MARIA CLAUDIA COSTA IRIGOYEN

(Fonte: Lattes)
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    Improvement of the Adipokines Profile and Insulin Resistance in Metabolic Syndrome Patients Induced by Galantamine Activation of Cholinergic Pathway
    (2016) SANGALETI, Carine Teles; COSTA, Fernando Oliveira; MORAES, Tercio Lemos; IRIGOYEN, Maria Claudia; BORTOLOTTO, Luiz Aparecido Teles; LOPES, Heno Ferreira; PAVLOV, Valentin; TRACEY, Kevin; CONSOLIM-COLOMBO, Fernanda Marciano
  • conferenceObject
    COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
    (2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • conferenceObject
    Impact of sympathectomy upon myocardium
    (2019) PESSOA, F. Fernanda; JORDAO, M. R.; FONSECA, K. C. B.; ZANONI, F.; SALEMI, V. M. C.; RIBEIRO, O. N.; SOUZA, L. E.; FERNANDES, F.; IRIGOYEN, M. C.; MOREIRA, L. F. P.; MADY, C.; RAMIRES, F. J. A.
  • article 1 Citação(ões) na Scopus
    Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial
    (2021) SILVA, Leticia Maria Tedesco; CORTES, Antonio; ROSSI, Beatriz; BOLL, Liliana; WACLAWOSKY, Gustavo; EIBEL, Bruna; GONCALVES, Sandro Cadaval; IRIGOYEN, Maria Claudia; MARTINEZ, Denis
    Background: Sleep apnea and coronary artery disease are prevalent and relevant diseases. The mechanism by which sleep apnea leads to coronary artery disease remains unclear. Intermittent hypoxia, caused by sleep apnea, leads to inflammation and consequent endothelial dysfunction. Endothelial dysfunction precedes the development of atherosclerotic disease and the occurrence of cardiovascular events. Agents that potentially act to improve endothelial function can help prevent cardiovascular events. Patients using immunomodulators due to rheumatic diseases have a lower prevalence of cardiovascular diseases. However, the potential cardioprotective effect of these drugs in patients without autoimmune diseases is not clear. Hydroxychloroquine (HCQ) is an immunomodulator used to treat rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol and blood glucose levels and has antithrombotic effects. The drug is inexpensive and widely available. Adverse effects of HCQ are rare and occur more frequently with high doses. Objective: In this randomized clinical trial, the effect of HCQ treatment on endothelial function will be tested in seniors with sleep apnea. Methods: We will recruit participants over the age of 65 and with moderate-severe sleep apnea from an ongoing cohort. We chose to use this sample already evaluated for sleep apnea for reasons of convenience, but also because the elderly with sleep apnea are vulnerable to heart disease. Endothelial function will be assessed by examining flow-mediated dilation of the brachial artery, the gold standard method, considered an independent predictor of cardiovascular events in the general population and by peripheral arterial tonometry, the most recent and most easily obtained method. Hydroxychloroquine will be used at a dose of 400 mg/daily for 8 weeks. Discussion: Our study aims to obtain evidence, albeit preliminary, of the efficacy of hydroxychloroquine in improving endothelial function and reducing cardiovascular risk markers. If the improvement occurs, we plan to design a randomized multicenter clinical trial to confirm the findings.
  • conferenceObject
    Fluid overload as a biomarker of morbidity and mortality after cardiac surgery
    (2012) STEIN, A.; SOUZA, L. V. De; BELETTINI, C. R.; MENEGAZZO, W. R.; VIEGAS, J. R.; PEREIRA, E. M. Costa; EICK, R.; ARAUJO, L.; UNINOVE, F. Consolim-Colombo; IRIGOYEN, M.
