GLAUCE LEAO LIMA
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
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Agora exibindo 1 - 10 de 11
conferenceObject RELATIONSHIP BETWEEN SERUM LEVELS OF VITAMIN D, BMD AND LEAN MASS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(2013) COSTA, Aline; PETERS, Barbara; PAUPITZ, Juliane; LIMA, Glauce; PEREIRA, Rosa; MARTINI, Ligia- Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial(2016) LIMA, Glauce L.; PAUPITZ, Juliane; AIKAWA, Nadia E.; TAKAYAMA, Liliam; BONFA, Eloisa; PEREIRA, Rosa M. R.Objective. Vitamin D has an important immunomodulatory effect, but there are no trials that directly address the boosting of serum levels of 25-hydroxyvitamin D (25[ OH] D) in juvenile-onset systemic lupus erythematosus (SLE). The aim of this study was to evaluate the effect of vitamin D supplementation on disease activity and fatigue in juvenile-onset SLE. Methods. This study was a randomized, double-blind, placebo-controlled, 24-week trial. Forty juvenile-onset SLE patients were randomized (1: 1) to receive oral cholecalciferol 50,000 IU/week (juvenile-onset SLE-VitD) or placebo (juvenile-onset SLE-PL). Medications remained stable throughout the study. Serum levels of 25(OH) D were measured using radioimmunoassay. Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the European Consensus Lupus Activity Measurement (ECLAM). Fatigue was assessed using the Kids Fatigue Severity Scale (K-FSS). Results. At baseline, groups were similar regarding age, body mass index, organ involvement, glucocorticoid dose, use of immunosuppressive drugs, SLEDAI, ECLAM, K-FSS, and levels of 25(OH) D. After 24 weeks, the mean level of 25(OH) D was higher in the juvenile-onset SLE-VitD group than in the juvenile-onset SLE-PL group (P < 0.001). At the end of the intervention, a significant improvement in SLEDAI (P = 0.010) and in ECLAM (P = 0.006) was observed in the juvenile-onset SLE-VitD group compared to the juvenile-onset SLE-PL group. Regarding fatigue evaluation, a reduction of fatigue related to social life score was found in the juvenile-onset SLE-VitD group compared to the juvenile-onset SLE-PL group (P = 0.008). Cholecalciferol was well tolerated with no serious adverse events. Conclusion. This study suggests that cholecalciferol supplementation for 24 weeks is effective in decreasing disease activity and improving fatigue in juvenile-onset SLE patients.
conferenceObject BONE IMPAIRMENT ASSESSED BY HR-PQCT IN JUVENILE - ON SET SYSTEMIC LUPUS ERYTHEMATOSUS(2017) PEREIRA, R. M. R.; PAUPITZ, J. A.; LIMA, G. L.; ALVARENGA, J. C.; OLIVEIRA, R. M.; BONFA, E.conferenceObject Visceral Adiposity Assessed By DXA in Juvenile-Onset Systemic Lupus Erythematosus: A Correlation with Damage Index and Disease Duration(2016) PAUPITZ, Juliane; LIMA, Glauce; AIKAWA, Nadia E.; TAKAYAMA, Liliam; SEGURO, Luciana; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF VITAMIN D SUPPLEMENTATION IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: EFFECTS ON MICROARCHITECTURE USING HR-PQCT(2016) PAUPITZ, J. A.; LIMA, G. L.; AIKAWA, N. E.; ALVARENGA, J. C.; BONFA, E.; PEREIRA, R. M. R.conferenceObject A Randomized Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Improvement in Disease Activity and Fatigue Scores(2014) LIMA, Glauce; PAUPITZ, Juliane; TAKAYAMA, Liliam; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject A Randomised Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Effects on Microarchitecture Measured By HR-pQCT(2015) LIMA, Glauce; PAUPITZ, Juliane; AIKAWA, Nadia E.; ALVARENGA, Jackeline Couto; BONFY, Eloisa; PEREIRA, Rosa M. R.- Bone impairment assessed by HR-pQCT in juvenile-onset systemic lupus erythematosus(2016) PAUPITZ, J. A.; LIMA, G. L.; ALVARENGA, J. C.; OLIVEIRA, R. M.; BONFA, E.; PEREIRA, R. M. R.High-resolution peripheral quantitative computed tomography (HR-pQCT) analysis of female juvenile-onset systemic lupus erythematosus (JoSLE) patients revealed trabecular/cortical bone damage and reduced bone strength primarily at the distal radius compared to healthy controls. We demonstrated for the first time that JoSLE patients with vertebral fracture (VF) present trabecular impairment at the distal radius. This study investigated the volumetric bone mineral density (vBMD), microarchitecture, and biomechanical features at the distal radius and tibia using HR-pQCT and laboratory bone markers in JoSLE patients compared to controls to determine whether this method discriminates JoSLE patients with or without VF. We compared 56 female JoSLE patients to age- and Tanner-matched healthy controls. HR-pQCT was performed at the distal radius and tibia. Serum levels of the amino-terminal pro-peptide of type I collagen, the C-terminal telopeptide of type I collagen, intact parathormone, sclerostin, and 25-hydroxyvitamin D (25OHD) were evaluated. VFs were analyzed using VFA-dual-energy X-ray absorptiometry (DXA) (Genant's method). Reduced density and strength parameters and microarchitecture alterations of cortical and trabecular bones were observed in JoSLE patients compared to controls, primarily at the distal radius (p < 0.05). Patients with VF exhibited a significant decrease in trabecular bone parameters solely at the distal radius (Total.BMD, p = 0.034; Trabecular.BMD [Tb.BMD], p = 0.034; bone volume (BV)/trabecular volume (TV), p = 0.034; apparent modulus, p = 0.039) and higher scores for disease damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI), p = 0.002). Bone metabolism markers were similar in all groups. Logistic regression analysis of parameters that were significant in univariate analysis revealed that Tb.BMD (OR 0.98, 95 % CI 0.95-0.99, p = 0.039) and SLICC/ACR-DI (OR 7.37, 95 % CI 1.75-30.97, p = 0.006) were independent risk factors for VF. In conclusion, this study is the first demonstration of bone microstructure and strength deficits in JoSLE patients, particularly at the distal radius. Our results demonstrated that VF was associated with trabecular radius alteration and emphasized the potential detrimental effect of disease damage on this condition.
conferenceObject Trabecular Bone Microarchitecture Impairment in Juvenile Systemic Lupus Erythematous (JSLE) with Low BMD for Chronological Age(2013) PEREIRA, Rosa; PAUPITZ, Juliane; LIMA, Glauce; TAKAYAMA, Liliam; ALVARENGA, Jackeline; SEGURO, Luciana; BONFA, EloisaconferenceObject Trabecular Bone Impairment Assessed By HR-pQCT in Juvenile-Onset Systemic Lupus Erythematous with Vertebral Fractures(2014) PAUPITZ, Juliane; LIMA, Glauce; CAPARBO, Valeria; FULLER, Henrique; BONFA, Eloisa; PEREIRA, Rosa M. R.