LIM/38 - Laboratório de Epidemiologia e Imunobiologia
URI Permanente desta comunidade
O Laboratório de Epidemiologia e Imunobiologia é ligado ao Departamento de Medicina Preventiva da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Linhas de pesquisa: epidemiologia das neoplasias; epidemiologia da AIDS e outras doenças transmissíveis; imunopatogenia de leishmanioses; métodos diagnósticos e alternativas terapêuticas das doenças negligenciadas; coinfecção HIV/leishmania.
Site oficial: http://limhc.fm.usp.br/portal/lim38-laboratorio-de-epidemiologia-e-imunobiologia/
Linhas de pesquisa: epidemiologia das neoplasias; epidemiologia da AIDS e outras doenças transmissíveis; imunopatogenia de leishmanioses; métodos diagnósticos e alternativas terapêuticas das doenças negligenciadas; coinfecção HIV/leishmania.
Site oficial: http://limhc.fm.usp.br/portal/lim38-laboratorio-de-epidemiologia-e-imunobiologia/
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- LIM/38 - Laboratório de Epidemiologia e Imunobiologia
- LIM/38 - Laboratório de Epidemiologia e Imunobiologia
- LIM/38 - Laboratório de Epidemiologia e Imunobiologia
Submissões Recentes
“Narrativas de Peso”: relato da experiência de construção de um curso educativo sobre estigma relacionado ao peso corporal e o cuidado em saúde
(2023) OLIVEIRA, Luana Cordeiro de; UNSAIN, Ramiro Andrés Fernandez; SOARES, Ariel Regina da Silva; SABATINI, Fernanda; ULIAN, Mariana Dimitrov; SCAGLIUSI, Fernanda Baeza
Weight stigma is defined as the devaluation of people due to their higher body weight, causing harmful effects to health and is present among healthcare undergraduate students and professionals. Addressing weight stigma in training spaces is crucial to fight against it. This article reports the experience about the construction of the educational course “Narratives of Weight: weight stigma and health care”, aimed at healthcare undergraduate students and professionals. Priority was given to the diversity of materials, range of perspectives, language accessibility and the presence of fat people. It is considered that the course’s building process has elements that can guide the development of other powerful and contextualized materials and interventions for the target audience.
HIV/aids: evolução clínica, diagnóstico e abordagens atuais
(2024) LIMONGELLI, Isadora Id; CERCHIARI, Natacha; SEGURADO, Aluisio Cotrim; NISIDA, Isabelle Vera Vichr
Years of Potential Life Lost due to COVID-19 according to race/color and gender in Brazil between 2020 and 2021
(2024) LUIZ, Olinda do Carmo; ARAUJO, Edna Maria de; SOUZA, Ionara Magalhaes de; MAXIMO, Giovanni; QUEIROZ, Franciane de Azevedo; CAVALCANTE, Lara; NISIDA, Vitor
Mortality caused by the COVID-19 pandemic has impacted indicators of Years of Potential Life Lost (YPLL) worldwide. This study aimed to estimate the YPLL due to mortality caused by COVID-19, according to sex, age group, and race/color in Brazil, from March 2020 to December 2021. Deaths caused by COVID-19 were characterized, in which the rates and ratios of standardized YPLL rates, the average number of years of potential life lost (ANYPLL), and the average age at death (AAD) were estimated and compared. Overall, 13,776,969.50 potential years of life were lost, which resulted in an average loss of 22.5 potential years not lived. A greater loss of potential years of life was identified in men (58.12%) and in the age groups from 0 to 59 years in the black (58.92%) and indigenous (63.35%) populations, while in the age groups of 60 years and over, a greater loss of YPLL was observed in the white (45.89%) and yellow (53.22%) populations. Women recorded the highest ADD, with the exception of indigenous women. White men (1.63), brown men (1.59), and black men (1.61) had the highest rates when compared to white women. Although COVID-19 has a greater impact on the elderly, it was the black and indigenous populations under the age of 60 who had the greatest loss of potential years of life.
