UBIRATAN DE PAULA SANTOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
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Resultados de Busca
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- Prevalence and associated factors of experimentation with and current use of water pipes and electronic cigarettes among medical students: a multicentric study in Brazil(2023) MARTINS, Stella Regina; ARAUJO, Alberto Jose de; WEHRMEISTER, Fernando C.; FREITAS, Beatriz Martins; BASSO, Rafaela Giunti; SANTANA, Alfredo Nicodemos Cruz; SANTOS, Ubiratan de PaulaObjective: To evaluate the prevalence of and factors associated with experimentation with and current use of water pipes and e-cigarettes among medical students. Methods: This was a cross-sectional multicentric study involving a convenience sample of students from medical schools in most Brazilian geographic regions. Information about experimentation with and current use of conventional cigarettes, water pipes, and e-cigarettes; beliefs and attitudes toward tobacco products; religiosity; and demographics were collected by means of an online structured questionnaire. We used descriptive statistics and logistic regression to analyze the association of those factors. Results: Our sample comprised 700 individuals from four Brazilian regions. Prevalence of experimentation with and current use of cigarettes, water pipes, and e-cigarettes were, respectively, 39.1% and 7.9%; 42.6% and 11.4%; and 13.1% and 2.3%. Water pipe experimentation was higher among those who had a sibling (adjusted OR = 2.64; 95% CI, 1.24-5.61) or friends (adjusted OR = 2.33; 95% CI, 1.63- 3.31) who smoke. The same occurred regarding e- cigarette experimentation: siblings (adjusted OR = 2.76; 95% CI, 1.17-6.50) and friends (adjusted OR = 2.47; 95% CI, 1:45- 4.22). Curiosity and scent/ taste were the major reasons for water pipe use and e-cigarette experimentation. Although 93% of the responders learned about health damages of smoking during medical school classes, 51.4% reported having experimented with at least one of these tobacco products. Most responders who reported feeling the presence of God/ the Holy Spirit in their lives were never experimenters of water pipes (59.2%) or e-cigarettes (55.3%). Conclusions: There is a high prevalence of experimentation with tobacco products among medical students whose siblings or friends smoke, despite their knowledge about smoking harms.
- Work-related asthma consequences on socioeconomic, asthma control, quality of life, and psychological status compared with non-work-related asthma: A cross-sectional study in an upper-middle-income country(2023) ROIO, Lavinia Clara; STELMACH, Rafael; MIZUTANI, Rafael F. F.; TERRA-FILHO, Mario; SANTOS, Ubiratan d. P.BackgroundWork-related asthma (WRA) is the most prevalent occupational respiratory disease, and it has negative effects on socioeconomic standing, asthma control, quality of life, and mental health status. Most of the studies on WRA consequences are from high-income countries; there is a lack of information on these effects in Latin America and in middle-income countries. MethodsThis study compared socioeconomic, asthma control, quality of life, and psychological outcomes among individuals diagnosed with WRA and non-work-related asthma (NWRA) in a middle-income country. Patients with asthma, related and not related to work, were interviewed using a structured questionnaire to assess their occupational history and socioeconomic conditions, and with questionnaires to assess asthma control (Asthma Control Test and Asthma Control Questionnaire-6), quality of life (Juniper's Asthma Quality of Life Questionnaire), and presence of anxiety and depression symptoms (Hospital Anxiety and Depression Scale). Each patient's medical record was reviewed for exams and use of medication, and comparisons were made between individuals with WRA and NWRA. ResultsThe study included 132 patients with WRA and 130 with NWRA. Individuals with WRA had worse socioeconomic outcomes, worse asthma control, more quality-of-life impairment, and a higher prevalence of anxiety and depression than individuals with NWRA. Among individuals with WRA, those who had been removed from occupational exposure had a worse socioeconomic impact. ConclusionsConsequences on socioeconomic, asthma control, quality of life, and psychological status are worse for WRA individuals when compared with NWRA.
- Biomarkers related to silicosis and pulmonary function in individuals exposed to silica(2023) LOMBARDI, Elisa M. S.; MIZUTANI, Rafael F.; TERRA-FILHO, Mario; PAULA, Santos Ubiratan deBackgroundThe identification of markers that can facilitate the early diagnosis of silicosis has remained challenging. We evaluated the association of inflammatory markers with the presence of silicosis and lung function impairment in individuals exposed to silica. Methods Individuals exposed and not exposed to silica were assessed by occupational history, clinical findings, lung function, chest imaging findings, and inflammatory markers. Results Among 297 men evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), and macrophage inflammatory protein-4 (MIP-4) were associated with silicosis, and LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and fibrinogen were negatively associated with lung function. Conclusion Blood inflammatory markers are associated with silicosis and impaired lung function.
- Constrictive bronchiolitis secondary to exposure to flavoring agents: a little known occupational hazard(2023) ALMEIDA, Gustavo Correa de; MIZUTANI, Rafael Futoshi; TERRA-FILHO, Mario; SANTOS, Ubiratan de Paula
- Tobacco smoking associated with adverse childhood experiences in a Brazilian community university sample: A case-control study(2021) MAIA-SILVA, Keyla Medeiros; ZAMEL, Noe; SELBY, Peter; FONTES, Cor Jesus Fernandes; SANTOS, Ubiratan PaulaBackground: Adverse childhood experiences have been shown to have a great impact on adult health and social outcomes including tobacco smoking. Studies have shown this association but were mainly conducted in the USA. Objective: To evaluate the association between smoking, general characteristics, and adverse childhood experiences in a population of a Brazilian University. Participants and setting: Population formed by students and employees of a Brazilian University. Case-control observational study with a 1: 1 pairing by age, sex and education. The cases were defined as participants using nicotine-containing products, whether from burnt or unburned tobacco or electronic cigarettes, and the controls never users. Methods: We conducted the study using a Portuguese translation of the brief version of the family background questionnaire (8 adverse childhood experiences categories) in a group of 1056 participants with mean age of 31 years of a university community in Brazil. Smokers were compared to non-smokers on their adverse childhood experiences scores. Results: The prevalence of smoking in adulthood was significantly associated with the score of adverse childhood experiences. In addition, the level of tobacco dependence in adulthood also correlated with the score of adverse childhood. Conclusions: The association, including a possible dose-response relationship, in young adults between adverse childhood experiences and smoking was confirmed in a population of a Brazilian university. This further adds to our understanding of the determinants of adult tobacco use in a relatively more diverse cosmopolitan scenario.
- Silicosis in rutilated quartz miners in Brazil(2023) ROIO, Lavinia Clara Del; FREITAS, Jefferson Benedito Pires De; MIZUTANI, Rafael Futoshi; ALMEIDA, Gustavo Correa De; TERRA-FILHO, Mario; SANTOS, Ubiratan De Paula