BRUNO GUEDES BALDI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Atualização em pneumonia comunitária viral(2013) ROCHA NETO, Ozeas Galeno da; LEITE, Ricardo Ferreira; BALDI, Bruno GuedesViral pneumonia is a prevalent cause of respiratory infection in immunocompetent adults. It has varied presentation, from mild to severe respiratory failure, requiring mechanical ventilation. However, in Brazil, there have been few studies on the clinical presentation and diagnosis of this infection. Thus, the authors of the present article intend to review the main viral agents that cause community-acquired pneumonia and to discuss the currently available diagnostic and therapeutic methods.
conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro- Doxycycline use in patients with lymphangioleiomyomatosis: biomarkers and pulmonary function response(2013) PIMENTA, Suzana Pinheiro; BALDI, Bruno Guedes; KAIRALLA, Ronald Adib; CARVALHO, Carlos Roberto RibeiroObjective: To assess blockade of matrix metalloproteinase (MMP)-2 and MMP-9, as well as the variation in FEV1, in patients with lymphangioleiomyomatosis (LAM) treated with doxycycline (a known MMP inhibitor) for 12 months. Methods: An open-label, single-arm, interventional clinical trial in which LAM patients received doxycycline (100 mg/day) for 12 months. Patients underwent full pulmonary function testing, a six-minute walk test, and quality of life assessment, as well as blood and urine sampling for quantification of MMP-2, MMP-9, and VEGF-D levels at baseline, as well as at 6 and 12 months after the initiation of doxycycline. Results: Thirty-one LAM patients received doxycycline for 12 months. Although there was effective blockade of urinary MMP-9 and serum MMP-2 after treatment, there were no significant differences between pre-and post-doxycycline serum levels of MMP-9 and VEGF-D. On the basis of their response to doxycycline (as determined by the variation in FEV1), the patients were divided into two groups: the doxycydine-responder (doxy-R) group (n = 13); and the doxycycline-nonresponder (doxy-NR) group (n = 18). The patients with mild spirometric abnormalities responded better to doxycycline. The most common side effects were mild epigastric pain, nausea, and diarrhea. Conclusions: In patients with LAM, doxycydine treatment results in effective MMP blockade, as well as in improved lung function and quality of life in those with less severe disease. However, these benefits do not seem to be related to the MMP blockade, raising the hypothesis that there is a different mechanism of action. (Brazilian Registry of Clinical Trials - ReBEC; identification number RBR-6g8yz9 [http://www.ensaiosclinicos.gov.br]).
- A pilot study assessing the effect of bronchodilator on dynamic hyperinflation in LAM(2013) BALDI, Bruno Guedes; ALBUQUERQUE, Andre Luis Pereira de; PIMENTA, Suzana Pinheiro; SALGE, Joao Marcos; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroIntroduction: Positive responses to bronchodilators (BDs) on spirometry can be found in up to 30% of patients with lymphangioleiomyomatosis (LAM). However, no previous studies have investigated the impact of BDs on exercise outcomes, including dynamic hyperinflation (DH). Methods: A randomised, double-blind, placebo-controlled, crossover trial was conducted on 38 patients with LAM, comparing inhaled placebo versus salbutamol. Pulmonary function tests and a cycle endurance test at 75% of the maximal work capacity, with evaluation of DH by serial measurement of inspiratory capacity (IC), which was the primary endpoint, were performed after each intervention. Results: Although salbutamol produced a slight improvement in airway obstruction, compared with placebo, there was no significant variation in resting IC or air trapping. A total of 18% of the patients met the criteria for a positive response to BD. During submaximal exercise, BD did not reduce DH or dyspnoea nor did it improve exercise tolerance in the entire population. In addition, BD produced only slight improvement in FEV1 and air trapping in patients who had DH during incremental cardiopulmonary exercise testing, without the beneficial effects on exercise outcomes. Conclusions: Although salbutamol produced a slight improvement in airway obstruction, it did not lead to a reduction in DH or increase in exercise tolerance in patients with LAM. Clinical trial registration: Brazilian Registry of Clinical Trials (ReBEC); www.ensaiosclinicos.gov.br; registration number: RBR-49sk2j.
conferenceObject Features Of A Brazilian Cohort Of Patients With Lung-Dominant Connective Tissue Disease (ld-CTd)(2013) PEREIRA, D. A. S.; DIAS, O. M.; ALMEIDA, G. E.; ARAUJO, M. S.; KAWANO-DOURADO, L.; KAIRALLA, R. A.; CARVALHO, C. R. R.; BALDI, B. G.conferenceObject Pulmonary Involvement In Mixed Connective Tissue Disease: Slow Progression After 10 Years Of Follow-Up(2013) KAWANO-DOURADO, Leticia; DIAS, Olivia M.; KAY, Fernando U.; GRIPP, Thais E. H.; GOMES, Paula S.; FULLER, Ricardo; BALDI, Bruno G.; KAIRALLA, Ronaldo A.; CARVALHO, Carlos R. R.; CALEIRO, M. Teresa C.bookPart Exacerbação da Doença Pulmonar Obstrutiva Crônica(2013) SANTANA, Alfredo Nicodemos da Cruz; BALDI, Bruno Guedes; CUKIER, AlbertoconferenceObject Unusual multisystemic relapse of sarcoidosis after corticosteroids withdrawal(2013) ARAUJO, Mariana Sponholz; SILVA, Daniel Antunes; BALDI, Bruno Guedes; FREITAS, Carolina Salim Goncalves; PADOVESI, Celso Madeira; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroconferenceObject Survival And Decline In Lung Function In Patients With Lymphangioleiomyomatosis From A Brazilian Reference Center(2013) BALDI, B. G.; ARAUJO, M. S.; FREITAS, C. S. G.; PIMENTA, S. P.; DIAS, O. M.; PEREIRA, D. A. S.; KAIRALLA, R. A.; CARVALHO, C. R.- lnterpretacao da positividade de autoanticorpos na doenca pulmonar intersticial e colagenose pulmao dominante(2013) PEREIRA, Daniel Antunes Silva; KAWASSAKI, Alexandre de Melo; BALDI, Bruno GuedesThe initial evaluation of patients with interstitial lung disease (1LD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest the presence of a rheumatic disease, are routinely performed at various referral centers. When interstitial lung involvement is the condition that allows the definitive diagnosis of connective tissue disease and the classical criteria are met, there is little debate. However, there is still debate regarding the significance, relevance, specificity, and pathophysiological role of autoimmunity in patients with predominant pulmonary involvement and only mild or benign symptoms of connective tissue disease. The purpose of this article was to review the current knowledge of autoantibody positivity and to discuss its possible interpretations in patients with 1LD and without clear etiologic associations, as well as to enhance the understanding of the natural history of an allegedly new disease and to describe the possible prognostic implications. We also discuss the proposition of a new term to be used in the classification of 1LDs: lung-dominant connective tissue disease.