Implementing a provisional overarching intervention for COVID-19 monitoring and control in the Brazil-Colombia-Peru frontier (vol 11, 1330347, 2024)
(2024) CONTRERAS, Matilde; NAVECA, Felipe Gomes; CARVAJAL-CORTES, Jose Joaquin; FAVIERO, Guilherme F.; SAAVEDRA, Jorge; SANTOS, Eduardo Ruback dos; NASCIMENTO, Valdinete Alves do; SOUZA, Victor Costa de; NASCIMENTO, Fernanda Oliveira do; SILVA, Dejanane Silva e; LUZ, Sergio Luiz Bessa; VESGA, Kelly Natalia Romero; NIETO, Juan Camilo Grisales; AVELINO-SILVA, Vivian I.; BENZAKEN, Adele Schwartz
The impact of cholesteryl ester transfer protein on the progression of cutaneous leishmaniasis
(2024) BATISTA-DANTAS, Francisca Elda; OZAKI, Christiane Yumi; SANTANA, Kelly Gomes; NUNES, Valeria Sutti; USCATA, Bernardina Amorin; SIESS-PORTUGAL, Cinthia; REIS, Luiza Campos; YAMASHIRO-KANASHIRO, Edite H.; TAFURI, Wagner Luiz; DUARTE-NETO, Amaro Nunes; SOTTO, Mirian Nacagami; GOTO, Hiro; CAZITA, Patricia Miralda
Introduction: Pathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation of lipoproteins (LP). The cholesteryl ester transfer protein (CETP), involved in LP remodeling, has been shown to participate in the inflammatory response and the evolution of infectious conditions. Methods: We evaluated the impact of the presence of CETP on infection by Leishmania (L.) amazonensis in an experimental model of cutaneous leishmaniasis using C57BL6/J mice transgenic for human CETP (CETP), having as control their littermates that do not express the protein, wild-type (WT) mice. The progression of the lesion after infection in the footpad was monitored for 12 weeks. Two groups of animals were formed to collect the plantar pad in the 4th and 12th week post-infection. Results: The lesion increased from the 3rd week onwards, in both groups, with a gradual decrease from the 10th week onwards in the CETP group compared to the WT group, showing a reduction in parasitism and an improvement in the healing process, a reduction in CD68+ cells, and an increase in CD163+ and CD206, characterizing a population of M2 macrophages. A reduction in ARG1+ cells and an increase in INOS+ cells were observed. During infection, the LP profile showed an increase in triglycerides in the VLDL fraction in the CETP group at 12 weeks. Gene expression revealed a decrease in the CD36 receptor in the CETP group at 12 weeks, correlating with healing and parasite reduction. In vitro, macrophages derived from bone marrow cells from CETP mice showed lower parasite load at 48 h and, a reduction in arginase activity at 4 h accompanied by increased NO production at 4 and 24 h compared to WT macrophages, corroborating the in vivo findings. Discussion: The data indicate that the presence of CETP plays an important role in resolving Leishmania (L.) amazonensis infection, reducing parasitism, and modulating the inflammatory response in controlling infection and tissue repair.
Association between ultra-processed dietary pattern and bullying: the role of deviant behaviors
(2024) OKADA, Leticia Martins; MARQUES, Emanuele Souza; LEVY, Renata Bertazzi; GONCALVES, Vivian Siqueira Santos; PERES, Maria Fernanda Tourinho; AZEREDO, Catarina Machado
Background Ultra-processed foods have been associated with several negative outcomes, but it is not clear whether they are related to bullying perpetration. Moreover, no previous study has investigated the potential role of deviant behaviors as a mediator of this association. Our objective was to evaluate the association between ultra-processed dietary pattern and bullying, and the mediating effect of deviant behaviors in this association, among school adolescents.Methods We used data from a representative sample of 9th grade Brazilian adolescents (N = 2,212) from the S & atilde;o Paulo Project for the social development of children and adolescents (SP-PROSO). Exploratory factor analysis was used to obtain the dietary patterns, through questions of frequency of consumption in the last week of several foods. The ultra-processed dietary pattern was considered as exposure. The outcomes were the types of bullying (any type, social exclusion, psychological/verbal aggression, physical aggression, property destruction, and sexual harassment). Deviant behaviors (mediator) were assessed through a score. Mediation analyses were carried out using logistic regression based on the KHB method.Results After adjusting for covariates, the mediating effect of deviant behaviors was found in the association between ultra-processed dietary pattern and all the types of bullying perpetration, especially for psychological/verbal aggression (39.4%). A small mediating effect of deviant behaviors in the association of ultra-processed dietary pattern with physical aggression (17.7%) and property destruction (18.5%) was observed, but this effect explained only a small portion of the total effect of such association (significant direct effect).Conclusion The ultra-processed dietary pattern was associated with bullying, and the association was mediated through deviant behaviors. Policies and actions for improving the adolescent's diet and managing the adoption of deviant and bullying behaviors by this public are required. Graphical abstract of the possible mechanisms by which the ultra-processed dietary pattern is associated with the perpetration of bullying. This figure was created using BioRender.com.
I live in a very bourgeois world, I don't live in the outskirts: childhood non-vaccination and the intersection of race, class and gender
(2024) MATOS, Camila Carvalho de Souza Amorim; TAVARES, Jeane Saskya Campos; COUTO, Marcia Thereza
This article analyzes how race, gender, social class and spatiality markers intersect and are reflected in health decision-making, more specifically in childhood (non)vaccination. This qualitative study was conducted in two Brazilian cities: Florian & oacute;polis (SC) and S & atilde;o Lu & iacute;s (MA), and included families with children up to six years old. This article analyzes the narratives of 19 caregivers in Florian & oacute;polis who chose not to vaccinate (fully or partially) the child(ren) under their responsibility. In-depth interviews and thematic content analysis were conducted. Gender was an important marker in intra-family decision-making, while social class, race and spatiality emerged as important markers in the perception of who are the ""us"" who don't need vaccines and the ""others"" who do. The findings are discussed using the theoretical framework of whiteness and neoliberal parenting studies.
