Physicochemical properties and toxicological assessment of modified CdS nanoparticles

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art_SILVA_Physicochemical_properties_and_toxicological_assessment_of_modified_CdS_2014.PDF (762.41 KB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2014
Editora
SPRINGER
DOI
Indexadores
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Autores
SILVA, Andrea R. da
AUCELIO, Ricardo Q.
RODRIGUEZ-COTTO, Rosa I.
ORTIZ-MARTINEZ, Mario G.
RIVERA-RAMIREZ, Evasomary
FRIAS, Daniela Perroni
JIMENEZ-VELEZ, Braulio
GIODA, Adriana
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF NANOPARTICLE RESEARCH, v.16, n.10, article ID 2655, 11p, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cadmium sulfite (CdS) nanoparticles (NPs) modified with different stabilizing agents (2-mercaptopropionic acid or 2MPA, 3-mercaptopropionic acid or 3MPA, and L-cysteine or cys) were designed to be used as luminescent probes. The toxicity and inflammatory response of luminescent CdS NPs (average diameter between 2 and 3 nm) was evaluated ""in vitro"" using human lung epithelial cells (BEAS-2B). Also, mucociliary function changes or injuries were assessed by mucociliary transport (MCT) and ciliary beat frequency (CBF) measurements using frog palates. Toxicity assays showed that Cd concentrations above 1.0 mg L-1 were toxic to BEAS-2B, while Cd associated to NPs was not toxic at the concentrations tested (fivefolds that of Cd toxicity). Cadmium at toxic levels of 2.5 mg L-1 significantly induced the release of both cytokines, IL-6 and IL-8, conversely none toxic levels (2.5 mg L-1) of 2MPA-CdS nanoparticles showed similar effects. However, cys-CdS and 3MPA-CdS NPs did not induce the secretions of either IL-6 or IL-8 by lung epithelial cells at the same Cd concentration of 2.5 mg L-1. Conversely, significant reduction in the secretion of these two pro-inflammatory cytokines was observed. The MCT and CBF results revealed no impairment on mucociliary behavior except a very slight change in mucus viscosity by 3MPA-CdS NPs. These findings highlight the potential of 3MPA-CdS and cys-CdS NPs for future biomedical research, and encourage further histopathological and metabolic studies in order to strengthen that possibility.
Palavras-chave
Quantum dots, Cytotoxicity, Cytokines, Mucociliar transport, Ciliary beat frequency, Environmental and health effects
URI
https://observatorio.fm.usp.br/handle/OPI/9487
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - LIM/05