Echogenicity as a surrogate for bioresorbable everolimus-eluting scaffold degradation: analysis at 1-, 3-, 6-, 12-18, 24-, 30-, 36-and 42-month follow-up in a porcine model

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Arquivos
art_CAMPOS_Echogenicity_as_a_surrogate_for_bioresorbable_everolimuseluting_scaffold_2015.PDF (1.5 MB)
Citações na Scopus
35
Tipo de produção
article
Data de publicação
2015
Editora
SPRINGER
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
ISHIBASHI, Yuki
EGGERMONT, Jeroen
NAKATANI, Shimpei
CHO, Yun Kyeong
DIJKSTRA, Jouke
REIBER, Johan H. C.
SHEEHY, Alexander
LANE, Jennifer
KAMBERI, Marika
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, v.31, n.3, p.471-482, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The objective of the study is to validate intravascular quantitative echogenicity as a surrogate for molecular weight assessment of poly-l-lactide-acid (PLLA) bioresorbable scaffold (Absorb BVS, Abbott Vascular, Santa Clara, California). We analyzed at 9 time points (from 1- to 42-month follow-up) a population of 40 pigs that received 97 Absorb scaffolds. The treated regions were analyzed by echogenicity using adventitia as reference, and were categorized as more (hyperechogenic or upperechogenic) or less bright (hypoechogenic) than the reference. The volumes of echogenicity categories were correlated with the measurements of molecular weight (Mw) by gel permeation chromatography. Scaffold struts appeared as high echogenic structures. The quantification of grey level intensity in the scaffold-vessel compartment had strong correlation with the scaffold Mw: hyperechogenicity (correlation coefficient = 0.75; P < 0.01), upperechogenicity (correlation coefficient = 0.63; P < 0.01) and hyper + upperechogenicity (correlation coefficient = 0.78; P < 0.01). In the linear regression, the R-2 for high echogenicity and Mw was 0.57 for the combination of hyper and upper echogenicity. IVUS high intensity grey level quantification is correlated to Absorb BVS residual molecular weight and can be used as a surrogate for the monitoring of the degradation of semi-crystalline polymers scaffolds.
Palavras-chave
Absorb, Bioresorbable vascular scaffold, Degradation, Echogenicity, IVUS, Porcine
URI
https://observatorio.fm.usp.br/handle/OPI/9966
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor