TATIANA VILLAS BOAS GABBI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
19 resultados
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- Analysis of the reactivity of indirect immunofluorescence in patients with pemphigus foliaceus and pemphigus vulgaris using rat bladder epithelium as a substrate(2011) ORTOLAN, Damaris G.; SOUZA, Danielle P. G.; AOKI, Valeria; SANTI, Claudia G.; GABBI, Tatiana V. B.; ICHIMURA, Ligia M. F.; MARUTA, Celina W.OBJECTIVES: To evaluate the reactivity of indirect immunofluorescence using rat bladder epithelium as a substrate in patients with pemphigus foliaceus and pemphigus vulgaris from the Department of Dermatology, University of Sao Paulo Medical School, Brazil. METHODS: Thirty-two patients (8 male and 24 female) from the Department of Dermatology, University of Sao Paulo Medical School, were selected. Three had mucosal pemphigus vulgaris, 20 had mucocutaneous pemphigus vulgaris, and 9 had pemphigus foliaceus. Patients' sera were tested by indirect immunofluorescence performed on human foreskin and rat bladder epithelium and by ELISA assays utilizing baculovirus-expressed recombinant desmoglein 3 and desmoglein 1. RESULTS: No patients with mucosal pemphigus vulgaris, 5 of 20 patients with mucocutaneous pemphigus vulgaris (25%) and 4 of 9 patients with pemphigus foliaceus (44%) had positive indirect immunofluorescence using rat bladder epithelium as a substrate. CONCLUSION: Indirect immunofluorescence using rat bladder epithelium as a substrate is recommended whenever a diagnosis of paraneoplastic pemphigus is considered. The identification of a subset of pemphigus foliaceus and pemphigus vulgaris patients that recognizes desmoplakins by this laboratory tool is critical to avoid the misdiagnosis of paraneoplastic pemphigus.
- Evaluation of skin using infrared thermal imaging for dermatology and aesthetic applications(2022) VERGILIO, Mariane Massufero; GOMES, Guilherme; AIELLO, Laura Moretti; FONTANA, Monique; ALDRED, Alexandre; RIBEIRO, Joao Alberto de Souza; GABBI, Tatiana Villas Boas; LEONARDI, Gislaine RicciIntroduction The use of thermography in the medical field has been experiencing a renaissance due to advances in the infrared thermographic imaging technology, which improves thermographic equipment and promises cost saving and increased safety. Dermatology is one of the most promising fields of application among the medical areas with potential for the use of thermography. Objective To review the findings on this subject and to describe the use of such technique for dermatology and aesthetic applications. Methods A bibliographic survey was carried out, selecting relevant publications and guidelines, focused on monitoring medical diagnostic applications and benefits of thermography for dermatology, inflammatory skin diseases, and aesthetic applications. Results Inflammatory skin diseases lead to changes of the IRT image. A quantification of treatment effects and monitoring changes on skin can be possible by repeated measurements over time. Conclusion Infrared imaging is a noninvasive, powerful tool in the diagnosis and clinical management of skin conditions and monitoring of aesthetic procedures.
- Nail Apparatus Melanoma: Experience of 10 Years in a Single Institution(2019) LEE, Desiree Ji Re; ARBACHE, Samia Trigo; QUARESMA, Maria Victoria; NICO, Marcello Menta Simonsen; GABBI, Tatiana Villas BoasBackground: Nail apparatus melanoma (NAM) is rare. The higher mortality reported in the literature is most likely due to advanced disease associated with delayed diagnosis and treatment. Objective: All patients diagnosed with NAM were followed at a single reference center during a period of 10 years, with emphasis on dermatological and histological findings. Clinical outcomes were included. Methods: A retrospective review of medical records, photographs, and histopathological examination. Results: 73.7% of the patients were female and their mean age was 47 years. Caucasian and African-American patients had a similar incidence (47.4%). There was only 1 Asian patient in this study (5.3%). All patients presented with nail plate pigmentation. The mean prediagnosis duration was 33 months. A total of 63.2% patients had in situ melanoma and an average Breslow index of 2.18 mm in invasive cases. Fifteen patients underwent conservative surgery and 3 underwent phalanx amputation. All patients survived, and 4 have had more than a 5-year follow-up. Conclusion: In situ lesions showed longitudinal bands or total melanonychia with no nail dystrophy. Invasive cases presented with dystrophic lesions (longitudinal splitting of the nail). Conservative surgery provides a good option without worsening the prognosis. All dermatologists should be aware of early signs of NAM, since prognosis depends on early treatment.
- Squamous Cell Carcinoma Arising in Ungual Lichen Planus: Report and Review(2021) TAKATU, Caroline Maris; GABBI, Tatiana Villas Boas; NICO, Marcello Menta SimonsenBackground: Lichen planus (LP) can lead to severe scarring of the nail unit leading to anonychia. There are very few reports of squamous cell carcinoma (SCC) occurring in the lesions of ungual LP. Objective: The aim of this study was to revise the previously reported cases of SCC appearing in ungual LP and to present a new case. Methods: A PubMed search was performed with the terms ""nail lichen planus"" and ""squamous cell carcinoma."" Reported cases as well as a new case were depicted in a table. Results: Only 2 indexed articles reporting 3 cases were found. All patients suffered of long-lasting scarring ungual LP. Conclusions: The occurrence of SCC in nail LP is rare. LP is not ""premalignant"" per se, but SCC might rarely arise in LP scars.
