Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/9489
Title: CORRELATION BETWEEN THE EXPRESSION OF VEGF AND SURVIVAL IN OSTEOSARCOMA
Authors: BAPTISTA, Andre MathiasCAMARGO, Andre Ferrari de FrancaFILIPPI, Renee ZonOLIVEIRA, Claudia Regina Gomes Cardim Mendes deAZEVEDO NETO, Raymundo Soares deCAMARGO, Olavo Pires de
Citation: ACTA ORTOPEDICA BRASILEIRA, v.22, n.5, p.250-255, 2014
Abstract: Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall survival, disease-free survival and local recurrence. Methods: Fifty cases of non-metastatic osteosarcoma of the extremities treated between 1986 and 2006 at Instituto de Ortopedia e Traumatologia da Universidade de Sao Paulo, Sao Paulo, Brasil, were evaluated regarding expression of the VEGF protein. There were 19 females and 31 males. The mean age was 16 years old (range 5-28 years old) and the mean follow-up was 60.6 months (range 25-167 months). The variables studied were age, gender, anatomic location, type of surgery, surgical margins, tumor size, post chemotherapy necrosis, local recurrence, pulmonary metastasis and death. Results: Thirty-six patients showed VEGF expression on 30% or less cells (low), and the remaining 14 cases had VEGF expression above 30% (high). Among the 36 patients with low VEGF expression, nine developed pulmonary metastasis and four died (11.1%). Among the 14 patients with high VEGF expression, six developed pulmonary metastasis and three died (21.4%). Conclusion: There was no statistically significant correlation between the expression of VEGF and any of the variables studied.
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Artigos e Materiais de Revistas Científicas - FM/MOT
Departamento de Ortopedia e Traumatologia - FM/MOT

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/IOT
Instituto de Ortopedia e Traumatologia - HC/IOT

Artigos e Materiais de Revistas Científicas - LIM/01
LIM/01 - Laboratório de Informática Médica

Artigos e Materiais de Revistas Científicas - LIM/41
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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