UBIRATAN DE PAULA SANTOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
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Resultados de Busca
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conferenceObject Impacts of exposure to environmental air pollution on heart rate variability in young athletes(2013) PACELI, Renato; FORTES, Aretusa Cardoso Der; FAIBISCHEW, Gustavo; SA, Matheus; VAISBERG, Mauro; TERRA-FILHO, Mario; SANTOS, Ubiratan de PaulaconferenceObject Smoking status, prevalence of smoking-related diseases and their impact on costs in patients hospitalized in the thoracic units of a tertiary hospital in Brazil(2013) MORAIS, Anna Miethke; LOMBARDI, Elisa Maria Siqueira; PRADO, Gustavo F.; MARTINS, Stella R.; PACELI, Renato; TERRA-FILHO, Mario; SANTOS, Ubiratan de PaulaconferenceObject 6-minute walking test (6MWT) in patients with silicosis(2013) COZZA, Izabela; LOMBARDI, Elisa; PRADO, Gustavo; TERRA, Mario; SANTOS, UbiratanconferenceObject Tobacco use and smoking knowledge: Study among medical students of 3rd and 6th year at Medicine Faculty, University of Sao Paulo(2013) PACELI, Renato; MARTINS, Stella; PRADO, Gustavo Faibischew; MORAIS, Anna; LOMBARDI, Elisa; BUSSACOS, Marcos; TERRA-FILHO, Mario; SANTOS, Ubiratan de Paula- pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers(2013) LIMA, Thamires Marques de; KAZAMA, Cristiane Mayumi; KOCZULLA, Andreas Rembert; HIEMSTRA, Pieter S.; MACCHIONE, Mariangela; FERNANDES, Ana Luisa Godoy; SANTOS, Ubiratan de Paula; BUENO-GARCIA, Maria Lucia; ZANETTA, Dirce Maria; ANDRE, Carmen Diva Saldiva de; SALDIVA, Paulo Hilario Nascimento; NAKAGAWA, Naomi KondoOBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1 beta and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.