BRUNO GUEDES BALDI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
49 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 49
conferenceObject Evaluation Of The Functional Impact Of The Use Of Doxycycline For Three Years In Patients With Lymphangioleiomyomatosis(2014) BALDI, B. G.; PIMENTA, S. P.; ARAUJO, M. S.; FREITAS, C. S. G.; KAIRALLA, R. A.; CARVALHO, C. R. R.- Diagnosis and treatment of interstitial lung disease related to systemic autoimmune myopathies: a narrative review(2023) SOUZA, F. H. C. de; ARAUJO, D. B. de; HOFF, L. S.; BALDI, B. G.; FARIA, M. S. M. S.; ROCHA JUNIOR, L. F. da; SILVA, L. R. S. Da; PINTO, Behrens; BEZERRA, M. C.; MIOSSI, R.; CORDEIRO, R. A.; SHINJO, S. K.Systemic autoimmune myopathies (SAMs) are rare diseases that lead to muscle inflammation and may be associated with a variety of systemic manifestations. Although there is great heterogeneity in the spectrum of extra-muscular involvement in SAMs, interstitial lung disease (ILD) is the most frequent lung manifestation. SAM-related ILD (SAM-ILD) presents significant variations according to geographic location and temporal trends and is associated with increased morbidity and mortality. Several myositis autoantibodies have been discovered over the last decades, including antibodies targeting aminoacyl-tRNA synthetase enzymes, which are associated with a variable risk of developing ILD and a myriad of other clinical features. In this review, the most relevant topics regarding clinical manifestations, risk factors, diagnostic tests, autoantibodies, treatment, and prognosis of SAM-ILD are highlighted. We searched PubMed for relevant articles published in English, Portuguese, or Spanish from January 2002 to September 2022. The most common SAM-ILD patterns are nonspecific interstitial pneumonia and organizing pneumonia. The combination of clinical, functional, laboratory, and tomographic features is usually sufficient for diagnostic confirmation, without the need for additional invasive methods. Glucocorticoids remain the first-line treatment for SAM-ILD, although other traditional immunosuppressants, such as azathioprine, mycophenolate, and cyclophosphamide have demonstrated some efficacy and, therefore, have an important role as steroid-sparing agents.
conferenceObject Mycobacterium Szulgai Infection In A Interstitial Lung Disease Patient(2017) GARCIA, M. F.; SCHUBSKY, J. V. K.; ARIMURA, F. E.; BALDI, B. G.; COSTA, A. N.; SALES, R. K. B.- Texture-based classification of lung disease patterns in chronic hypersensitivity pneumonitis and comparison to clinical outcomes(2021) PENNATI, F.; ALIBONI, L.; ANTONIAZZA, A.; BERETTA, D.; DIAS, O.; BALDI, B. G.; SAWAMURA, M.; CHATE, R. C.; CARVALHO, C. R. R. De; ALBUQUERQUE, A.; ALIVERTI, A.Computer-aided detection algorithms applied to CT lung imaging have the potential to objectively quantify pulmonary pathology. We aim to develop an automatic classification method based on textural features able to classify healthy and pathological patterns on CT lung images and to quantify the extent of each disease pattern in a group of patients with chronic hypersensitivity pneumonitis (cHP), in comparison to pulmonary function tests (PFTs). 27 cHP patients were scanned via high resolution CT (HRCT) at full-inspiration. Regions of interest (ROIs) were extracted and labeled as normal (NOR), ground glass opacity (GGO), reticulation (RET), consolidation (C), honeycombing (HB) and air trapping (AT). For each ROI, statistical, morphological and fractal parameters were computed. For automatic classification, we compared two classification methods (Bayesian and Support Vector Machine) and three ROI sizes. The classifier was therefore applied to the overall CT images and the extent of each class was calculated and compared to PFTs. Better classification accuracy was found for the Bayesian classifier and the 16x16 ROI size: 92.1 +/- 2.7%. The extent of GGO, HB and NOR significantly correlated with forced vital capacity (FVC) and the extent of NOR with carbon monoxide diffusing capacity (DLCO).
conferenceObject Association Of Sarcoidosis, Monoclonal Gammopathy Of Undetermined Significance And Cardiac Amyloidosis: A Case Report(2017) AMARAL, A. F.; OLIVEIRA, M. R.; ARIMURA, F. E.; NASCIMENTO, E. C. T.; BERNARDI, F. C.; FERNANDES, F.; CARVALHO, C. R. R.; KAIRALLA, R. A.; BALDI, B. G.conferenceObject A Rare Association Between Pulmonary Idiopathic Diffuse Neuroendocrine Hyperplasia and Organizing Pneumonia(2019) TAKIZAWA, D. B.; COLARES, P. F.; COSTA, F. M. da; BALDI, B. G.; KAIRALLA, R. A.; CARVALHO, C. R. R.conferenceObject Rapamycin As Treatment Of Lymphangioleiomyomatosis: Favorable Response In Different Clinical Manifestations(2014) FREITAS, C. S. G.; ARAUJO, M. S.; BALDI, B. G.; KAIRALLA, R. A.; CARVALHO, C. R. R.conferenceObject Constrictive Bronchiolitis Mimicking Pulmonary Lymphangioleiomyomatosis(2016) TOLEDO, A. P.; ENDLICH, B. N.; ARIMURA, F. E.; FREITAS, C. S.; NASCIMENTO, E. C. T.; BERNARDI, F. D. C.; DOLHNIKOFF, M.; KAIRALLA, R. A.; BALDI, B. G.; CARVALHO, C. R.conferenceObject Peribronchiolar Metaplasia Associated to Interstitial Lung Disease: A Case Report(2022) SANTOS, G. D.; BRIDI, G. D.; SAAVEDRA, N. L. M.; VASCONCELOS, A.; SILVA, N. F.; ALMEIDA, G. C.; NASCIMENTO, E. C. T.; ARIMURA, F. E.; AMARAL, A. F.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject High Prevalence of Possible Usual Interstitial Pneumonia Pattern in Chronic Hypersensitivity Pneumonitis at a Brazilian Reference Center(2018) AMARAL, A. F.; SCHUBSKY, J. V.; ARIMURA, F. E.; SAWAMURA, M. V.; BALDI, B. G.; CARVALHO, C. R.