MARIA CLAUDIA COSTA IRIGOYEN

(Fonte: Lattes)
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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  • article 6 Citação(ões) na Scopus
    Optimization of Vagal Stimulation Protocol Based on Spontaneous Breathing Rate
    (2018) SOUZA, Liliane Appratto De; FERREIRA, Janaina Barcellos; SCHEIN, Andressa Silveira de Oliveira; DARTORA, Daniela Ravizzoni; CASALI, Adenauer Girardi; SCASSOLA, Catharina M. Carvalho; TOBALDINI, Eleonora; MONTANO, Nicola; GUZZETTI, Stefano; PORTA, Alberto; IRIGOYEN, Maria Claudia; CASALI, Karina Rabello
    Controlled breathing maneuver is being widely applied for cardiovascular autonomic control evaluation and cardiac vagal activation through reduction of breathing rate (BR). However, this maneuver presented contradictory results depending on the protocol and the chosen BR. These variations may be related to the individual intrinsic profile baseline sympathetic tonus, as described before by others. In this study, we evaluated the effect of controlled breathing maneuver on cardiovascular autonomic control in 26 healthy subjects allocated into two protocols: (1) controlled breathing in three different rates (10, 15, and 20 breaths/min) and (2) controlled breathing in rates normalized by the individual spontaneous breathing rate (SBR) at 100, 80, 70, and 50%. Our results showed autonomic responses favorable to vagal modulation with the lower BR maneuvers. Nevertheless, while this activation was variable using the standard protocol, all participants of the normalized protocol demonstrated an increase of vagal modulation at 80% BR (HFnu 80 = 67.5% vs. 48.2%, p < 0.0001). These results suggest that controlled breathing protocols to induce vagal activation should consider the SBR, being limited to values moderately lower than the baseline.
  • article 0 Citação(ões) na Scopus
    Autonomic Nervous System, Inflammation, and Diabetes: Mechanisms and Possible Interventions
    (2012) IRIGOYEN, M. C.; CASARINI, Dulce Elena; MORRIS, Mariana; MONTANO, Nicola
  • article 47 Citação(ões) na Scopus
    Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
    (2011) JORGE, Luciana; RODRIGUES, Bruno; ROSA, Kaleizu Teodoro; MALFITANO, Christiane; LOUREIRO, Tatiana Carolina Alba; MEDEIROS, Alessandra; CURI, Rui; BRUM, Patricia Chakur; LACCHINI, Silvia; MONTANO, Nicola; ANGELIS, Katia De; IRIGOYEN, Maria-Claudia
    Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO2 max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO2 max). Left ventricular function was evaluated noninvasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.
  • article 5 Citação(ões) na Scopus
    Bicycling for transportation improves heart rate variability in young adults
    (2017) BUENO, Henrique M. P.; SARTORI, Michelle; MACEDO, Hidalina R.; MORAES-SILVA, Ivana C.; ALETTI, Federico; IRIGOYEN, Maria-Claudia; ANGELIS, Katia De
    BACKGROUND: Physical activity has been considered an effective method to treat and prevent cardiovascular and metabolic disease. An important mechanism benefited by exercise training is the cardiovascular autonomic control, often impaired in cardiometabolic disease. Cycling used as a daily means of transport can be considered an interesting alternative to regular physical exercise practice. Therefore, this study intent to compare metabolic, hemodynamic and cardiovascular autonomic profiles of young adult men who were used to cycle for transportation (CT) with those considered insufficiently actives (IA). METHODS: Body composition, blood pressure, glucose, total cholesterol and triglycerides were evaluated at rest. Heart rate variability was analyzed in time and frequency domains. RESULTS: No differences were observed for body composition, blood pressure, glycemia nor lipids between groups. CT group presented resting bradycardia. Heart rate variability was increased in cyclists, as well as the parameters of parasympathetic modulation. Sympathetic modulation was reduced in CT group when compared to IA group. Additionally, positive correlations were observed between resting heart rate and RMSSD and heart rate variability, while heart rate variability was correlated with sympathovagal balance. CONCLUSIONS: Our results demonstrated that bicycling regularly used as a means of transport is able to improve cardiovascular autonomic modulation, thus reducing the risk of cardiovascular disease.