97-0222]
· IARC multicentre study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [FIS 97/0024, FIS 97/0662, BAE 01/5013]
· International Union Against Cancer (UICC)
· Yamagiwa-Yoshida Memorial International Cancer Study Grant
· AIRC (Italian Agency for Research on Cancer) [10068]
· US multicentre study: the Intramural Program of the NCI, NIH, United States
· Sao Paulo study: Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) [04/12054-9, 10/51168-0]
· European Community [QLK1-CT-2001-00182]
· German Ministry of Education and Research [01GB9702/3]
· Ministry of Education, Science, Sports, Culture and Technology of Japan [17015052]
· Ministry of Health, Labour and Welfare of Japan [H20-002]
dc.language.iso eng
dc.publisher OXFORD UNIV PRESS
dc.relation.ispartof International Journal of Epidemiology
dc.rights openAccess
dc.subject Head and neck neoplasms; adult; smoking; alcohol drinking; diet
dc.subject.other squamous-cell carcinoma; upper aerodigestive tract; aged 45 years; oral-cancer; pharyngeal cancer; tobacco use; epidemiology consortium; genetic susceptibility; human-papillomavirus; international head
dc.title Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium
dc.type article
dc.rights.holder Copyright OXFORD UNIV PRESS
dc.description.group LIM/28
dc.description.group LIM/38
dc.identifier.doi 10.1093/ije/dyu255
dc.identifier.pmid 25613428
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author ELUF-NETO, Jose:FM:MPR
hcfmusp.author MOYSES, Raquel Ajub:HC:LIM/28
hcfmusp.author.external · TOPORCOV, Tatiana Natasha:Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo, SP, Brazil
· ZNAOR, Ariana:Croatian Natl Canc Registry, Zagreb, Croatia
· ZHANG, Zuo-Feng:Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
· YU, Guo-Pei:Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China; New York Med Coll, Valhalla, NY 10595 USA
· WINN, Deborah M.:NCI, Bethesda, MD 20892 USA
· WEI, Qingyi:UT MD Anderson Canc Ctr, Houston, TX USA
· VILENSKY, Marta:Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina
· VAUGHAN, Thomas:Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA; Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
· THOMSON, Peter:Univ Newcastle, Sch Dent Sci, Newcastle Upon Tyne, Tyne & Wear, England
· TALAMINI, Renato:Aviano Canc Ctr, I-33081 Aviano, Italy
· SZESZENIA-DABROWSKA, Neonila:Inst Occupat Med, Lodz, Poland
· STURGIS, Erich M.:UT MD Anderson Canc Ctr, Houston, TX USA
· SMITH, Elaine:Univ Iowa, Coll Publ Hlth, Iowa City, IA USA
· SHANGINA, Oxana:Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia
· SCHWARTZ, Stephen M.:Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA; Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
· SCHANTZ, Stimson:New York Eye & Ear Infirm, New York, NY 10003 USA
· RUDNAI, Peter:Natl Inst Environm Hlth, Budapest, Hungary
· RICHIARDI, Lorenzo:Univ Turin, Canc Epidemiol Unit, Dept Med Sci, Turin, Italy
· RAMROTH, Heribert:Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany
· PURDUE, Mark P.:NCI, Bethesda, MD 20892 USA
· OLSHAN, Andrew F.:Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA
· MUSCAT, Joshua:Penn State Coll Med, Hershey, PA USA
· MORGENSTERN, Hal:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA; Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA; Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
· MENEZES, Ana:Univ Fed Pelotas, Pelotas, Brazil
· MCCLEAN, Michael:Boston Univ, Sch Publ Hlth, Boston, MA USA
· MATSUO, Keitaro:Aichi Canc Ctr, Res Inst, Nagoya, Aichi 464, Japan
· MATES, Dana:Inst Publ Hlth, Bucharest, Romania
· MACFARLANE, Tatiana V.:Univ Aberdeen, Sch Dent, Aberdeen, Scotland
· LISSOWSKA, Jolanta:M Skasodowska Curie Mem Canc Ctr, Warsaw, Poland; Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland
· LEVI, Fabio:CHU Vaudois, IUMSP, CH-1011 Lausanne, Switzerland; Univ Lausanne, Lausanne, Switzerland
· LAZARUS, Philip:Washington State Univ, Coll Pharm, Spokane, WA USA
· VECCHIA, Carlo La:Ist Ric Farmacol Mario Negri, IRCCS, Milan, Italy; Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
· LAGIOU, Pagona:Univ Athens, Sch Med, GR-11527 Athens, Greece
· KOIFMAN, Sergio:Fundacao Osvvaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro, Brazil
· KJAERHEIM, Kristina:Canc Registry Norway, Oslo, Norway
· KELSEY, Karl:Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
· HOLCATOVA, Ivana:Charles Univ Prague, Fac Med 1, Prague, Czech Republic
· HERRERO, Rolando:WHO, Int Agcy Res Canc, Prevent & Implementat Grp, Lyon, France
· HEALY, Claire:Trinity Coll Sch Dent Sci, Dublin, Ireland
· HAYES, Richard B.:NYU, Sch Med, Div Epidemiol, New York, NY USA
· FRANCESCHI, Silvia:Int Agcy Res Canc, F-69372 Lyon, France
· FERNANDEZ, Leticia:Inst Oncol & Radiobiol, Havana, Cuba
· FABIANOVA, Eleonora:Reg Author Publ Hlth Banska Bystrica, Banska Bystrica, Slovakia
· DAUDT, Alexander W.:Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
· CURIONI, Otavio Alberto:Secretaria Estado Saude Sao Paulo, Hosp Heliopolis, Sao Paulo, Brazil
· MASO, Luigino Dal:Aviano Canc Ctr, I-33081 Aviano, Italy
· CURADO, Maria Paula:Int Prevent Res Inst, Lyon, France
· CONWAY, David I.:Univ Glasgow, Sch Dent, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland
· CANOVA, Cristina:Univ Padua, Padua, Italy
· CADONI, Gabriella:Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome, Italy
· BRENNAN, Paul:Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
· BOCCIA, Stefania:Univ Cattolica Sacro Cuore, Inst Publ Hlth, Rome, Italy
· ANTUNES, Jose Leopoldo Ferreira:Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo, SP, Brazil
· AHRENS, Wolfgang:BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany; Univ Bremen, Inst Stat, Fac Math & Comp Sci, D-28359 Bremen, Germany
· AGUDO, Antonio:IDIBELL, ICO, Barcelona, Spain
· BOFFETTA, Paolo:Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
· HASHIBE, Mia:Univ Utah, Sch Med, Huntsnnan Canc Inst, Salt Lake City, UT USA
· LEE, Yuan-Chin Amy:Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 USA
· WUENSCH FILHO, Victor:Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo, SP, Brazil
hcfmusp.origem.id 2-s2.0-84924584545
hcfmusp.origem.id WOS:000350864200024
hcfmusp.publisher.city OXFORD
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
dc.identifier.eissn 1464-3685
hcfmusp.citation.scopus 60
hcfmusp.citation.wos 54
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