CELSO RICARDO FERNANDES DE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina - Docente
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina - Líder
13 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 13
- Effect of an Exercise Program on Lymphocyte Proliferative Responses of COPD Patients(2018) FERNANDES, Juliana Ruiz; SILVA, Cibele Cristine Berto Marques da; SILVA, Aline Grandi da; PINTO, Regina Maria de Carvalho; DUARTE, Alberto Jose da Silva; CARVALHO, Celso Ricardo; BENARD, GilExercise training has been shown to reduce symptoms and exacerbations in COPD patients; however, the exercise effect on patients' immune response is poorly known. We thus verified if an exercise program (EP) impacted on proliferative T cell response of COPD patients. Fourteen non-O-2 dependent COPD patients on standard treatment were studied. EP consisted in 24 sessions of aerobic and muscular training. Peripheral blood mononuclear cells were stimulated with the mitogen phytohemagglutinin and antigens from Haemophilus influenzae and cytomegalovirus, and the lymphocyte proliferative response (LPR) was assessed through the expression of Ki67 before and after the EP. The Quality of life [COPD assessment test (CAT)], dyspnea [(modified Medical Research Council scale (mMRC)], and 6-min walk distance were also assessed. The EP program increased significantly the LPR of TCD4+ lymphocytes to phytohemagglutinin and cytomegalovirus and H. influenzae antigens, but with TCD8+ lymphocytes the increase was less marked. Consistent with this, a higher proportion of TCD8+ than TCD4+ cells did not express the costimulatory molecule CD28. The EP also resulted in improvement of the quality of life, dyspnea, and physical capacity. The improvement in TCD4+ cell function may represent an additional mechanism through which the EP results in less exacerbations and hospitalizations.
- Efeito agudo do salbutamol no sistema cardiovascular durante o exercício físico em pacientes com asma moderada ou grave: estudo aleatorizado, duplo-cego e cruzado(2018) MELO, Jaqueline Ribas de; FEITOZA, Maiane da Silva; CUCATO, Gabriel Grizzo; MEDEIROS, Wladimir Musetti; STELMACH, Rafael; CUKIER, Alberto; CARVALHO, Celso Ricardo Fernandes de; MENDES, Felipe Augusto RodriguesABSTRACT Salbutamol is a β2-agonist of short duration commonly used in patients with asthma to prevent symptoms during or after exercise. Hemodynamic changes at rest are well described. However, there is little data on the effects on heart rate (HR) and blood pressure (BP) during exercise and recovery phase in patients with moderate or severe asthma A randomized, double-blind, cross-over study was conducted, including 15 individuals with moderate and severe asthma, mean age 46.4±9.3 years. Patients underwent a maximal 2-day exercise test with 400 mcg salbutamol or 4 placebo puffs. Throughout the protocol, HR, BP, perceived exertion and peak of expiratory flow (PEF) were monitored. After the use of salbutamol, the PEF value increased by a mean of 28.0±47.7L/m, remaining increased at 5, 10 and 15 minutes of passive recovery compared to placebo (p<0.05). The HR, BP and effort perception variables were similar across interventions at all stages of the protocol (p>0.05). These results suggest that the use of salbutamol is safe and that HR does not need to be adjusted to prescribe exercise intensity following salbutamol administration in subjects with moderate or severe asthma.
- Aerobic fitness in asthmatic adolescents with fixed airway obstruction(2018) SOUSA, Andrey; SILVA, Ronaldo Aparecido; CABRAL, Anna Lucia; GRINDLER, Jose; FONSECA, Alfredo Jose; MARTINS, Milton Arruda; CARVALHO, Celso Rf
- Identification of asthma phenotypes using cluster analysis(2018) FREITAS, Patricia D.; XAVIER, Rafaella F.; SILVA, Simone T. C. da; CARVALHO-PINTO, Regina M.; STELMACH, Rafael; CUKIER, Alberto; MARTINS, Milton A.; CARVALHO, Celso R. F.
