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https://observatorio.fm.usp.br/handle/OPI/986| Title: | Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection |
| Authors: | PONTILLO, Alessandra; OSHIRO, Telma M.; GIRARDELLI, Martina; KAMADA, Anselmo J.; CROVELLA, Sergio; DUARTE, Alberto J. S. |
| Citation: | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v.59, n.2, p.121-125, 2012 |
| Abstract: | The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/03 Artigos e Materiais de Revistas Científicas - LIM/56 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| art_PONTILLO_Polymorphisms_in_Inflammasome_Genes_and_Susceptibility_to_HIV_2012_eng.pdf Restricted Access | publishedVersion (English) | 256 kB | Adobe PDF | View/Open Request a copy |
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