MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    Inspiratory muscle training and aerobic training present similar effects on blood pressure and cardiovascular autonomic control in hypertensive patients
    (2015) FERREIRA, J.; SCAPINI, K. B.; SANTOS, F.; COELHO, O.; SOUZA, S. B.; LAGO, P. Dal; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.
  • conferenceObject
    Aerobic prevents sympathetic overactivity and left ventricle inflammation in rats
    (2015) BARBOZA, C. A.; CARROZZI, N. M.; OLIVEIRA, J. C. M. F.; SILVA, L. M.; MOSTARDA, C.; FERIANI, D. J.; ROCHA, L. Y.; ABSSAMRA, M.; IRIGOYEN, M. C.; RODRIGUES, B.
  • article 4 Citação(ões) na Scopus
    Increase in Vascular Injury of Sodium Overloaded Mice May be Related to Vascular Angiotensin Modulation
    (2015) LIMA, Cintia Taniguti; SILVA, Juliane Cristina de Souza; VIEGAS, Katia Aparecida da Silva; OLIVEIRA, Thais Cristina de Souza; LIMA, Rariane Silva de; SOUZA, Leandro Ezequiel de; ARAGAO, Danielle; CASARINI, Dulce Elena; IRIGOYEN, Maria Claudia; LACCHINI, Silvia
    This study aimed to analyzing the effect of chronic sodium overload upon carotid and femoral injury, and its relation to vascular angiotensin modulation. Male C57Bl6 mice were divided in: control (cont), receiving 1% NaCl solution for 2 weeks (salt-2) or 12 weeks (salt-12). Two-weeks before the end of the study, a 2mm catheter was implanted around the left femoral and carotid arteries to induce injury. Blood pressure (BP) and heart rate (HR) were measured at the end of the study by tail plethysmography. Arteries were collected and prepared for histological analysis to determine arterial thickening and perivascular collagen deposition. Angiotensin II and Ang(1-7) were quantified in fresh arteries using the HPLC method. There were no differences in body weight, BP and HR. Intima/media ratio had a similar increase in both injured arteries of cont and salt-2 mice, but a more pronounced increase was observed in salt-12 mice (31.1 +/- 6%). On the other hand, sodium overload modified perivascular collagen deposition, increasing thick fibers (cont: 0.5%; salt-2: 3.4%; salt-12: 0.6%) and decreasing thin fibers (cont: 7.4%; salt-2: 0.5%; salt-12: 6.8%) in non-injured arteries. Injured arteries presented similar collagen fiber distribution. Angiotensin quantification showed increased Ang(1-7) in salt treated mice (salt-2: +72%; salt-12: +45%) with a concomitant decrease in Ang II (salt-2: -54%; salt-12: -60%). Vascular injury increased significantly Ang(1-7) in salt-12 mice (+80%), maintaining Ang II reduction similar to that of a non-injured artery. The lack of changes in BP and HR suggests that the structural changes observed may be due to non-hemodynamic mechanisms such as local renin-angiotensin system. Collagen evaluation suggests that sodium overload induces time-related changes in vascular remodeling. The increase of artery injury with concomitant increase in Ang(1-7) in 12-week treated mice shows a direct association between the duration of salt treatment and the magnitude of vascular injury.
  • article 7 Citação(ões) na Scopus
    Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome
    (2015) CASTRO, E. F. S.; MOSTARDA, C. T.; RODRIGUES, B.; MORAES-SILVA, I. C.; FERIANI, D. J.; ANGELIS, K. De; IRIGOYEN, M. C.
