MARCELO TADEU CAIERO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
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- PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA(2018) ZUMARRAGA, Juan Pablo; BATISTA, Felipe Augusto Ribeiro; BAPTISTA, Andre Mathias; CAIERO, Marcelo Tadeu; MARTINO, Luis Pablo De La Rosa; CAMARGO, Olavo Pires DeObjective: Myxofibrosarcoma (MFS) is a common soft tissue sarcoma (STS) that affects the extremities in elderly patients. The objective was to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution. Methods: We retrospectively reviewed the records of 75 patients with MFS. We compared age, sex, tumor size and location, grade and stage of the disease. Median age was 49.7 years (range, 1 to 88 y). Location: upper extremity (25.4%), lower extremity (66.6%) and pelvis (8%). Patients had high-grade tumors in 46.7% of the reports. Margins were negative in 76% of the cases. Bivariate Cox regression analysis was used to determine associations between clinical and treatment factors with local recurrence (LR). Results: Median follow-up time was 30.7 months (range, 1.8 to 383.8 m). We found 26.7% of LR. Distant metastasis (DM) was reported in 27 (36%) patients. Lung was the most common site of DM, reported in 92.6% of patients. Overall survival (OS) with metastasis was 21.2 months (range, 4.8 to 114.8 m). Predictors of OS were grade, LR (hazard ratio [FIR] 5.13, 95% confidence interval, 2.15-12.24, P <0.001), and DM (HR 540.97, 95% confidence interval, 5.04-58112.03, P< 0.001). Conclusions: Tumor grade, LR, positive margins and DM were significant predictors of poor OS prognosis.
- Orthopedics: Musculoskeletal Tumors(2022) BAPTISTA, A. M.; REBOLLEDO, D. C. S.; JUNIOR, M. C. M. T.; CORREIA, L. F. M.; CAIERO, M. T.; TEIXEIRA, W. J.; NARAZAKI, D. K.; CAMARGO, A. F. de França; CAMARGO, O. P. deAmputation has historically been the first choice of treatment for patients with bone or soft tissue sarcomas of the extremities involving major blood vessels. However, recent advances in surgical technique have allowed limb-salvage surgery in a significant number of cases. Nowadays, most patients with malignant bone tumors can be treated with limb-salvage procedures whenever wide margins are possible. Surgical resection of bone and soft tissue tumors, with or without adjuvant radiation therapy, is effective in achieving local control, and limb-salvage procedures have been accepted because they achieve survival rates comparable to those of amputation allowing better quality of life. Along with other reconstructive techniques, vascular reconstruction might allow limb-sparing surgery and avoid amputation in patients with malignant tumors involving major vessels. Intraarterial embolization may as well serve as adjuvant therapy for major resection surgeries or therapeutic in some types of irresectable tumors. © Springer Nature Switzerland AG 2022.
- GCT: WHAT HAPPENED AFTER 10 YEARS OF CURETTAGE AND CEMENT? RETROSPECTIVE STUDY OF 46 CASES(2014) BAPTISTA, Andre Mathias; CAMARGO, Andre Ferrari de Franca; CAIERO, Marcelo Tadeu; REBOLLEDO, Daniel Cesar Seguel; CORREIA, Luiz Filipe Marques; CAMARGO, Olavo Pires deObjective: To compare the functional outcome of patients with and without arthrosis, and to determine whether the development of arthrosis is related to the distance of the tumor from the subchondral bone. Methods: Forty six patients treated for Giant-cell tumor (GCT) between 1975 and 1999 met inclusion criteria. GCT was diagnosed by percutaneous biopsy and confirmed after resection, in all cases. Campanacci's and Kellgren's classification, the distance of the cement to the articular surface and MSTS score were obtained throughout the sample. Results: The distance of the cement to the sub-chondral bone was associated with greater risk of developing arthrosis, but there was no difference in MSTS scores between patients with or without arthrosis. Conclusion: We found that the distance from the cement to the subchondral bone has a prognostic value regarding future arthrosis, but it does not impact on the functional outcome.
- PRIMARY LEIOMYOSARCOMA OF BONE: CLINICOPATHOLOGIC AND PROGNOSTIC FACTORS ANALYSIS IN A SINGLE INSTITUTION(2019) ZUMARRAGA, Juan Pablo; AROUCA, Matheus Manolo; BAPTISTA, Andre Mathias; CAIERO, Marcelo Tadeu; RUBIO, Diego Eduardo; CAMARGO, Olavo Pires deObjective: Primary leiomyosarcoma of bone (PLB) is a rare type of malignant bone tumor considered as a variant of the spindle cell sarcomas (SCS). The objective of this study was to analyze the clinicopathologic and the prognostic factors of patients with PLB treated at a single institution. Methods: We retrospectively reviewed the records of 22 patients with pathologically confirmed PLB. The data collected were: age, sex, tumor size and location, grade and stage of the disease and histopathologic features. Mean age was 45.5 years (range, 17 to 73 y). Location was: upper limb (27.3%), lower limb (68.2%) and pelvis (4.5%). Patients had high grade in 90.9% of the reports. Margins were negative in 77.3% of the cases. Histological reports describe spindly sarcomatous cells arranged in fascicles with increased vascular formation without osteoid or chondroid matrix production. On immunohistochemistry, smooth muscle actin and desmin where positive in all cases. Results: Mean follow-up time was 73.5 months (range, 5.3 to 331.1 m). We found 22.7% of local recurrence (LR). Distant metastasis (DM) was reported in 9 (40.9%) patients. Lung metastasis was the only DM affected site. Overall survival (OS) rate in 5 years was 59.1%. Predictors of OS were LR and DM. Conclusions: PLB is an extremely rare malignant bone tumor that has a higher rate of DM and similar OS prognosis compared with other bone sarcomas.
- SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA(2016) ZUMARRAGA, Juan Pablo; BAPTISTA, Andre Mathias; ROSA, Luis Pablo de La; CAIERO, Marcelo Tadeu; CAMARGO, Olavo Pires deObjective: To study the relationship between the pre and post chemotherapy (CT) serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) found in specimens after the pre surgical CT in patients with osteosarcoma. Methods: Series of cases with retrospective evaluation of patients diagnosed with osteosarcoma. Participants were divided into two groups according to serum values of both enzymes. The values of AP and LDH were obtained before and after preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens of each patient was also included. Results: One hundred and thirty seven medical records were included from 1990 to 2013. Both the AP as LDH decreased in the patients studied, being the higher in pre CT than post CT. The average LHD decrease was 795.12U/L and AP decrease was 437.40 U/L. The average TN was 34.10 %. There was no statistically significant correlation between the serums values and the percentage of tumoral necrosis. Conclusion: The serum levels values of AP and LDH are not good predictors for the chemotherapy-induced necrosis in patients with osteosarcoma.