- IgA pemphigus: Case series with emphasis on therapeutic response(2014) MORENO, Ana Carulina L.; SANTI, Claudia G.; GABBI, Tatiana V. B.; AOKI, Valeria; HASHIMOTO, Takashi; MARUTA, Celina W.
- Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit(2023) YENDO, Tatiana Mina; GABBI, Tatiana Villas Boas; NICO, Marcello Menta SimonsenIntroduction: Discoid lupus erythematosus can affect periungual tissues leading to onychodystrophy. Squamous cell carcinoma can occur in persistent scars of discoid lupus; this rare occurrence has not yet been reported on the nail unit. Case presentation: we report a case of squamous cell carcinoma occurring on the distal phalanx of the thumb in a patient with longstanding periungual discoid lupus on several fingernails. Discussion: Periungual discoid lupus erythematosus is rare. The scars caused by this disease can very rarely develop into squamous cell carcinoma. This is the first report of this occurrence at the periungual tissues.
bookPart Unhas(2019) GABBI, Tatiana Villas BoasbookPart Dermatoses das unhas(2022) GABBI, Tatiana Villas BoasconferenceObject Clinical features, etiologic findings, and therapeutic response in a series of 44 patients with recurrent erythema multiforme(2012) BARBOSA, Camila Anna; SANTI, Claudia Giuli; MARAGNO, Luciana; VALENTE, Neusa Sakay; GABBI, TatianaBackground: Erythema multiforme (EM) is a mucocutaneous disorder usually self-limited but potentially recurrent. Recurrent erythema multiforme (REM) etiology is not always evident and represents a therapeutic challenge. Aim: To report clinical, etiologic, and therapeutic aspects in 44 REM patients from São Paulo, Brazil. Methods: Datawereretrospectively collected from 44 REM cases from 2000 to 2011. Results: Out of 44 patients, 29 (66%) were female, mean age at disease onset was 35.2 and average of 4.6 outbreaks per year. Forty-three patients (98%) had cutaneous lesions. Mucous membranes involvement was present in 37 patients (84%), 37 patients with oral, 19 with genital and 4 with ocular involvement. Nineteen patients out of 44 (43%) referred herpetic lesions preceding EM outbreaks, 16 were submitted to Tzanck smear and six presented a positive result for herpes simplex cytophatic effect findings. Thirty-seven patients (84%) received prednisone, 39 (88%) prophylactic acyclovir, 8 (18%) valacyclovir, and 10 (23%) dapsone. Twenty-seven of 39 patients receiving continuous acyclovir treatment had partial or complete treatment response. Recalcitrant cases were submitted to alternative treatments: 3 out of 8 patients had partial response to valacyclovir and 5 out of 9 patients had either partial or complete response to dapsone. Three patients used either thalidomide or azathioprine without enough follow-up. Conclusion: REM maintains etiologic uncertainties that lead, at times, to suboptimal therapeutic responses. The relationship between HSV and REM cannot always be proved by laboratory examination, but prophylactic therapy with acyclovir should be considered.- Use of Smartphones in Telemedicine: Comparative Study Between Standard and Teledermatological Evaluation of High-Complex Care Hospital Inpatients(2016) OKITA, Aline Lissa; TINOCO, Luisa Juliatto Molina; PATATAS, Olivia Helena Gomes; GUERREIRO, Alinie; CRIADO, Paulo Ricardo; GABBI, Tatiana Villas Boas; FERREIRA, Paula Silva; FESTA NETO, CyroBackground: It is estimated that there are around 7 billion mobile phone subscriptions worldwide. Considering the availability and convenience, it appears to be a suitable device for store-and-forward (SF) consultations. Introduction: Although teledermatology has been suggested as an effective way of reducing costs and providing otherwise inaccessible expert evaluation, most studies have relied on high cost and high technological means. Materials and Methods: We conducted a study with inpatients that required dermatological evaluation in a high-complexity university hospital, accessing the correlation between traditional face-to-face evaluation and SF teledermatology, with data and pictures collected by medical students using smartphone cameras and then sent to consultants by e-mail. Results: For 2 months, we evaluated 100 patients and, as a result, the total agreement between both consultation modalities was 54%, the partial agreement was 27%, and the disagreement was 19%. Discussion: This study points out that SF teledermatology with the use of mobile phone is comparable to traditional face-to-face evaluation. Furthermore, most of the disagreements were probably related to the inexperience of the medical residents. Conclusion: Our study suggests that a smartphone-based teledermatology inpatient consultation model could be a reasonable option for hospitals lacking dermatological services. Also, it may be as or more effective than face-to-face consultations, if performed by a more experienced dermatologist. When feasible, photographing training should be performed.