    The present study aimed to study the effects of exercise training (ET) performed by rats on a 10-week high-fructose diet on metabolic, hemodynamic, and autonomic changes, as well as intraocular pressure (IOP). Male Wistar rats receiving fructose overload in drinking water (100 g/L) were concomitantly trained on a treadmill for 10 weeks (FT group) or kept sedentary (F group), and a control group (C) was kept in normal laboratory conditions. The metabolic evaluation comprised the Lee index, glycemia, and insulin tolerance test (KITT). Arterial pressure (AP) was measured directly, and systolic AP variability was performed to determine peripheral autonomic modulation. ET attenuated impaired metabolic parameters, AP, IOP, and ocular perfusion pressure (OPP) induced by fructose overload (FT vs F). The increase in peripheral sympathetic modulation in F rats, demonstrated by systolic AP variance and low frequency (LF) band (F: 37 +/- 2, 6.6 +/- 0.3 vs C: 26 +/- 3, 3.6 +/- 0.5 mmHg(2)), was prevented by ET (FT: 29 +/- 3, 3.4 +/- 0.7 mmHg(2)). Positive correlations were found between the LF band and right IOP (r=0.57, P=0.01) and left IOP (r=0.64, P=0.003). Negative correlations were noted between KITT values and right IOP (r=-0.55, P=0.01) and left IOP (r=-0.62, P=0.005). ET in rats effectively prevented metabolic abnormalities and AP and IOP increases promoted by a high-fructose diet. In addition, ocular benefits triggered by exercise training were associated with peripheral autonomic improvement.
  • article 0 Citação(ões) na Scopus
    Acetylsalicylic acid mitigates erythropoietin-associated blood pressure increase in nonuremic rats
    (2015) BOEHLKE, Maristela; GIESTEIRA, Rafael; CASTILHO, Claudia; PINHEIRO, Bartira; IRIGOYEN, Maria Claudia; FIGUEIREDO, Carlos Eduardo Poli de
    Background: Approximately 30% of the chronic kidney disease patients using recombinant human erythropoietin (rhuEPO) have an increase in blood pressure (BP). Its mechanism and whether it depends on renal function remain unclear. There is early evidence that acetylsalicylic acid (ASA) prevents the rhuEPO-induced increase in BP. This study aims to verify whether very high doses of rhuEPO can increase BP in nonuremic rats and whether the co-administration of ASA can prevent it. Methods: Forty male Wistar rats were divided into four groups: placebo/placebo; placebo/rhuEPO 200 UI/kg thrice weekly; placebo/ASA 50 mg/kg daily; rhuEPO 200 UI/kg thrice weekly/ASA 50 mg/kg daily. Hematocrit was measured before and after and systolic BP was measured weekly by tail-cuff technique. Direct measurement of the BP was obtained at the end. Results: The rhuEPO groups had higher final hematocrit (rhuEPO/placebo 56.7 +/- 7.6, rhuEPO/ASA 56.7 +/- 7.7; p < 0.001 versus placebo/placebo, 42.2 +/- 4.7 and ASA/placebo 41.2 +/- 4.2); and also increase in systolic BP (rhuEPO/placebo 135.1 +/- 15.0, p = 0.01 and rhuEPO/ASA 127.2 +/- 6.8, p = 0.02), whereas BP in rats from placebo/placebo (120.9 +/- 5.0, p = 0.18) and placebo/ASA (124.6 +/- 13.3, p = 0.12) groups remained unchanged. By direct measurement, the final BP was higher in rhuEPO/placebo (DBP 123.1 +/- 12.0; SBP 157.4 +/- 12.5; MBP 139.8 +/- 11.9) than placebo/placebo (DBP 105.1 +/- 11.5; SBP 141.0 +/- 12.6; MBP 122.1 +/- 12.1) and placebo/ASA groups (DBP 106.6 +/- 8.1; SBP 141.5 +/- 8.4, MBP 122.1 +/- 7.2) (p < 0.05 by post hoc Bonferroni test ANOVA). The rhuEPO/ASA group (PAD 115.1 +/- 11.4, PAS 147.4 +/- 9.1, MBP 130.1 +/- 10.3) was not different from other groups. Conclusions: The administration of very high doses of rhuEPO is associated with an increase in hematocrit and BP in nonuremic rats. The concomitant use of ASA mitigates the rhuEPO-associated BP increase.
  • article 51 Citação(ões) na Scopus
    Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations
    (2015) CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; BERNARDES, Nathalia; DIAS, Danielle da Silva; MALFITANO, Christiane; MORRIS, Mariana; LLESUY, Susana Francisca; IRIGOYEN, Maria-Claudia; ANGELIS, Katia De
    It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistar rats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 +/- 4 vs. C: 108 +/- 1 mmHg), heart rate (FHO: 403 +/- 12 vs. C: 352 +/- 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-alpha-FHO: 65.8 +/- 9.9 vs. C: 23.3 +/- 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 +/- 4 mmHg), heart rate (FHOT: 303 +/- 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-alpha (FHOT: 33.1 +/- 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.
