MARIA CLAUDIA COSTA IRIGOYEN
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
47 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 47
conferenceObject Improvement of the Adipokines Profile and Insulin Resistance in Metabolic Syndrome Patients Induced by Galantamine Activation of Cholinergic Pathway(2016) SANGALETI, Carine Teles; COSTA, Fernando Oliveira; MORAES, Tercio Lemos; IRIGOYEN, Maria Claudia; BORTOLOTTO, Luiz Aparecido Teles; LOPES, Heno Ferreira; PAVLOV, Valentin; TRACEY, Kevin; CONSOLIM-COLOMBO, Fernanda MarcianoconferenceObject COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME(2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia DeconferenceObject Effects of physical exercise and high fructose diet on cardiac autonomic control in rats(2012) FARAH, Daniela; NUNES, Jonas Pereira; BECHARA, Ana Carolina Carneiro; YOKOTA, Rodrigo; SARTORI, Michelle; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; FIORINO, Patricia; FARAH, VeraconferenceObject IMPACT OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE LEVELS ON BAROREFLEX IMPAIRMENT AND SYMPATHETIC HYPERACTIVITY AFTER A HIGH FRUCTOSE DIET(2017) MORAES-SILVA, Ivana C.; SOUZA, Leandro E. de; CASARINI, Dulce E.; IRIGOYEN, Maria-ClaudiaconferenceObject Combined exercise training improves cardiovascular and inflammatory parameters in an experimental model of metabolic syndrome and menopause(2014) CONTI, Filipe; BRITO, Janaina; DIAS, Danielle; BERNARDES, Nathalia; SANCHES, Iris; MALFITANO, Christiane; IRIGOYEN, Maria Claudia; ANGELIS, Katia DeconferenceObject The role of microRNA-208a in cardiac hypertrophy induced by aerobic physical training(2013) SOCI, Ursula Paula Reno; FERNANDES, Tiago; ROSA, Kaleizu T.; IRIGOYEN, Maria Claudia; PHILLIPS, M. Ian; OLIVEIRA, Edilamar Menezes deThe miRNA-208 regulates gene expression of slow myosin heavy chain(MHC)in heart. We investigated the role of miRNA-208 and its target Thyroid Hormone Receptor Associated Protein 1 (THRAP1) in aerobic training (AT) induced cardiac hypertrophy (CH). Female Wistar Rats(n=21)into 3 groups: sedentary (S), Trained 1(T1): swimming sessions of 60', 5 days/week (10 weeks). Trained 2(T2): similar to T1 until 8th week, on the 9th week the rats swan twice/day and on the 10th week 3 times/day. Were assessed: heart rate (HR), blood pressure (BP) by direct measurement, VO2max by ergoespirometry, soleus citrate synthase (CS) activity by spectrophotometer, ventricular function and CH by echocardiography (EGC), CH by LV/BW ratio (mg/g) and cardiomyocyte diameter (CD), gene expression of atrial natriuretic factor (ANF), skeletal α-actin, α-MHC and β-MHC and miR-208 by Real-time PCR and protein content of α and β-MHC and THRAP1 by Western Blott. AT decreased HR and increased VO2max (11%/T1 and 15%/T2) and CS (47%/T1 and 105%/T2). LV/BW ratio increased 13%/T1 and 28%/T2 and CD increased 20%/T1 and 30%/T2. Gene expression of skeletal α-actin decreased 53%/T2. The E/A ratio increased and isovolumetric relaxation time and myocardial performance index decreased. MiR-208 expression decreased 62%/T2 with a decrease of β-MHC and an increase of α-MHC gene expression(β/-71%,α/+37%) and protein content(β/–45 % α/+72%) in T2. THRAP1 protein increased 40%/T2 compared with S. APT induced physiological CH and improved diastolic function. MiR-208a and β-MHC expression decreased and THRAP-1 increased. The decrease of miR-208 was opposite to disease and can be a therapeutic strategy in pathological CH.conferenceObject Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State(2017) SANTOS, Fernando; MOREIRA, Edson Dias; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaconferenceObject Sympathetic and metabolic changes induced by hyperglycemia in myocardial infarction(2013) MALFITANO, Christiane; CARBONARO, Mariana; SOUZA JUNIOR, Alcione Lescano de; LOPES, Andressa B.; CASARINI, Dulce Elena; CURI, Rui; ANGELIS, Katia De; IRIGOYEN, Maria Claudia- Vitamin C Protects Against Doxorubicin-Induced Muscle Oxidative Stress(2022) NASCIMENTO FILHO, Antonio Viana Do; STOYELL-CONTI, Filipe F.; AKOLKAR, Gauri; MIRANDA, Victor Hugo M. De; SINGAL, Pawan; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; DIAS, Danielle Da Silva
conferenceObject Dynamic resistance training improves cardiovascular autonomic variability in male hypertensive rats(2017) ARAUJO, Amanda; DIAS, Danielle; BERNARDES, Nathalia; CONTI, Filipe; ALLIONI, Gabriela; IRIGOYEN, Maria Claudia; ANGELIS, Katia De