ANTONIO CARLOS ZANINI
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
BMF, ICB - Docente
BMF, ICB - Docente
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
bookPart Absorção, Vias de Administração e Formas Farmacêuticas(2018) OGA, Seizi; CARVALHO, Maria Fernanda; ZANINI, Antonio Carlos- Levothyroxine Absorption in Morbidly Obese Patients Before and After Roux-En-Y Gastric Bypass (RYGB) Surgery(2012) RUBIO, Ileana Gabriela Sanchez; GALRAO, Ana Luiza; SANTO, Marco Aurelio; ZANINI, Antonio Carlos; MEDEIROS-NETO, GeraldoRoux-en-Y gastric bypass (RYGB) modifies the anatomical structure of the upper intestine tract, reduces gastric acid secretion, and may impair LT4 absorption. The aim of this study was to evaluate the LT4 absorption in morbidly obese patients before and after RYGB. Thirty morbidly obese patients were divided in two groups: The NS group included 15 patients before RYGB surgery (BMI = 43.1 +/- 4 kg/m(2)), and the S group included 15 patients after surgery (BMI = 37.3 +/- 4 kg/m(2)). Two baseline samples were collected, and 600 mu g of oral LT4 tablets were administered. Blood samples were collected at 30, 60, 120, 180, 240, 300, and 1440 min. Serum-free T4 (FT4), total T4 (TT4), and TSH were measured at each time point. The increase in TT4, FT4, and TSH (Delta TT4, Delta FT4, and Delta TSH) was calculated, subtracting from the baseline mean value. The pharmacokinetics parameters regarding LT4 absorption, maximum Delta TT4, and area under the curve(AUC) of both Delta TT4 and Delta FT4 were significantly higher in the S group compared with the NS group (p < 0.05). It was observed, however, that there was a significant delay in the absorption of LT4 in the S group. Basal serum TSH and leptin levels were higher in the NS group (p = 0.016 and 0.026, respectively), whereas basal serum TT4, FT4, Delta TSH, and the AUC of Delta TSH were similar between groups. In this study, we have demonstrated that Roux-en-Y bypass surgery does not diminish LT4 absorption. A small but significant delayed absorption of LT4, however, was observed in patients after surgery.
bookPart Introdução à Farmacologia(2018) ZANINI, Antonio Carlos; OGA, Seizi; CARVALHO, Maria Fernanda; BATISTUZZO, José Antonio de OliveirabookPart Pesquisa Clínica de Medicamentos(2018) SOUZA, Raquel Chueiri; LOUSANA, Greyce; ZANINI, Antonio CarlosbookPart Sistema Hematológico(2018) ZANINI, Antonio Carlos; SPINA, Debora; ALMEIDA, Therezinha Verrastro debookPart Mediadores e Receptores(2018) SPINA, Debora; OGA, Seizi; ZANINI, Antonio Carlosbook Farmacologia aplicada [6.ed.](2018) ZANINI, Antonio CarlosbookPart Antivirais(2018) TEDESCO, Joel; SPINA, Debora; ZANINI, Antonio CarlosbookPart Distribuição, Biotransformação e Excreção de Fármacos(2018) OGA, Seizi; ZANINI, Antonio Carlos; FARSKY, Sandra Helena P.; MARCOURAKIS, TaniabookPart Gestão do Uso de Medicamentos(2018) VASCONCELLOS, Luis Augusto Morais de; DIAMENT, Mauricio; ZANINI, Antonio Carlos