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https://observatorio.fm.usp.br/handle/OPI/9998
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MCMURRAY, John | - |
dc.contributor.author | PACKER, Milton | - |
dc.contributor.author | DESAI, Akshay | - |
dc.contributor.author | GONG, Jianjian | - |
dc.contributor.author | GREENLAW, Nicola | - |
dc.contributor.author | LEFKOWITZ, Martin | - |
dc.contributor.author | RIZKALA, Adel | - |
dc.contributor.author | SHI, Victor | - |
dc.contributor.author | ROULEAU, Jean | - |
dc.contributor.author | SOLOMON, Scott | - |
dc.contributor.author | SWEDBERG, Karl | - |
dc.contributor.author | ZILE, Michael R. | - |
dc.contributor.author | ANDERSEN, Karl | - |
dc.contributor.author | ARANGO, Juan Luis | - |
dc.contributor.author | ARNOLD, Malcolm | - |
dc.contributor.author | BELOHLAVEK, Jan | - |
dc.contributor.author | BOEHM, Michael | - |
dc.contributor.author | BOYTSOV, Sergey | - |
dc.contributor.author | BURGESS, Lesley | - |
dc.contributor.author | CABRERA, Walter | - |
dc.contributor.author | CHEN, Chen-Huan | - |
dc.contributor.author | ERGLIS, Andrejs | - |
dc.contributor.author | FU, Michael | - |
dc.contributor.author | GOMEZ, Efrain | - |
dc.contributor.author | GONZALEZ, Angel | - |
dc.contributor.author | HAGEGE, Albert-Alain | - |
dc.contributor.author | KATOVA, Tzvetana | - |
dc.contributor.author | KIATCHOOSAKUN, Songsak | - |
dc.contributor.author | KIM, Kee-Sik | - |
dc.contributor.author | BAYRAM, Edmundo | - |
dc.contributor.author | MARTINEZ, Felipe | - |
dc.contributor.author | MERKELY, Bela | - |
dc.contributor.author | MENDOZA, Ivan | - |
dc.contributor.author | MOSTERD, Arend | - |
dc.contributor.author | NEGRUSZ-KAWECKA, Marta | - |
dc.contributor.author | PEUHKURINEN, Keijo | - |
dc.contributor.author | RAMIRES, Felix | - |
dc.contributor.author | REFSGAARD, Jens | - |
dc.contributor.author | SENNI, Michele | - |
dc.contributor.author | SIBULO JR., Antonio S. | - |
dc.contributor.author | SILVA-CARDOSO, Jose | - |
dc.contributor.author | SQUIRE, Iain | - |
dc.contributor.author | STARLING, Randall C. | - |
dc.contributor.author | VINEREANU, Dragos | - |
dc.contributor.author | TEERLINK, John R. | - |
dc.contributor.author | WONG, Raymond | - |
dc.date.accessioned | 2015-08-14T15:46:58Z | - |
dc.date.available | 2015-08-14T15:46:58Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | EUROPEAN HEART JOURNAL, v.36, n.7, p.434-439, 2015 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/9998 | - |
dc.description.abstract | Aims Although active-controlled trials with reninangiotensin inhibitors are ethically mandated in heart failure with reduced ejection fraction, clinicians and regulators often want to know how the experimental therapy would perform compared with placebo. The angiotensin receptor-neprilysin inhibitor LCZ696 was compared with enalapril in PARADIGM-HF. We made indirect comparisons of the effects of LCZ696 with putative placebos. Methods and results We used the treatment-arm of the Studies Of Left Ventricular Dysfunction (SOLVD-T) as the reference trial for comparison of an ACE inhibitor to placebo and the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity-Alternative trial (CHARM-Alternative) as the reference trial for comparison of an ARB to placebo. The hazard ratio of LCZ696 vs. a putative placebo was estimated through the product of the hazard ratio of LCZ696 vs. enalapril (active-control) and that of the historical active-control (enalapril or candesartan) vs. placebo. For the primary composite outcome of cardiovascular death or heart failure hospitalization in PARADIGM-HF, the relative risk reduction with LCZ696 vs. a putative placebo from SOLVD-T was 43% (95%CI 3450%; P < 0.0001) with similarly large effects on cardiovascular death (34%, 2144%; P < 0.0001) and heart failure hospitalization (49%, 3958%; P < 0.0001). For all-cause mortality, the reduction compared with a putative placebo was 28% (95%CI 1539%; P < 0.0001). Putative placebo analyses based on CHARM-Alternative gave relative risk reductions of 39% (95%CI 2748%; P < 0.0001) for the composite outcome of cardiovascular death or heart failure hospitalization, 32% (95%CI 1645%; P < 0.0001) for cardiovascular death, 46% (3356%; P < 0.0001) for heart failure hospitalization, and 26% (95%CI 1139%; P < 0.0001) for all-cause mortality. Conclusion These indirect comparisons of LCZ696 with a putative placebo show that the strategy of combined angiotensin receptor blockade and neprilysin inhibition led to striking reductions in cardiovascular and all-cause mortality, as well as heart failure hospitalization. These benefits were obtained even though LCZ696 was added to comprehensive background beta-blocker and mineralocorticoid receptor antagonist therapy. | - |
dc.description.sponsorship | Novartis | - |
dc.description.sponsorship | University of Glasgow | - |
dc.language.iso | eng | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.ispartof | European Heart Journal | - |
dc.rights | restrictedAccess | - |
dc.subject | Heart failure | - |
dc.subject | Angiotensin II | - |
dc.subject | Natriuretic peptides | - |
dc.subject.other | active-control trials | - |
dc.subject.other | myocardial-infarction | - |
dc.subject.other | randomized-trial | - |
dc.subject.other | non-inferiority | - |
dc.subject.other | captopril | - |
dc.subject.other | inhibition | - |
dc.subject.other | enalapril | - |
dc.subject.other | mortality | - |
dc.subject.other | survival | - |
dc.subject.other | losartan | - |
dc.title | A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure | - |
dc.type | article | - |
dc.rights.holder | Copyright OXFORD UNIV PRESS | - |
dc.contributor.groupauthor | PARADIGM-HF Comm Investigators | - |
dc.identifier.doi | 10.1093/eurheartj/ehu455 | - |
dc.identifier.pmid | 25416329 | - |
dc.subject.wos | Cardiac & Cardiovascular Systems | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | MCMURRAY, John:Univ Glasgow, British Heart Fdn Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland | - |
hcfmusp.author.external | PACKER, Milton:Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA | - |
hcfmusp.author.external | DESAI, Akshay:Brigham & Womens Hosp, Cardiovasc Med, Boston, MA 02115 USA | - |
hcfmusp.author.external | GONG, Jianjian:Novartis Pharmaceut, E Hanover, NJ USA | - |
hcfmusp.author.external | GREENLAW, Nicola:Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland | - |
hcfmusp.author.external | LEFKOWITZ, Martin:Novartis Pharmaceut, E Hanover, NJ USA | - |
hcfmusp.author.external | RIZKALA, Adel:Novartis Pharmaceut, E Hanover, NJ USA | - |
hcfmusp.author.external | SHI, Victor:Novartis Pharmaceut, E Hanover, NJ USA | - |
hcfmusp.author.external | ROULEAU, Jean:Univ Montreal, Inst Cardiol, Montreal, PQ, Canada | - |
hcfmusp.author.external | SOLOMON, Scott:Brigham & Womens Hosp, Cardiovasc Med, Boston, MA 02115 USA | - |
hcfmusp.author.external | SWEDBERG, Karl:Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden; Univ London Imperial Coll Sci Technol & Med, London, England | - |
hcfmusp.author.external | ZILE, Michael R.:Med Univ S Carolina, Charles Ezra Daniel Prof Med, RHJ Dept VA Med Ctr, Charleston, SC 29425 USA | - |
hcfmusp.author.external | ANDERSEN, Karl:Univ Iceland, Sch Hlth Sci, Cardiovasc Res Ctr, Reykjavik, Iceland | - |
hcfmusp.author.external | ARANGO, Juan Luis:Guatemalan Heart Inst, Guatemala City, Guatemala | - |
hcfmusp.author.external | ARNOLD, Malcolm:Western Univ, Schulich Sch Med & Dent, London Hlth Sci Ctr, Ottawa, ON, Canada | - |
