MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Cell Biology ×

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Agora exibindo 1 - 10 de 55
  • conferenceObject
    Improvement of the Adipokines Profile and Insulin Resistance in Metabolic Syndrome Patients Induced by Galantamine Activation of Cholinergic Pathway
    (2016) SANGALETI, Carine Teles; COSTA, Fernando Oliveira; MORAES, Tercio Lemos; IRIGOYEN, Maria Claudia; BORTOLOTTO, Luiz Aparecido Teles; LOPES, Heno Ferreira; PAVLOV, Valentin; TRACEY, Kevin; CONSOLIM-COLOMBO, Fernanda Marciano
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    COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
    (2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 4 Citação(ões) na Scopus
    Impact of Overweight in Mens with Family History of Hypertension: Early Heart Rate Variability and Oxidative Stress Disarrangements
    (2020) VIANA, Ariane; DIAS, Danielle da Silva; NASCIMENTO, Mario Cesar; SANTOS, Fernando dos; LANZA, Fernanda de Cordoba; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
    Aim. To evaluate cardiovascular, autonomic, and oxidative stress markers in eutrophic and overweight offspring of hypertensive parents comparing them to eutrophic and overweight offspring of normotensive parents.Methods. We conducted a cross-sectional study. We selected 71 male and sedentary subjects, divided into 4 groups: eutrophic group with a negative family history of hypertension (EH-,n=18) or positive family history of hypertension (EH+,n=17), overweight group with a negative family history of hypertension (OH-,n=19) or a positive family history of hypertension (OH+,n=17), and aged between 18 and 35 years.Results. Blood glucose was higher in the OH+ group when compared to other groups. Diastolic blood pressure was increased in OH- and OH+ groups when compared to eutrophic groups. Regarding the HRV, the LF abs was higher in OH- and OH+ groups when compared to the EH- group. LF/HF values were higher in EH+ and OH+ groups when compared to the EH- and OH- groups. As to oxidative stress and the metabolism of nitric oxide, we observed an increase in hydrogen peroxide and nitrite levels in the OH+ group, and in the NADPH oxidase in OH- and OH+ groups when compared to the other groups.Conclusion. Our findings demonstrate that the overweight group with a family history of hypertension presented all the dysfunctions observed in isolation from these risk factors. We observed an exacerbation of cardiac sympathetic modulation and early prooxidants increase, which may be associated with target organ damage and cardiovascular risk in this population.
  • conferenceObject
    Effects of physical exercise and high fructose diet on cardiac autonomic control in rats
    (2012) FARAH, Daniela; NUNES, Jonas Pereira; BECHARA, Ana Carolina Carneiro; YOKOTA, Rodrigo; SARTORI, Michelle; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; FIORINO, Patricia; FARAH, Vera
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    IMPACT OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE LEVELS ON BAROREFLEX IMPAIRMENT AND SYMPATHETIC HYPERACTIVITY AFTER A HIGH FRUCTOSE DIET
    (2017) MORAES-SILVA, Ivana C.; SOUZA, Leandro E. de; CASARINI, Dulce E.; IRIGOYEN, Maria-Claudia
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    Combined exercise training improves cardiovascular and inflammatory parameters in an experimental model of metabolic syndrome and menopause
    (2014) CONTI, Filipe; BRITO, Janaina; DIAS, Danielle; BERNARDES, Nathalia; SANCHES, Iris; MALFITANO, Christiane; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
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    The role of microRNA-208a in cardiac hypertrophy induced by aerobic physical training
    (2013) SOCI, Ursula Paula Reno; FERNANDES, Tiago; ROSA, Kaleizu T.; IRIGOYEN, Maria Claudia; PHILLIPS, M. Ian; OLIVEIRA, Edilamar Menezes de
    The miRNA-208 regulates gene expression of slow myosin heavy chain(MHC)in heart. We investigated the role of miRNA-208 and its target Thyroid Hormone Receptor Associated Protein 1 (THRAP1) in aerobic training (AT) induced cardiac hypertrophy (CH). Female Wistar Rats(n=21)into 3 groups: sedentary (S), Trained 1(T1): swimming sessions of 60', 5 days/week (10 weeks). Trained 2(T2): similar to T1 until 8th week, on the 9th week the rats swan twice/day and on the 10th week 3 times/day. Were assessed: heart rate (HR), blood pressure (BP) by direct measurement, VO2max by ergoespirometry, soleus citrate synthase (CS) activity by spectrophotometer, ventricular function and CH by echocardiography (EGC), CH by LV/BW ratio (mg/g) and cardiomyocyte diameter (CD), gene expression of atrial natriuretic factor (ANF), skeletal α-actin, α-MHC and β-MHC and miR-208 by Real-time PCR and protein content of α and β-MHC and THRAP1 by Western Blott. AT decreased HR and increased VO2max (11%/T1 and 15%/T2) and CS (47%/T1 and 105%/T2). LV/BW ratio increased 13%/T1 and 28%/T2 and CD increased 20%/T1 and 30%/T2. Gene expression of skeletal α-actin decreased 53%/T2. The E/A ratio increased and isovolumetric relaxation time and myocardial performance index decreased. MiR-208 expression decreased 62%/T2 with a decrease of β-MHC and an increase of α-MHC gene expression(β/-71%,α/+37%) and protein content(β/–45 % α/+72%) in T2. THRAP1 protein increased 40%/T2 compared with S. APT induced physiological CH and improved diastolic function. MiR-208a and β-MHC expression decreased and THRAP-1 increased. The decrease of miR-208 was opposite to disease and can be a therapeutic strategy in pathological CH.
  • conferenceObject
    Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State
    (2017) SANTOS, Fernando; MOREIRA, Edson Dias; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
  • conferenceObject
    Sympathetic and metabolic changes induced by hyperglycemia in myocardial infarction
    (2013) MALFITANO, Christiane; CARBONARO, Mariana; SOUZA JUNIOR, Alcione Lescano de; LOPES, Andressa B.; CASARINI, Dulce Elena; CURI, Rui; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
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    Vitamin C Protects Against Doxorubicin-Induced Muscle Oxidative Stress
    (2022) NASCIMENTO FILHO, Antonio Viana Do; STOYELL-CONTI, Filipe F.; AKOLKAR, Gauri; MIRANDA, Victor Hugo M. De; SINGAL, Pawan; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; DIAS, Danielle Da Silva