MARCELO RODRIGUES DOS SANTOS
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conferenceObject Discriminating sarcopenia in male patients with heart failure: the influence of body mass index(2018) SANTOS, M. R. Dos; FONSECA, G. W. P.; SOUZA, F. R.; CASTRO, V. M.; TAKAYAMA, L.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.conferenceObject Coronary inflammation by computed tomography pericoronary fat attenuation in young male anabolic androgenic steroid users(2022) SOUZA, F.; ROCHITTE, C. E.; SILVA, D. C.; GOMES, A. M. R.; SANTOS, M. R.; FONSECA, G. W. P.; BATTAGLIA, A. C. B. F.; CORREA, K. T. S.; YONAMINE, M.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.conferenceObject Impaired Baroreflex Sensitivity in Anabolic Steroid Users(2012) SANTOS, Marcelo Rodrigues dos; PORELLO, Rafael Armani; SAYEGH, Ana L. C.; HONG, Valeria; TOSCHI-DIAS, Edgar; BORTOLOTTO, Luiz A.; YONAMINE, Mauricio; NEGRAO, Carlos E.; ALVES, Maria-Janieire N. N.Purpose: Exacerbated sympathetic nerve activity and increased blood pressure have been documented in anabolic androgenic steroid users (AASU). We tested the hypothesis that arterial baroreflex sensitivity (BRS) and carotid distensibility would be reduced in AASU. Methods: Ten AASU and 10 age-paired anabolic androgenic steroid nonusers (AASNU) were studied. Both groups were involved in strength training (90% 1MR) and AASU were self-administered anabolic steroids for at least 2 years. The use of AAS was proved by urine. Heart rate (HR) was evaluated by EKG and blood pressure non-invasively on a beat to beat. BRS was analyzed by time domain through spontaneous fluctuations between systolic blood pressure (SBP) and HR. Carotid artery distensibility was measured by doppler (M-mode). Results: HR was higher in AASU compared to AASNU (69±3 vs. 59±3 bpm, P≤0.05). Systolic (123±4 vs. 118±2 mmHg, P=0.29), diastolic (72±2 vs. 67±2 mmHg, P=0.12) and mean blood pressure (90±3 vs. 85±2 mmHg, P=0.15) were not different between groups. BRS for increases (14.2±2 vs. 22.8±3 msec/mmHg, P=0.05) and decreases (13.3±1 vs. 19.2±2 msec/mmHg, P=0.04) were lower in AASU. Carotid distensibility was reduced in AASU (7±1 vs. 9±1 %, P≤0.05). Conclusion: Impaired BRS and reduced carotid distensibility may prematurely lead to increased cardiovascular risk in AASU.conferenceObject Dynamic cerebral autoregulation changes during sub-maximal handgrip maneuver(2013) NOGUEIRA, R. C.; BOR-SENG-SHU, E.; SANTOS, M. R.; NEGRAO, C. E.; TEIXEIRA, M. J.; PANERAI, R.conferenceObject Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure(2019) SANTOS, M. R. Dos; FONSECA, G. W. P.; SHERVENINAS, L.; SOUZA, F. R.; BATTAGLIA FILHO, A. C.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.; BARRETTO, A. C. P.conferenceObject Impact of exercise training and testosterone replacement on skeletal muscle atrophy and muscle sympathetic nerve activity in heart failure patients with hypogonadism(2014) SANTOS, M. R. Dos; SAYEGH, A. L.; BACURAU, A. V. N.; ARAP, M. A.; PEREIRA, R. M. R.; BRUM, P. C.; TAKAYAMA, L.; PEREIRA, A. C.; ALVES, M. J. N. N.conferenceObject Early findings in patients with noncompaction cardiomyopathy and normal ejection fraction: a cardiopulmonary exercise test, echocardiographic and biomarkers study(2019) AOKI, A. F.; SANTOS, M. R. Dos; ANDRETTA, C. R. L.; YEU, S. P.; MELO, M. D. Tavares De; JORDAO, C. P.; GUIMARAES, G. V.; STRUNZ, C. M. C.; BOCCHI, E. A.; SALEMI, V. M. C.conferenceObject Neurovascular Control and Spontaneous Baroreflex Sensitivity in Heart Failure Patients with Preserved Ejection Fraction(2014) SAYEGH, Ana Luiza C.; SANTOS, Marcelo R. dos; SOUZA, Francis R. de; SALEMI, Vera Maria C.; OLIVEIRA, Carlos Augusto P.; FONSECA, Felipe X.; RODRIGUES, Sara; TROMBETTA, Ivani C.; TOSCHI-DIAS, Edgar; NEGRAO, Carlos Eduardo; ALVES, Maria-Janieire N.; MADY, CharlesconferenceObject Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients(2012) ALVES, M. J. N. Nunes; SANTOS, M. R. Dos; NOBRE, T. S.; MARTINEZ, D. G.; BARRETTO, A. C. P.; BRUM, P. C.; RONDON, M. U. P. B.; MIDDLEKAUFF, H. R.; NEGRAO, C. E.Purpose: We recently described that systemic hypoxia provokes vasoconstriction in HF patients, Which might due to augmented sympathetic nerve activity to muscle (MSNA), in this study, we tested the hypothesis that either the exaggerated MSNA and/or blunted endothelial dysfunction mediate the blunted vasodilation during hypoxia in HF patients. Methods: Twenty seven HF patients and 23 age-matched healthy controls were studied. MSNA was assessed by microneurography and forearm blood flow (FBF) by venous occlusion plethysmography. Peripheral chemoreflex control was evaluated through the inhaling of a hypoxic gas mixture (10% O2 and 90% N2). Results: MSNA (P=0.001) were greater and basal FBF levels (P=0.003) were lower in HF patients versus controls. During hypoxia, MSNA responses were greater in HF patients (P=0.02), and forearm vasodilatation was blunted in HF compared to controls (P=0.002). In the presence of phentolamine, hypoxia significantly increased FBF responses in both groups, but the increase was lower in HF patients versus controls (P=0.003). Phentolamine + L-NMMA infusion during hypoxia did not change FBF responses in HF, but markedly blunted the vasodilatation in controls (P=0.96). FBF responses to hypoxia in the presence of vitamin C, an antioxidant that promotes NO availability, were unch anged when compared with saline infusion, and remained lower in HF patients versus controls. Conclusions: Muscle vasoconstriction in response to hypoxia in HF patients is due to exaggerated reflex sympathetic nerve activation and blunted endothelial function (NO activity). We were unable to identify a role for oxidative stress in these studies.conferenceObject Functional capacity in patients with restrictive syndromes: endomyocardial fibrosis versus constrictive pericarditis(2015) SAYEGH, A. L.; MELO, D. T. P.; SOUZA, F. R. De; SANTOS, M. R. Dos; DUTRA-MARQUES, A. C. B.; SALEMI, V. C.; NEGRAO, C. E.; MADY, C.; ALVES, M. J. N. N.; FERNANDES, F.