  • article 4 Citação(ões) na Scopus
    Impact of Overweight in Mens with Family History of Hypertension: Early Heart Rate Variability and Oxidative Stress Disarrangements
    (2020) VIANA, Ariane; DIAS, Danielle da Silva; NASCIMENTO, Mario Cesar; SANTOS, Fernando dos; LANZA, Fernanda de Cordoba; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
    Aim. To evaluate cardiovascular, autonomic, and oxidative stress markers in eutrophic and overweight offspring of hypertensive parents comparing them to eutrophic and overweight offspring of normotensive parents.Methods. We conducted a cross-sectional study. We selected 71 male and sedentary subjects, divided into 4 groups: eutrophic group with a negative family history of hypertension (EH-,n=18) or positive family history of hypertension (EH+,n=17), overweight group with a negative family history of hypertension (OH-,n=19) or a positive family history of hypertension (OH+,n=17), and aged between 18 and 35 years.Results. Blood glucose was higher in the OH+ group when compared to other groups. Diastolic blood pressure was increased in OH- and OH+ groups when compared to eutrophic groups. Regarding the HRV, the LF abs was higher in OH- and OH+ groups when compared to the EH- group. LF/HF values were higher in EH+ and OH+ groups when compared to the EH- and OH- groups. As to oxidative stress and the metabolism of nitric oxide, we observed an increase in hydrogen peroxide and nitrite levels in the OH+ group, and in the NADPH oxidase in OH- and OH+ groups when compared to the other groups.Conclusion. Our findings demonstrate that the overweight group with a family history of hypertension presented all the dysfunctions observed in isolation from these risk factors. We observed an exacerbation of cardiac sympathetic modulation and early prooxidants increase, which may be associated with target organ damage and cardiovascular risk in this population.
  • article 57 Citação(ões) na Scopus
    Hypertension, Blood Pressure Variability, and Target Organ Lesion
    (2016) IRIGOYEN, Maria-Claudia; ANGELIS, Katia De; SANTOS, Fernando dos; DARTORA, Daniela R.; RODRIGUES, Bruno; CONSOLIM-COLOMBO, Fernanda Marciano
    Hypertensive patients have a higher risk of developing health complications, particularly cardiovascular (CV) events, than individuals with normal blood pressure (BP). Severity of complications depends on the magnitude of BP elevation and other CV risk factors associated with the target organ damage. Therefore, BP control and management of organ damage may contribute to reduce this risk. BP variability (BPV) has been considered a physiological marker of autonomic nervous system control and may be implicated in increased CV risk in hypertension. This review will present some evidence relating BPV and target organ damage in hypertension in clinical and experimental settings.
  • conferenceObject
    Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
    (2014) MALFITANO, C.; BARBOZA, C. A. B.; MOSTARDA, C. M.; PALMA, R. K. P.; CONSOLIM-COLOMBO, F. M. C. C.; BELLO-KLEIN, A. B. K.; IRIGOYEN, M. C. I.; ANGELIS, K. D. A. De
  • conferenceObject
    Effects of physical exercise and high fructose diet on cardiac autonomic control in rats
    (2012) FARAH, Daniela; NUNES, Jonas Pereira; BECHARA, Ana Carolina Carneiro; YOKOTA, Rodrigo; SARTORI, Michelle; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; FIORINO, Patricia; FARAH, Vera
  • article 20 Citação(ões) na Scopus
    Exercise training program based on minimum weekly frequencies: effects on blood pressure and physical fitness in elderly hypertensive patients
    (2012) MORAES, Wilson M. De; SOUZA, Pamella R. M.; PINHEIRO, Monica H. N. P.; IRIGOYEN, Maria C.; MEDEIROS, Alessandra; KOIKE, Marcia K.
    Background: Exercise training (ET) can reduce blood pressure (BP) and prevent functional disability. However, the effects of low volumes of training have been poorly studied, especially in elderly hypertensive patients. Objectives: To investigate the effects of a multi-component ET program (aerobic training, strength, flexibility, and balance) on BP, physical fitness, and functional ability of elderly hypertensive patients. Methods: Thirty-six elderly hypertensive patients with optimal clinical treatment underwent a multi-component ET program: two 60-minute sessions a week for 12 weeks at a Basic Health Unit. Results: Compared to pre-training values, systolic and diastolic BP were reduced by 3.6% and 1.2%, respectively (p < 0.001), body mass index was reduced by 1.1% (p < 0.001), and peripheral blood glucose was reduced by 2.5% (p= 0.002). There were improvements in all physical fitness domains: muscle strength (chair-stand test and elbow flexor test; p < 0.001), static balance test (unipedal stance test; p < 0.029), aerobic capacity (stationary gait test; p < 0.001), except for flexibility (sit and reach test). Moreover, there was a reduction in the time required to perform two functional ability tests: ""put on sock"" and ""sit down, stand up, and move around the house"" (p < 0.001). Conclusions: Lower volumes of ET improved BP, metabolic parameters, and physical fitness and reflected in the functional ability of elderly hypertensive patients. Trial Registration RBR-2xgjh3.