MARTHA REGINA ARCON PEDROSO

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 3 Citação(ões) na Scopus
    COMPARING THE ENZYME REPLACEMENT THERAPY COST IN POST PANCREATECTOMY PATIENTS DUE TO PANCREATIC TUMOR AND CHRONIC PANCREATITIS
    (2016) FRAGOSO, Anna Victoria; PEDROSO, Martha Regina; HERMAN, Paulo; MONTAGNINI, André Luis
    ABSTRACT Background - Among late postoperative complications of pancreatectomy are the exocrine and endocrine pancreatic insufficiencies. The presence of exocrine pancreatic insufficiency imposes, as standard treatment, pancreatic enzyme replacement. Patients with chronic pancreatitis, with intractable pain or any complications with surgical treatment, are likely to present exocrine pancreatic insufficiency or have this condition worsened requiring adequate dose of pancreatic enzymes. Objective - The aim of this study is to compare the required dose of pancreatic enzyme and the enzyme replacement cost in post pancreatectomy patients with and without chronic pancreatitis. Methods - Observational cross-sectional study. In the first half of 2015 patients treated at the clinic of the Department of Gastrointestinal Surgery at Hospital das Clínicas, Universidade de São Paulo, Brazil, who underwent pancreatectomy for at least 6 months and in use of enzyme replacement therapy were included in this series. The study was approved by the Research Ethics Committee. The patients were divided into two groups according to the presence or absence of chronic pancreatitis prior to pancreatic surgery. For this study, P<0.05 was considered statistically significant. Results - The annual cost of the treatment was R$ 2150.5 ± 729.39; R$ 2118.18 ± 731.02 in patients without pancreatitis and R$ 2217.74 ± 736.30 in patients with pancreatitis. Conclusion - There was no statistically significant difference in the cost of treatment of enzyme replacement post pancreatectomy in patients with or without chronic pancreatitis prior to surgical indication.
  • bookPart
    Doenças Pancreáticas
    (2016) GUARITA, Dulce Reis; FELGA, Guilherme Eduardo Gonçalves; MARZINOTTO, Maira Andrade Nacimbem; TEIXEIRA, Ana Cristina de Sá; PEDROSO, Martha Regina Arcon; MOTT, Carlos de Barros
  • bookPart
    Doenças da Vesícula e das Vias Biliares
    (2016) PEDROSO, Martha Regina Arcon; TODA, Karla Sawada; GUEDES, Ana Luiza Vilar
  • article 16 Citação(ões) na Scopus
    Genetic Risk for Alcoholic Chronic Pancreatitis
    (2011) COSTA, Marianges Zadrozny Gouvea da; GUARITA, Dulce Reis; ONO-NITA, Suzane Kioko; PARANAGUA-VEZOZZO, Denise Cerqueira; FELGA, Guilherme Eduardo Goncalves; PEDROSO, Martha Regina Arcon; SOUZA, Marcelo Moreira Tavares de; NASSER, Paulo Dominguez; FERREIRA, Camila da Silva; CARRILHO, Flair Jose
    In recent years many studies have examined the genetic predisposition to pancreatic diseases. Pancreatic disease of an alcoholic etiology was determined to be a multi-factorial disease, where environmental factors interact with the genetic profile of the individual. In this review we discuss the main results from studies examining the frequency of genetic mutations in alcoholic chronic pancreatitis.