MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Biology ×

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Agora exibindo 1 - 10 de 52
  • conferenceObject
    Improvement of the Adipokines Profile and Insulin Resistance in Metabolic Syndrome Patients Induced by Galantamine Activation of Cholinergic Pathway
    (2016) SANGALETI, Carine Teles; COSTA, Fernando Oliveira; MORAES, Tercio Lemos; IRIGOYEN, Maria Claudia; BORTOLOTTO, Luiz Aparecido Teles; LOPES, Heno Ferreira; PAVLOV, Valentin; TRACEY, Kevin; CONSOLIM-COLOMBO, Fernanda Marciano
  • conferenceObject
    COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
    (2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • conferenceObject
    Effects of physical exercise and high fructose diet on cardiac autonomic control in rats
    (2012) FARAH, Daniela; NUNES, Jonas Pereira; BECHARA, Ana Carolina Carneiro; YOKOTA, Rodrigo; SARTORI, Michelle; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; FIORINO, Patricia; FARAH, Vera
  • conferenceObject
    IMPACT OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE LEVELS ON BAROREFLEX IMPAIRMENT AND SYMPATHETIC HYPERACTIVITY AFTER A HIGH FRUCTOSE DIET
    (2017) MORAES-SILVA, Ivana C.; SOUZA, Leandro E. de; CASARINI, Dulce E.; IRIGOYEN, Maria-Claudia
  • conferenceObject
    Combined exercise training improves cardiovascular and inflammatory parameters in an experimental model of metabolic syndrome and menopause
    (2014) CONTI, Filipe; BRITO, Janaina; DIAS, Danielle; BERNARDES, Nathalia; SANCHES, Iris; MALFITANO, Christiane; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 7 Citação(ões) na Scopus
    Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome
    (2015) CASTRO, E. F. S.; MOSTARDA, C. T.; RODRIGUES, B.; MORAES-SILVA, I. C.; FERIANI, D. J.; ANGELIS, K. De; IRIGOYEN, M. C.
    The present study aimed to study the effects of exercise training (ET) performed by rats on a 10-week high-fructose diet on metabolic, hemodynamic, and autonomic changes, as well as intraocular pressure (IOP). Male Wistar rats receiving fructose overload in drinking water (100 g/L) were concomitantly trained on a treadmill for 10 weeks (FT group) or kept sedentary (F group), and a control group (C) was kept in normal laboratory conditions. The metabolic evaluation comprised the Lee index, glycemia, and insulin tolerance test (KITT). Arterial pressure (AP) was measured directly, and systolic AP variability was performed to determine peripheral autonomic modulation. ET attenuated impaired metabolic parameters, AP, IOP, and ocular perfusion pressure (OPP) induced by fructose overload (FT vs F). The increase in peripheral sympathetic modulation in F rats, demonstrated by systolic AP variance and low frequency (LF) band (F: 37 +/- 2, 6.6 +/- 0.3 vs C: 26 +/- 3, 3.6 +/- 0.5 mmHg(2)), was prevented by ET (FT: 29 +/- 3, 3.4 +/- 0.7 mmHg(2)). Positive correlations were found between the LF band and right IOP (r=0.57, P=0.01) and left IOP (r=0.64, P=0.003). Negative correlations were noted between KITT values and right IOP (r=-0.55, P=0.01) and left IOP (r=-0.62, P=0.005). ET in rats effectively prevented metabolic abnormalities and AP and IOP increases promoted by a high-fructose diet. In addition, ocular benefits triggered by exercise training were associated with peripheral autonomic improvement.