- Exercise improves physical activity and comorbidities in obese adults with asthma(2018) FREITAS, Patricia D.; SILVA, Aline G.; FERREIRA, Palmira G.; SILVA, Analuci Da; SALGE, Joao M.; CARVALHO-PINTO, Regina M.; CUKIER, Alberto; BRITO, Claudia M.; MANCINI, Marcio C.; CARVALHO, Celso R. F.
- Exercise Improves Physical Activity and Comorbidities in Obese Adults with Asthma(2018) FREITAS, Patricia Duarte; SILVA, Aline Grandi; FERREIRA, Palmira Gabriele; SILVA, Analuci Da; SALGE, Joao Marcos; CARVALHO-PINTO, Regina Maria; CUKIER, Alberto; BRITO, Claudia M.; MANCINI, Marcio C.; CARVALHO, Celso R. F.Introduction Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. Objective This study aimed to assess the effects of exercise on DLPA, asthma symptoms, and psychosocial comorbidities in obese adults with asthma. Methods Fifty-five grade II obese adults with asthma were randomly assigned to either a weight loss program + exercise program (WL + E group, n = 28) or a weight loss program + sham (WL + S group, n = 27). The WL + E group incorporated aerobic and resistance muscle training into the weight loss program (nutrition and psychological therapies), whereas the WL + S group performed breathing and stretching exercises. DLPA, asthma symptoms, sleep quality, and anxiety and depression symptoms were quantified before and after treatment. Results After 3 months, the WL + E group presented a significant increase in daily step counts (3068 2325 vs 729 +/- 1118 steps per day) and the number of asthma symptom-free days (14.5 +/- 9.6 vs 8.6 +/- 11.4 dmonth(-1)) compared with the WL + S group. The proportion of participants with improvements in depression symptoms (76.4% vs 16.6%) and a lower risk of developing obstructive sleep apnea (56.5% vs 16.3%) was greater in the WL + E group than that in the WL + S group (P < 0.05). Significant improvements in sleep efficiency (6.6% +/- 5.1% vs 1.3% +/- 4.7%) and latency (-3.7 +/- 5.9 vs 0.2 +/- 5.6 min) were also observed in the WL + E group. Conclusions Our results strongly suggest that exercise training plus a weight loss program improves DLPA, sleep efficiency, and depression and asthma symptoms in obese adults with asthma.
- Atopy in Elite Endurance Athletes(2018) TEIXEIRA, Renata N.; LEITE, Gerson dos Santos; BONINI, Matteo; GORJAO, Renata; AGONDI, Rosana C.; KOKRON, Cristina M.; CARVALHO, Celso R. F.Objective:To assess the frequency of atopy (specific IgE levels), to evaluate the allergic symptoms using the Allergy Questionnaire for Athletes (AQUA), and to determine whether atopy is associated with allergic symptoms in elite endurance athletes. Design: Cross-sectional study. Setting: Assessments were performed at Hospital das Clinicas-Sao Paulo University Medical School. Participants: Fifty-nine elite endurance athletes (triathletes and runners). Main Outcome Measures: Allergic symptoms were assessed by a validated self-report AQUA questionnaire and atopy by specific IgE level. Results: The frequency of atopy (specific IgE to at least one inhalant allergen) and allergic symptoms was 57.6% and 54.2%, respectively. In addition, no association was observed between atopy and allergic symptoms. Conclusions: A possible implication from our results is that atopy screening in elite athletes should be performed using AQUA questionnaire and measuring specific IgE simultaneously.
- Risk factors for asthma exacerbation in children and adolescents(2018) SOUSA, Andrey; CABRAL, Anna Lucia; MARTINS, Milton Arruda; CARVALHO, Celso Rf
- Association between muscle wasting and muscle strength in patients who developed severe sepsis and septic shock(2018) BORGES, Rodrigo; SORIANO, Francisco; CARVALHO, Celso