  • conferenceObject
    CHRONIC NICOTINE EXPOSURE DOWNREGULATES RENAL KLOTHO EXPRESSION AND TRIGGERS DIFFERENT RENAL AND AUTONOMIC RESPONSES ACCORDING TO THE KLOTHO STATUS IN MICE
    (2015) COELHO, Fernanda O.; JORGE, Lecticia B.; BRAGANCA, Ana Carolina de; SANCHES, Talita R. C.; CANALE, Daniele; HELOU, Claudia M. B.; IRIGOYEN, Maria Claudia; KUROO, Makoto; ANDRADE, Lucia
  • conferenceObject
    Chronic treatment with orally active angiotensin-(1-7) formulation decrease oxidative damage and improve hemodynamic parameters in spontaneously hypertensive rats
    (2015) DARTORA, D. Ravizzoni; ROHR, P.; BERTAGNOLLI, M.; NASCIMENTO, A.; DIAS, D.; CASALLI, K. R.; ANGELIS, K. De; IRIGOYEN, M. C.; SANTOS, R. A.
  • conferenceObject
    Insulin Replacement Attenuates Autonomic Impairment but Did Not Prevent Early Diastolic Dysfunction in a Model of Type 1 Diabetes
    (2015) FREITAS, Sarah C.; DOURADO, Paulo M.; SANCHES, Iris C.; MACHI, Jacqueline F.; IRIGOYEN, Maria C.; ANGELIS, Katia De
  • article 10 Citação(ões) na Scopus
    Arg16Gly and Gln27Glu beta 2 adrenergic polymorphisms influence cardiac autonomic modulation and baroreflex sensitivity in healthy young Brazilians
    (2015) ATALA, Magda M.; GOULART, Alessandra; GUERRA, Grazia M.; MOSTARDA, Cristiano; RODRIGUES, Bruno; MELLO, Priscila R.; CASARINE, Dulce E.; IRIGOYEN, Maria-Claudia; PEREIRA, Alexandre C.; CONSOLIM-COLOMBO, Fernanda M.
    The association between functional beta(2) adrenergic receptor (beta(2)-AR) polymorphisms and cardiac autonomic modulation is still unclear. Thus, two common polymorphisms in the beta(2)-AR gene (Gln27Glu beta(2) and Arg16Gly beta(2)) were studied to determine whether they might affect tonic and reflex cardiac sympathetic activity in healthy young subjects. A total of 213 healthy young white subjects of both genders (53% female), aged 18-30 years (23.5 +/- 3.4 y), had their continuous blood pressure curves noninvasively recorded by Finometer at baseline, and other hemodynamic parameters, as cardiac autonomic modulation, baroreflex sensitivity, and allele, genotype, and diplotype frequencies calculated. Associations were made between Arg16Gly beta(2) and Gln27Glu beta(2) polymorphisms and between beta(2)-AR diplotypes and all variables. The heart rate was significantly lower (P<0.001) in the presence of homozygous Arg/Arg alleles (60.9 +/- 1.5 bpm) than in that of Arg/Gly heterozygotes (65.9 +/- 1.0 bpm) or Gly/Gly homozygotes (66.3 +/- 1.2 bpm). Homozygous carriers of Arg16 allele had an alpha index (19.2 +/- 1.3) significantly higher (P<0.001) than that of the subjects with the Gly allele Gly/Gly ( 14.5 +/- 0.7) or Arg/Gly (14.6 +/- 0.7). Furthermore, the recessive Glu27Glu and the heterozygous Gln27Glu genotypes had a higher percentage of low-frequency components (LF%) than the homozygous Gln27Gln (15.1% vs. 16.0% vs. 8.2%, P=0.03, respectively). In healthy young subjects, the presence of beta(2)-AR Arg16 allele in a recessive model was associated with higher baroreflex sensitivity, and increased parasympathetic modulation in studied individuals.