Burnt sugarcane harvesting is associated with acute renal dysfunction

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art_SANTOS_Burnt_sugarcane_harvesting_is_associated_with_acute_renal_2015.PDF (644.06 KB)
Citações na Scopus
95
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
ZANETTA, Dirce Maria T.
Citação
KIDNEY INTERNATIONAL, v.87, n.4, p.792-799, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Sugarcane harvesting has been associated with an epidemic of chronic kidney disease in Central America mainly affecting previously healthy young workers. Repeated episodes of acute kidney dysfunction are hypothesized to be one of the possible mechanisms for this phenomenon. Therefore, this exploratory study aimed to assess the acute effects of burnt sugarcane harvesting on renal function among 28 healthy non-African Brazilian workers. Urine and blood samples were collected at the beginning and at the end of the harvesting season and before and at the end of a harvesting workday. All individuals decreased their estimated glomerular filtration rate by similar to 20% at the end of the daily shift, and 18.5% presented with serum creatinine increases consistent with acute kidney injury. Those changes were associated with increased serum creatine phosphokinase (a known marker for exertional rhabdomyolysis) and oxidative stress-associated malondialdehyde levels, increased peripheral blood white cell counts, decreased urinary and serum sodium, decreased calculated fractional sodium excretion, and increased urine density. Thus, burnt sugarcane harvesting caused acute renal dysfunction in previously healthy workers. This was associated with a combination of dehydration, systemic inflammation, oxidative stress, and rhabdomyolysis.
Palavras-chave
acute kidney injury, burnt sugarcane harvest, inflammation, oxidative stress, renal function, rhabdomyolysis
URI
https://observatorio.fm.usp.br/handle/OPI/9714
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - LIM/12
Artigos e Materiais de Revistas Científicas - ODS/03
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