MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: KATIA BILHAR SCAPINI ×

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  • conferenceObject
    Inspiratory muscle training and aerobic training present similar effects on blood pressure and cardiovascular autonomic control in hypertensive patients
    (2015) FERREIRA, J.; SCAPINI, K. B.; SANTOS, F.; COELHO, O.; SOUZA, S. B.; LAGO, P. Dal; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.
  • article 9 Citação(ões) na Scopus
    Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice
    (2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SANTOS, Leandro Eziquiel dos; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katie B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Hello Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
    The present study aimed to compare the effects of moderate-intensity continuous and high-intensity interval exercise training (ET) on exercise tolerance, cardiac morphometry and function, hemodynamic, and cardiac autonomic modulation in myocardial infarcted mice. Wild-type mice (WT) were divided into four groups: sedentary WT (S); WT myocardium infarction sedentary (IS); WT myocardium infarction underwent to moderate-intensity continuous ET (MICT), and WT myocardium infarction underwent to high-intensity interval ET (MIIT). After 60 days of descending coronary artery ligation, moderate-intensity continuous ET consisted of running at 60% of maximum, while the high-intensity interval training consisted of eight sprints of 4 min at 80% of maximum and a 4-min recovery at 40% of maximum. Both exercises were performed 1 hr a day, 5 days a week, during 8 weeks. Results demonstrated that IS showed elevated exercise tolerance, as well as decreased hemodynamic and heart function, and autonomic control. On the other hand, both programs of ET were equally effective to increase all parameters, without further differences between the groups. In conclusion, the results of the present study showed that myocardial infarction leads to damage in both investigated strains and the two types of physical exercise attenuated the major impairments provoked by myocardial infarction in exercise tolerance, cardiac structure, cardiac function, hemodynamic and cardiac autonomic modulation.
  • article 7 Citação(ões) na Scopus
    Cardiovascular autonomic dysfunction in non-obese diabetic mice
    (2013) MORAES, Oscar A.; COLUCCI, Juliana A.; SOUZA, Leandro E.; SCAPINI, Katia B.; MORAES-SILVA, Ivana C.; MOSTARDA, Cristiano; ANGELIS, Katia De; CASARINI, Dulce E.; IRIGOYEN, Maria Claudia
    It is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). In the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. In conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction.
  • article 0 Citação(ões) na Scopus
    Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice (vol 13, pg 257, 2017)
    (2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SOUZA, Leandro Eziquiel de; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katia B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Helio Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
  • conferenceObject
    Loaded breathing exercise increases cardiovascular sympathetic modulation acutely in patients with essential hypertension
    (2015) FERREIRA, J.; SCAPINI, K. B.; SANTOS, F.; LAGO, P. Dal; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.
  • conferenceObject
    Erythropoietin promotes cardiac autonomic dysfunction and does not modify end diastolic pressure in a myocardial infarction model in rats
    (2015) ALBUQUERQUE, O.; SOUZA, L. E.; SCAPINI, K. B.; MOSTARDA, C.; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.
  • article 16 Citação(ões) na Scopus
    Cardiac autonomic dysfunction in chronic stroke women is attenuated after submaximal exercise test, as evaluated by linear and nonlinear analysis
    (2015) FRANCICA, Juliana Valente; BIGONGIARI, Aline; MOCHIZUKI, Luis; SCAPINI, Katia Bilhar; MORAES, Oscar Albuquerque; MOSTARDA, Cristiano; CAPERUTO, Erico Chagas; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; RODRIGUES, Bruno
    Background: We evaluated cardiac autonomic modulation in women with chronic ischemic stroke (at least 4 years post-stroke) at rest and in response to submaximal exercise test. Methods: Fourteen post-stroke women (S group) and 10 healthy women (C group) participated in this study. Autonomic modulation (using linear and nonlinear analysis), blood pressure and metabolic variables at rest were evaluated immediately after the exercise test and during the recovery period (20 min). All participants underwent submaximal exercise test on cycle ergometer with gas analysis. Results: At rest, the S group displayed higher lactate concentration, systolic (SBP) and diastolic blood pressure (DBP) values when compared to C group. Furthermore, the S group had lower heart rate variability (HRV) in time domain (SDNN: S = 30 +/- 5 vs. 40 +/- 8 ms; rMSSD: S = 14 +/- 2 vs. C = 34 +/- 3 ms), decreased high frequency band of pulse interval (S = 8.4 +/- 2 vs. 33.1 +/- 9 %) and 2V pattern of symbolic analysis (S = 17.3 +/- 1 vs. 30 +/- 3 %) (both indicators of cardiac vagal modulation) when compared to C group. Immediately after exercise, S group presented higher values of lactate, SBP, DBP and double product when compared to C group, as well as decreased heart rate recovery (HRR) measured at the first, second and third minutes. At recovery time, all HRV parameters in time and frequency domains improved in the S group; however, HF band remained lower when compared to C group. Conclusions: After the exercise test, women with chronic stroke presented reduced heart rate variability, reduced cardiac vagal modulation, as well as reduced HRR, while displayed an improvement of heart rate variability and cardiac vagal modulation when compared to their baseline. These results reinforce the importance of a physically active lifestyle for cardiovascular autonomic disorders observed in chronic stroke women.