  • conferenceObject
    The role of microRNA-208a in cardiac hypertrophy induced by aerobic physical training
    (2013) SOCI, Ursula Paula Reno; FERNANDES, Tiago; ROSA, Kaleizu T.; IRIGOYEN, Maria Claudia; PHILLIPS, M. Ian; OLIVEIRA, Edilamar Menezes de
    The miRNA-208 regulates gene expression of slow myosin heavy chain(MHC)in heart. We investigated the role of miRNA-208 and its target Thyroid Hormone Receptor Associated Protein 1 (THRAP1) in aerobic training (AT) induced cardiac hypertrophy (CH). Female Wistar Rats(n=21)into 3 groups: sedentary (S), Trained 1(T1): swimming sessions of 60', 5 days/week (10 weeks). Trained 2(T2): similar to T1 until 8th week, on the 9th week the rats swan twice/day and on the 10th week 3 times/day. Were assessed: heart rate (HR), blood pressure (BP) by direct measurement, VO2max by ergoespirometry, soleus citrate synthase (CS) activity by spectrophotometer, ventricular function and CH by echocardiography (EGC), CH by LV/BW ratio (mg/g) and cardiomyocyte diameter (CD), gene expression of atrial natriuretic factor (ANF), skeletal α-actin, α-MHC and β-MHC and miR-208 by Real-time PCR and protein content of α and β-MHC and THRAP1 by Western Blott. AT decreased HR and increased VO2max (11%/T1 and 15%/T2) and CS (47%/T1 and 105%/T2). LV/BW ratio increased 13%/T1 and 28%/T2 and CD increased 20%/T1 and 30%/T2. Gene expression of skeletal α-actin decreased 53%/T2. The E/A ratio increased and isovolumetric relaxation time and myocardial performance index decreased. MiR-208 expression decreased 62%/T2 with a decrease of β-MHC and an increase of α-MHC gene expression(β/-71%,α/+37%) and protein content(β/–45 % α/+72%) in T2. THRAP1 protein increased 40%/T2 compared with S. APT induced physiological CH and improved diastolic function. MiR-208a and β-MHC expression decreased and THRAP-1 increased. The decrease of miR-208 was opposite to disease and can be a therapeutic strategy in pathological CH.
  • conferenceObject
    Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State
    (2017) SANTOS, Fernando; MOREIRA, Edson Dias; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
  • article 8 Citação(ões) na Scopus
    Effects of different frequencies of transcutaneous electrical nerve stimulation on venous vascular reactivity
    (2014) FRANCO, O. S.; PAULITSCH, F. S.; PEREIRA, A. P. C.; TEIXEIRA, A. O.; MARTINS, C. N.; SILVA, A. M. V.; PLENTZ, R. D. M.; IRIGOYEN, M. C.; SIGNORI, L. U.
    Transcutaneous electrical nerve stimulation (TENS) is a type of therapy used primarily for analgesia, but also presents changes in the cardiovascular system responses; its effects are dependent upon application parameters. Alterations to the cardiovascular system suggest that TENS may modify venous vascular response. The objective of this study was to evaluate the effects of TENS at different frequencies (10 and 100 Hz) on venous vascular reactivity in healthy subjects. Twenty-nine healthy male volunteers were randomized into three groups: placebo (n = 10), low-frequency TENS (10 Hz, n = 9) and high-frequency TENS (100 Hz, n = 10). TENS was applied for 30 min in the nervous plexus trajectory from the superior member (from cervical to dorsal region of the fist) at low (10 Hz/200 mu s) and high frequency (100 Hz/200 mu s) with its intensity adjusted below the motor threshold and intensified every 5 min, intending to avoid accommodation. Venous vascular reactivity in response to phenylephrine, acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent) was assessed by the dorsal hand vein technique. The phenylephrine effective dose to achieve 70% vasoconstriction was reduced 53% (P<0.01) using low-frequency TENS (10 Hz), while in high-frequency stimulation (100 Hz), a 47% increased dose was needed (P<0.01). The endothelium-dependent (acetylcholine) and independent (sodium nitroprusside) responses were not modified by TENS, which modifies venous responsiveness, and increases the low-frequency sensitivity of alpha 1-adrenergic receptors and shows high-frequency opposite effects. These changes represent an important vascular effect caused by TENS with implications for hemodynamics, inflammation and analgesia.
  • conferenceObject
    Sympathetic and metabolic changes induced by hyperglycemia in myocardial infarction
    (2013) MALFITANO, Christiane; CARBONARO, Mariana; SOUZA JUNIOR, Alcione Lescano de; LOPES, Andressa B.; CASARINI, Dulce Elena; CURI, Rui; ANGELIS, Katia De; IRIGOYEN, Maria Claudia