hcfmusp.author.external | BELOHLAVEK, Jan:Charles Univ Prague, Dept Med 2, Cardiovasc Med, Gen Teaching Hosp, Prague, Czech Republic; Charles Univ Prague, Sch Med 1, Prague, Czech Republic; Natl Univ Hearty Ctr, Dept Cardiol, Singapore, Singapore | - |
hcfmusp.author.external | BOEHM, Michael:Univ Saarland, Dept Cardiol, Homburg, Germany | - |
hcfmusp.author.external | BOYTSOV, Sergey:Natl Res Ctr Prevent Med, Moscow, Russia | - |
hcfmusp.author.external | BURGESS, Lesley:Univ Stellenbosch, Cardiol Trial Unit, ZA-7600 Stellenbosch, South Africa | - |
hcfmusp.author.external | CABRERA, Walter:Clin Vesalio, Lima, Peru | - |
hcfmusp.author.external | CHEN, Chen-Huan:Natl Yang Ming Univ, Fac Med, Taipei 112, Taiwan; Taipei Vet Gen Hosp, Dept Med Educ, Div Fac Dev, Taipei, Taiwan | - |
hcfmusp.author.external | ERGLIS, Andrejs:Univ Latvia, Fac Med, Riga, Latvia | - |
hcfmusp.author.external | FU, Michael:Sahlgrens Univ Hosp, Dept Med, Ostra Hosp, Gothenburg, Sweden | - |
hcfmusp.author.external | GOMEZ, Efrain:Clin Shaio, Bogota, Colombia | - |
hcfmusp.author.external | GONZALEZ, Angel:Inst Dominicano Cardiol, Santo Domingo, Dominican Rep | - |
hcfmusp.author.external | HAGEGE, Albert-Alain:Georges Pompidou European Hosp, Dept Cardiol, Paris, France | - |
hcfmusp.author.external | KATOVA, Tzvetana:Natl Cardiol Hosp, Dept Noninvas Cardiovasc Imaging & Funct Diagnost, Sofia, Bulgaria | - |
hcfmusp.author.external | KIATCHOOSAKUN, Songsak:Khon Kaen Univ, Div Cardiol, Khon Kaen, Thailand | - |
hcfmusp.author.external | KIM, Kee-Sik:Daegu Catholic Univ, Med Ctr, Dept Cardiol, Daegu, South Korea | - |
hcfmusp.author.external | BAYRAM, Edmundo:Fdn Cardiovasc Aguascalientes, Ags, Mexico | - |
hcfmusp.author.external | MARTINEZ, Felipe:Inst DAMIC Fdn Rusculleda, Cordoba, Argentina | - |
hcfmusp.author.external | MERKELY, Bela:Semmelweis Univ, Heart & Vasc Ctr, H-1085 Budapest, Hungary | - |
hcfmusp.author.external | MENDOZA, Ivan:Cent Univ Venezuela, Caracas, Venezuela; Cleveland Clin, Kaufman Ctr Heart Failure, Inst Heart & Vasc, Cleveland, OH 44106 USA | - |
hcfmusp.author.external | MOSTERD, Arend:Meander Med Ctr, Dept Cardiol, Amsterdam, Netherlands | - |
hcfmusp.author.external | NEGRUSZ-KAWECKA, Marta:Wroclaw Med Univ, Dept & Clin Cardiol, Wroclaw, Poland | - |
hcfmusp.author.external | PEUHKURINEN, Keijo:Univ Kuopio, Finnish Fdn Cardiovasc Res, FIN-70211 Kuopio, Finland | - |
hcfmusp.author.external | REFSGAARD, Jens:Viborg Hosp, Dept Cardiol, Viborg, Denmark | - |
hcfmusp.author.external | SENNI, Michele:Osped Papa Giovanni XXIII, Cardiovasc Dept, Cardiol 1, Bergamo, Italy | - |
hcfmusp.author.external | SIBULO JR., Antonio S.:St Lukes Heart Inst, Manila, Philippines | - |
hcfmusp.author.external | SILVA-CARDOSO, Jose:Porto Med Sch, Oporto, Portugal | - |
hcfmusp.author.external | SQUIRE, Iain:Univ Leicester, Leicester, Leics, England; NIHR Cardiovasc Res Unit, Leicester, Leics, England | - |
hcfmusp.author.external | STARLING, Randall C.:Cleveland Clin, Kaufman Ctr Heart Failure, Inst Heart & Vasc, Cleveland, OH 44106 USA | - |
hcfmusp.author.external | VINEREANU, Dragos:Univ Med & Pharm Carol Davila Emergency & Univ Ho, Bucharest, Romania | - |
hcfmusp.author.external | TEERLINK, John R.:San Francisco VA Med Ctr, San Francisco, CA USA; Univ Calif San Francisco, San Francisco, CA 94143 USA | - |
hcfmusp.description.beginpage | 434 | - |
hcfmusp.description.endpage | 439 | - |
hcfmusp.description.issue | 7 | - |
hcfmusp.description.volume | 36 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84928634952 | - |
hcfmusp.origem.id | WOS:000351589000015 | - |
hcfmusp.publisher.city | OXFORD | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1522-9645 | - |
hcfmusp.citation.scopus | 78 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/11 |
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