  • article 17 Citação(ões) na Scopus
    Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats
    (2014) MOSTARDA, Cristiano T.; RODRIGUES, Bruno; MORAES, Oscar Albuquerque de; MORAES-SILVA, Ivana C.; ARRUDA, Paula Barros Olinto; CARDOSO, Ruymar; SCAPINI, Katia Bilhar; SANTOS, Fernando dos; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
    Aims: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into (n = 8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed. Results: Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabetic rats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68% +/- 1.3% vs. TD: 75% +/- 3.0%) and velocity of circumferential fiber shortening (SD: 0.32 +/- 0.02 vs. TD: 0.40 +/- 0.01 circ/seg.10(-4)). Trained diabetic rats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol. Conclusions: Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats.
  • conferenceObject
    CARDIOVASCULAR AND METABOLIC EFFECTS OF EXERCISE TRAINING IN HIGH-FAT DIET-FED OVARIECTOMIZED MICE: COMPARISON BETWEEN MODERATE INTENSITY CONTINUOUS VS. HIGH INTENSITY INTERVAL TRAINING
    (2018) NASCIMENTO-CARVALHO, Bruno; SANTOS, Adriano; SANTOS, Nicolas Costa; ASSIS, Abel Pereira; IRIGOYEN, Maria-Claudia Costa; ANGELIS, Katia De; CAPERUTO, Erico Chagas; SCAPINI, Katia Bilhar; SANCHES, Iris Callado
  • article 45 Citação(ões) na Scopus
    Combined training is the most effective training modality to improve aerobic capacity and blood pressure control in people requiring haemodialysis for end-stage renal disease: systematic review and network meta-analysis
    (2019) SCAPINI, Katia B.; BOHLKE, Maristela; MORAES, Oscar A.; RODRIGUES, Clarissa G.; INACIO, Jose F. S.; SBRUZZI, Graciele; LEGUISAMO, Camila P.; SANCHES, Iris C.; TOURINHO FILHO, Hugo; IRIGOYEN, Maria C.
    Questions: Do aerobic, resistance and combined exercise training improve aerobic capacity, arterial blood pressure and haemodialysis efficiency in people requiring haemodialysis for end-stage renal disease? Is one exercise training modality better than the others for improving these outcomes? Design: Systematic review with network meta-analysis of randomised trials. Participants: Adults requiring haemodialysis for end-stage renal disease. Intervention: Aerobic training, resistance training, combined training and control (no exercise or placebo). Outcome measures: Aerobic capacity, arterial blood pressure at rest, and haemodialysis efficiency. Results: Thirty-three trials involving 1254 participants were included. Direct meta-analyses were conducted first. Aerobic capacity improved significantly more with aerobic training (3.35 ml/kg/min, 95% CI 1.79 to 4.91) and combined training (5.00 ml/kg/min, 95% CI 3.50 to 6.50) than with control. Only combined training significantly reduced systolic (-9 mmHg, 95% CI - 13 to -4) and diastolic (-5 mmHg, 95% CI -6 to -3) blood pressure compared to control. Only aerobic training was superior to control for haemodialysis efficiency (Kt/V 0.11, 95% CI 0.02 to 0.20). However, when network meta-analysis was conducted, there were some important different findings. Both aerobic training and combined training again elicited greater improvements in aerobic capacity than control. For systolic blood pressure, combined training was superior to control. For diastolic blood pressure, combined training was superior to aerobic training and control. No modality was superior to control for haemodialysis efficiency. Combined training was ranked as the most effective treatment for aerobic capacity and arterial blood pressure. Conclusion: Combined training was the most effective modality to increase aerobic capacity and blood pressure control in people who require haemodialysis. This finding helps to fill the gap created by the lack of head-to-head comparisons of different modalities of exercise in people with end-stage renal disease. (C) 2018 Australian Physiotherapy Association.