VERONICA PORTO CARREIRO DE VASCONCELLOS COELHO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Regulatory/inflammatory cellular response discrimination in operational tolerance(2019) CARMONA, Priscila; MEDINA-ARMENTEROS, Yordanka; CABRAL, Amanda; MONTEIRO, Sandra Maria; FONSECA, Simone Goncalves; FARIA, Ana Caetano; LEMOS, Francine; SAITOVITCH, David; NORONHA, Irene L.; KALIL, Jorge; COELHO, VeronicaBackground. Antigen-specific cellular response is essential in immune tolerance. We tested whether antigen-specific cellular response is differentially modulated in operational tolerance (OT) in renal transplantation with respect to critical antigenic challenges in allotransplantation-donor antigens, pathogenic antigens and self-antigens. Methods. We analysed the profile of immunoregulatory (REG) and pro-inflammatory (INFLAMMA) cytokines for the antigen-specific response directed to these three antigen groups, by Luminex. Results. We showed that, in contrast to chronic rejection and healthy individuals, OT gives rise to an immunoregulatory deviation in the cellular response to donor human leucocyte antigen DR isotype peptides, while preserving the pro-inflammatory response to pathogenic peptides. Cellular autoreactivity to the N6 heat shock protein 60 (Hsp60) peptide also showed a REG profile in OT, increasing IL4, IL-5, IL-10 and IL-13. Conclusions. The REG shift of donor indirect alloreactivity in OT, with inhibition of interleukin (IL)-1B, IL-8, IL-12, IL-17, granulocyte colony-stimulating factor, Interferon-gamma and monocyte chemoattractant protein-1, indicates that this may be an important mechanism in OT. In addition, the differential REG profile of cellular response to the Hsp60 peptide in OT suggests that REG autoimmunity may also play a role in human transplantation tolerance. Despite cross-reactivity of antigen-specific T cell responses, a systemic functional antigen-specific discrimination takes place in OT.
- Rethinking the multiple roles of B cells in organ transplantation(2013) COELHO, Veronica; SAITOVITCH, David; KALIL, Jorge; SILVA, Hernandez MouraPurpose of review To discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and inflammatory (INFLAMMA) functions and to translate this knowledge for the development of novel immunomodulatory therapeutic strategies and to rethink the current ones. Recent findings Data from both experimental models and clinical trials point that B cells of various phenotypes have immunoregulatory activity and play an important role in controlling graft inflammation. Data on the state of operational tolerance, in kidney transplantation, suggest the relevance of preserving a healthy B-cell compartment - in numbers and in the Breg capacity to activate the CD40/STAT3 signalling pathway - for achieving and maintaining homeostasis. Moreover, autoantibodies also comprise transplant immunobiology and it seems that not all alloantibodies are deleterious. Summary The role of B cells, in organ transplantation, can no longer be taken as mere generators of plasma cells, which produce alloantibodies deleterious to the graft. B cells also seem to integrate a complex immunoregulatory network in organ transplantation, with Bregs of various phenotypes and possibly also antibodies. The functional discrimination of REG/INFLAMMA B-cell roles needs to be considered in the clinical setting.
conferenceObject Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile.(2019) DAVID-NETO, E.; FREITAS, G. Ramos de; FERNANDES, M.; AGENA, F.; LEMOS, F. Brambate Carvalhinho; PAULA, F. Jota de; COELHO, V.; GALANTE, N. ZocolerconferenceObject Everolimus/Low Tacrolimus Exposure versus Sodium Mycophenolate/ Standard Tacrolimus for the Elderly Kidney Transplant Recipient. A 4-y Follow -Up of the nEverOld Trial(2019) DAVID-NETO, E.; AGENA, F.; PAULA, F. J.; GALANTE, N. Z.; DAVID, D. S.; RAMOS, F.; TRIBONI, A. K.; ROMANO, P.; EBNER, P. A.; COELHO, V.; ALTONA, M.; FALCI, R.; PIOVESAN, A.; NAHAS, W. C.conferenceObject LOW DOSE ANTI-THYMOCYTE GLOBULIN INDUCTION THERAPY DIFFERENTIALLY DECREASES THE NUMBERS OF CIRCULATING LYMPHOCYTES AND REGULATORY T CELLS IN ELDERLY BUT NOT IN NON-ELDERLY KIDNEY TRANSPLANT RECIPIENT(2015) FREITAS, Geraldo Rubens Ramos; FERNANDES, Maria Da Luz; AGENA, Fabiana; TRIBONI, Ana Heloisa; RAMOS, Fernanda; LEMOS, Francine B. C.; NAHAS, Willian C.; DAVID-NETO, Elias; COELHO, Veronica; ZOCOLER, Galante NelsonconferenceObject Characterization of Peripheral Blood T and B Cells of Sensitized Kidney Transplant Recipients With Long Term Stable Graft Function(2015) GALANTE, N.; FERNANDES, M.; AGENA, F.; TRIBONI, A.; FREITAS, G.; AGUIRRE, A.; NAHAS, W.; COELHO, V.; DAVID-NETO, E.conferenceObject Senescence and Uremia Effects in Circulating T Cells Diverge in TREG Population and Cause T Cell Shift to a Memory Profile.(2017) FREITAS, G.; FERNANDES, M.; AGENA, F.; JABUUL, O.; COELHO, V.; LEMOS, F.; RAMOS, F.; TRIBONI, A.; DAVID-NETO, E.; GALANTE, N.