I live in a very bourgeois world, I don't live in the outskirts: childhood non-vaccination and the intersection of race, class and gender
(2024) MATOS, Camila Carvalho de Souza Amorim; TAVARES, Jeane Saskya Campos; COUTO, Marcia Thereza
This article analyzes how race, gender, social class and spatiality markers intersect and are reflected in health decision -making, more specifically in childhood (non)vaccination. This qualitative study was conducted in two Brazilian cities: Florian & oacute;polis (SC) and S & atilde;o Lu & iacute;s (MA), and included families with children up to six years old. This article analyzes the narratives of 19 caregivers in Florian & oacute;polis who chose not to vaccinate (fully or partially) the child(ren) under their responsibility. In-depth interviews and thematic content analysis were conducted. Gender was an important marker in intra-family decision -making, while social class, race and spatiality emerged as important markers in the perception of who are the ""us"" who don't need vaccines and the ""others"" who do. The findings are discussed using the theoretical framework of whiteness and neoliberal parenting studies.
Methodological guidelines and publications of benefit-risk assessment for health technology assessment: a scoping review
(2024) SUZUMURA, Erica Aranha; ASCEF, Bruna de Oliveira; MAIA, Fernando Henrique de Albuquerque; BORTOLUZZI, Aline Frossard Ribeiro; DOMINGUES, Sidney Marcel; FARIAS, Natalia Santos; GABRIEL, Franciele Cordeiro; JAHN, Beate; SIEBERT, Uwe; SOAREZ, Patricia Coelho de
Objectives To map the available methodological guidelines and documents for conducting and reporting benefit-risk assessment (BRA) during health technologies' life cycle; and to identify methodological guidelines for BRA that could serve as the basis for the development of a BRA guideline for the context of health technology assessment (HTA) in Brazil. Design Scoping review. Methods Searches were conducted in three main sources up to March 2023: (1) electronic databases; (2) grey literature (48 HTA and regulatory organisations) and (3) manual search and contacting experts. We included methodological guidelines or publications presenting methods for conducting or reporting BRA of any type of health technologies in any context of the technology's life cycle. Selection process and data charting were conducted by independent reviewers. We provided a structured narrative synthesis of the findings. Results From the 83 eligible documents, six were produced in the HTA context, 30 in the regulatory and 35 involved guidance for BRA throughout the technology's life cycle. We identified 129 methodological approaches for BRA in the documents. The most commonly referred to descriptive frameworks were the Problem, Objectives, Alternatives, Consequences, Trade-offs, Uncertainty, Risk and Linked decisions and the Benefit-Risk Action Team. Multicriteria decision analysis was the most commonly cited quantitative framework. We also identified the most cited metric indices, estimation and utility survey techniques that could be used for BRA. Conclusions Methods for BRA in HTA are less established. The findings of this review, however, will support and inform the elaboration of the Brazilian methodological guideline on BRA for HTA.
Prevalence of trachoma in indigenous and nonindigenous areas, Northeastern Brazil, 2019-2021
(2024) GOMEZ, Daniela Vaz Ferreira; ALMEIDA, Wanessa da Silva de; JR, Paulo Roberto Borges de Souza; LOPES, Maria de Fatima Costa; LUNA, Expedito Jose de Albuquerque; ZIMMERMANN, Ivan Ricardo; TAVARES, Noemia Urruth Leao; GUTIERREZ, Maria Margarita Urdaneta; SZWARCWALD, Celia Landmann
Objective. To estimate the prevalence of trachoma in indigenous and non -indigenous populations in selected areas of the state of Maranhao, in northeastern Brazil. Methods. This was a population -based survey with probabilistic sampling. For the diagnosis of trachoma, external ocular examination was performed using head magnifying loupes, at 2.5X magnification. The prevalence of trachomatous inflammation - follicular (TF) in children aged 1-9 years and the prevalence of trachomatous trichiasis (TT) in the population aged >= 15 years were estimated. Relative frequencies of sociodemographic and environmental characteristics were obtained. Results. The study included 7 971 individuals, 3 429 from non -indigenous populations and 4 542 from indigenous populations. The prevalence of TF in non -indigenous and indigenous populations was 0.1% and 2.9%, respectively, and the prevalence of TT among indigenous populations was 0.1%. Conclusions. The prevalence of TF and TT in the two evaluation units in the state of Maranhao were within the limits recommended for the elimination of trachoma as a public health problem. However, the prevalence of TF was higher in the indigenous evaluation unit, indicating a greater vulnerability of this population to the disease. The prevalence of TF of below 5.0% implies a reduction in transmission, which may have resulted from improved socioeconomic conditions and/or the implementation of the World Health Organization SAFE strategy.