JORGE ELIAS KALIL FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
37 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 37
- Sensitization to cat allergen and its association with respiratory allergies: cross-sectional study(2017) GALVAO, Clovis Eduardo Santos; GRAUDENZ, Gustavo Silveira; KALIL, Jorge; CASTRO, Fabio Fernandes MoratoCats are a significant source of allergens that contribute towards worsening of allergic diseases. The aim of this study was to investigate the association between sensitization to cat allergens and allergic respiratory diseases. This was an observational retrospective study based on the skin prick tests results of patients at a tertiary-level hospital in Sao Paulo. A total of 1,985 test results were assessed. The prevalence of sensitization to cat allergen was 20% (399 patients). Our data indicated that in this population of atopic patients, a positive skin prick test result for cat allergen was not associated significantly with a diagnosis of respiratory allergy.
- Chronic Spontaneous Urticaria: Response to Antileukotriene(2017) LOPES, Mariele Morandin; SALLES, Pamella Diogo; DANTAS, Paula; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana Camara
conferenceObject Intradermal test is a relevant biomarker of the outcome of rapid desensitization in penicillin allergy(2017) GARCIA, J. F.; V, M. Aun; MOTTA, A. A.; KALIL, J.; GIAVINA-BIANCHI, P.- MMP9 integrates multiple immunoregulatory pathways that discriminate high suppressive activity of human mesenchymal stem cells(2017) LAVINI-RAMOS, Carolina; SILVA, Hernandez Moura; SOARES-SCHANOSKI, Alessandra; MONTEIRO, Sandra Maria; FERREIRA, Ludmila Rodrigues Pinto; PACANARO, Ana Paula; GOMES, Samirah; BATISTA, Janaina; FAE, Kellen; KALIL, Jorge; COELHO, VeronicaThe mechanisms underlying mesenchymal stem cells' (MSC) suppressive potency are largely unknown. We here show that highly suppressive human adipose tissue-derived MSC (AdMSC) display and induce a differential immunologic profile, upon ongoing AdMSC suppressive activity, promoting: (i) early correlated inhibition of IFN-gamma and TNF-alpha production, along IL-10 increase, (ii) CD73(+) Foxp3(+) Treg subset expansion, and (iii) specific correlations between gene expression increases, such as: MMP9 correlated with CCL22, TNF, FASL, RUNX3, and SEMAD4 in AdMSC and, in T cells, MMP9 upregulation correlated with CCR4, IL4 and TBX21, among others, whereas MMP2 correlated with BCL2 and LRRC31. MMP9 emerged as an integrating molecule for both AdMSC and T cells in molecular networks built with our gene expression data, and we confirmed upregulation of MMP9 and MMP2 at the protein level, in AdMSC and T cells, respectively. MMP2/9 inhibition significantly decreased AdMSC suppressive effect, confirming their important role in suppressive acitivity. We conclude that MMP9 and 2 are robust new players involved in human MSC immunoregulatory mechanisms, and the higher suppressive activity correlates to their capacity to trigger a coordinated action of multiple specific molecules, mobilizing various immunoregulatory mechanisms.
conferenceObject Inflammatory cell response, functional and biochemical features of the airways of professional cleaning workers upon exposure in the workplace(2017) LIMA, Cynthia F. Mafra; SARAIVA, Beatriz M.; KALIL, Jorge; CASTRO, Fabio M.; GALVAO, Clovis Eduardo S.conferenceObject Safety to Extensively Heated Cow's Milk Challenge in Children with Severe Cow's Milk Allergy(2017) CORDOVA, Pablo Torres; PEDROSO, Natalia Falci; MELLO, Marcella Fonseca; SALLES-CUNHA, Patricia; KALIL, Jorge; CASTRO, Fabio M.; YANG, Ariana Campos- Massive bee envenomation(2017) FAN, H. W.; KALIL, J.
conferenceObject POTENTIATION OF BENZNIDAZOLE EFFECT BY COADMINISTRATION OF REPURPOSED DRUGS ACTING IN THE INVASION OF HOST CELLS BY TRYPANOSOMA CRUZI(2017) PANDEY, Ramendra P.; SAVOIA, Marilda; SABINO, Ester; KALIL, Jorge; CUNHA-NETO, EdecioconferenceObject Gender influence on hereditary angioedema with C1-inhibitor deficiency(2017) GARCIA, J. F.; TAKEJIMA, P. M.; V, M. Aun; MOTTA, A. A.; KALIL, J.; GIAVINA-BIANCHI, P.- Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients(2017) TERZIAN, Ana Carolina Bernardes; SCHANOSKI, Alessandra Soares; MOTA, Minh' Tasso de Oliveira; SILVA, Rafael Alves da; ESTOFOLETE, Cassia Fernanda; COLOMBO, Tatiana Elias; RAHAL, Paula; HANLEY, Kathryn A.; VASILAKIS, Nikos; KALIL, Jorge; NOGUEIRAL, Mauricio LacerdaBackground. The pathogenesis of severe dengue disease involves immune components as biomarkers. The mechanism by which some dengue virus (DENV)-infected individuals progress to severe disease is poorly understood. Most studies on the pathogenesis of severe dengue disease focus on the process of antibody-dependent enhancement (ADE) as a primary risk factor. With the circulation of Zika virus (ZIKV) in DENV-endemic areas, many people infected by ZIKV were likely exposed to DENV. The influence of such exposure on Zika disease outcomes remains unknown. Methods. We investigated whether patients previously exposed to DENV exhibited higher viremia when exposed to a subsequent, heterologous dengue or Zika infection than those patients not previously exposed to dengue. We measured viral loads and cytokine profile during patients' acute infections. Results. Neither dengue nor Zika viremia was higher in patients with prior DENV infection, although the power to detect such a difference was only adequate in the ZIKV analysis. Of the 10 cytokines measured, only 1 significant difference was detected: Levels of interleukin 1 beta (IL-1 beta) were lower in dengue-infected patients who had experienced a previous dengue infection than patients infected with dengue for the first time. However, power to detect differences between groups was low. In Zika-infected patients, levels of IL-1 beta showed a significant, positive correlation with viral load. Conclusions. No signs of ADE were observed in vivo in patients with acute ZIKV infection who had prior exposure to DENV.