FELIPE DALESSANDRO FERREIRA CORCHS
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
40 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 40
conferenceObject TRYPTOPHAN DEPLETION ENHANCES CARDIOVASCULAR RESPONSES TO STRESS IN RECOVERED PATIENTS WITH ANXIETY DISORDERS(2016) HOOD, S. D.; HINCE, D.; DAVIES, S. J. C.; ARGYROPOULOS, S. V.; CORCHS, F.; VELLIANITIS, A.; TANNENBAUM, J.; ROBINSON, H.; CHRISTMAS, D.; BELL, C. J.; POTOKAR, J.; NUTT, D. J.bookPart Aspectos psicológicos e comportamentais relevantes ao diagnóstico psiquiátrico(2014) SCHOUERI, Patrícia de Campos Lindenberg; ZOPPE, Eva Helena Costa Cardoso; SILVA, Maria Cecília Fernandes; CORCHS, Felipe; LOTUFO NETO, FranciscobookPart Transtorno de estresse agudo e transtorno de ajustamento(2021) ALVES, Marcos Carvalho; ARAúJO, Álvaro Cabral; CENACCHI, Paulo; ALBREGARD, Elizabeth F.; GRACINDO, Claudia Ballestero; SZTAMFATER, Silvia; SAKIYAMA, Bruno; LOTUFO NETO, Francisco; CORCHS, Felipe- Impact of post-traumatic stress disorder on oral health(2017) SOLIS, Ana Cristina de Oliveira; ARAUJO, Alvaro Cabral; CORCHS, Felipe; BERNIK, Marcio; DURAN, Erica Panzani; SILVA, Claudio; LOTUFO-NETO, FranciscoBackground: The stress experienced as an intense and traumatic event can increase the odds of orofacial pain, affect the biomechanics of masticatory system and compromise the periodontal health. This study was conducted to investigate the impact of post-traumatic stress disorder (PTSD) on oral health. Methods: A case-control study with a convenience sample was designed. Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing, and plaque were recorded at 6 sites per tooth. A visual analog scale (VAS) was used to evaluate the pain after probing. The Research Diagnostic Criteria for Temporomandibular Disorders Axis II (RDC/TMD Axis II) and Structured Clinical Interview (DSM-IV) were also applied. The final sample comprised 38 PTSD patients and 38 controls. Results: Patients with PTSD had a higher degree of chronic pain, more depression and nonspecific physical symptoms (including and excluding pain) compared with the control group (Fisher exact test p < 0.001, and Chi-squared test, p < 0.001,< 0.001,< 0.001, respectively). Patients with PTSD also had more pain after periodontal probing compared with controls (Mann-Whitney, p = 0.037). The prevalence of sites with CAL or PPD = 4, = 5, = 6 were not different between the groups. Age was associated with moderate periodontitis (multivariable logistic regression model, OR = 3.33, 95% CI = 1.03-10.75, p = 0.04). Limitation: The severity of PTSD precluded an ample sample size. Conclusions: Patients with PTSD presented a worse RDC/TMD Axis II profile, more pain after periodontal probing, and no difference related to periodontal clinical parameters. More studies are needed to confirm these findings.
- Evidence for serotonin function as a neurochemical difference between fear and anxiety disorders in humans?(2015) CORCHS, Felipe; NUTT, David J.; HINCE, Dana A.; DAVIES, Simon J. C.; BERNIK, Marcio; HOOD, Sean D.The relationships between serotonin and fear and anxiety disorders have been much studied yet many important questions remain, despite selective serotonin reuptake inhibitors having been the primary treatments for these disorders for some time. In order to explore this issue we performed a pooled analysis of six of our studies in remitted patients with a fear/anxiety disorder who were exposed to syndrome-specific aversive stimulation under acute tryptophan depletion. We based our analysis on the hypothesis that the inconsistencies observed in the studies could be predicted by Deakin and Graeff's theory about the dual role of serotonin in responses to threats, whereby serotonin is critical to prevent fear (panic) but not anxiety. In accordance with this view, our results give support to a dissociation of the disorders traditionally grouped under fear and anxiety-related disorders in terms of different roles of serotonin in modulation of responses to aversive stimulation. Implications for future studies and psychiatric nosology are discussed.
bookPart A psicoterapia pela perspectiva analítico-comportamental(2021) FIDALGO, Adriana; PERRONI, Carolina; CLIQUET, Guilherme Braga; JOAQUIM, Wilson Rafael Felício; BANACO, Roberto; CORCHS, Felipe- Early interventions for the prevention of PTSD in adults: a systematic literature review(2017) LINARES, Ila M. P.; CORCHS, Felipe D'Alessandro F.; CHAGAS, Marcos Hortes N.; ZUARDI, Antonio Waldo; MARTIN-SANTOS, Rocio; CRIPPA, Jose Alexandre S.Background: Secondary interventions are implemented within a short interval following the occurrence of traumatic events with the purpose of preventing the onset of PTSD. Objective: Analyze the results of studies that assessed post-trauma interventions in adults aimed at preventing the onset of PTSD or symptoms related to PTSD. Methods: We performed literature searches using the search expression [(Early intervention OR secondary prevention) AND (Post traumatic stress disorder OR PTSD)] for articles published until October 2016. Among the references found, 29 fulfilled the selection criteria established for the review. Data were divided and analyzed according to the type of intervention: pharmacological or psychological. Results: Psychological measures used in the studies lack homogeneity regarding the type of intervention and the assessment of intervention outcomes. Pharmacological interventions were less frequent and findings require replication, together with an expansion in the types of substances investigated. In general, many of the studies reviewed suggest that both pharmacological and psychological interventions are effective in the prevention of PTSD. Discussion: Future trials should be focused on determining the best interventions for the secondary prevention of PTSD. The combination of psychological and pharmacological interventions for post-trauma patients poses opportunities and challenges that remain unexplored.
bookPart Aspectos psicológicos e comportamentais relevantes oo diagnóstico psiquiátrico(2018) SCHOUERI, Patricia de Campos Lindenberg; ZOPPE, Eva Helena Costa Cardoso; SILVA, Maria Cecilia Fernandes; CORCHS, Felipe; LOTUFO NETO, FranciscobookPart Transtornos relacionados ao trauma e ao estresse(2014) CORCHS, Felipe; BOTTINO, Sara Mota Borges; CUNHA, Paulo Jannuzzi; SCIVOLETTO, Sandra- Targeting the reconsolidation of traumatic memories with a brief 2-session imaginal exposure intervention in post-traumatic stress disorder(2020) VERMES, Joana Singer; AYRES, Ricardo; GOES, Adara Saito; REAL, Natalia Del; ARAUJO, Alvaro Cabral; SCHILLER, Daniela; LOTUFO NETO, Francisco; CORCHS, FelipeBackground: Evidence suggests that extinction during memory reconsolidation diminishes the return of defensive responses. In order to translate these effects to the clinical setting, we tested whether retrieving a traumatic memory and delivering a brief two-sessions imaginal exposure intervention during its reconsolidation would produce stronger decreases in reactivity to these memories than standard imaginal exposure method. Methods: Participants with Post-Traumatic Stress Disorder (PTSD) had either their traumatic (n = 21) or a neutral (n = 21) memory retrieved 1 h before an imaginal exposure session for two consecutive days. One day before and one day after, participants were exposed to script-driven imagery of their traumatic event, during which skin conductance responses were measured and, immediately after, subjective responses were assessed by means of Visual Analogue Scales. Results: Traumatic retrieval improved the physiological, but not the subjective effects of imaginal exposure intervention on over-reactivity to traumatic memories. Conclusions: Our results suggest that delivering extinction-based treatments over the reconsolidation of traumatic memories may enhance its effects. These results suggest that this is a promising path toward the development of new therapeutic techniques.